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Few
mechanisms exist by which investigators in the early stages
of their careers can cost-effectively genotype single nucleotide
polymorphisms (SNPs) in candidate genes or regions in
small, moderate, or large-scale population-based association
studies. Furthermore, the current costs of in-house genotyping
and re-sequencing (e.g. capital equipment costs and assay
reagents), while becoming less expensive over time, are often
prohibitively expensive for junior investigators whose institutional
resources are limited. With financial support provided through
the National Heart, Lung, and Blood Institute's (NHLBI)
Program for Genomic Applications (PGA), SeattleSNPs is
offering genotyping services for SNPs in candidate genes to
investigators on a competitive application basis. Two genotyping
platforms will be available: SNPlex (Applied Biosystems) and
BeadArray (Illumina). Funding is available for approximately
2-3 moderate-sized studies (~1,500 individuals) genotyped
on the Illumina 384 SNP BeadArray platform and/or 1-2 smaller
studies (500 or fewer individuals) genotyped on the Applied
Biosystems SNPlex 48 SNP platform. In addition to genotyping
services, SeattleSNPs can provide consultation on SNP selection
(tagSNPs) and data management and analysis, if requested.
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Only applications describing research related to heart, lung,
blood, and/or sleep disorders will be considered. Preference will
be given to innovative junior investigators involved
in small or moderate-sized epidemiological studies. Newly
independent investigators, postdoctoral students, and senior
fellows are strongly encouraged to apply.
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To apply, please provide a cover letter containing the
principle investigator's contact information, an NIH biosketch for
all investigators involved in the project, and a narrative describing
the project using 10 single-spaced pages or less. We suggest
1 page for a project summary, 1-2 pages for project aims,
1-3 pages to justify the project, and five pages or less of
project methods. In the section used to justify the project,
please address the following questions:
- What makes this project innovative?
- Why do existing resources not permit the work to be done?
- How will this work facilitate future independent funding?
All application documents need to be compiled into
a single comprehensive document, which may be uploaded
via the application
page, or emailed to: ejt@u.washington.edu.
Applications are due June 1, 2007. Future application
deadlines will be posted on the SeattleSNPs website at http://pga.gs.washington.edu.
An external committee will review the applications and will
make recommendations to the SeattleSNPs PGA within three to
four months of the deadline.
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