SNPs in Assoication Studies
Why Association Studies
Confounding Effects
Association Study Designs
Epidemiology 101
Relative Risk (RR)
Odds Ratio (OR)
Odds Ratios and Relative Risk
Genetic Relative Risk
Risk Allele Example: 10% Population Frequency
Power analysis
Small sample: 50% Power
Maximizing Power
Large sample: 97.5% Power
Power to Detect SNP Risk: 200 Cases, 200 Controls
Power to Detect RR=2: N Cases, N Controls
Power Analysis Summary
SNP Selection for Association Studies
SNP Association
Linkage Disequilibrium
Hill's Alorithm
r2
D'
Perfect Linkage Disequilibrium
Complete Linkage Disequilibrium
LD in CSF3
Parameters for SNP Selection
Focus on Common Variants - Haplotype Patterns
Why Common Variants?
LD and Power
Power Model
Statistical Power and LD
Power and LD
LD Site Selection Algorithm
CSF3 Site Selection
Summary
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