The International Haplotype Map is developing a validated marker set using validated SNPs derived from dbSNP.
The ultimate goal of this project is to genotype up to 5,000,000 SNPs (~1 SNP/600 bp), in diverse populations
drawn from Europe, Asia, and the Americas. This data will then be used to develop a linkage disequilibrium based
map, divided into blocks, which define sets of correlated SNPs, to produce a common resource for genetic
In the last year, we have converted our SNP discovery panel to samples included in the
HapMap project. The SeattleSNPs project is now generating comprehensive SNP data for HapMap derived samples
from both the European and African populations. In tandem with this effort, we have also implemented a large-scale
genotyping effort, using Illumina BeadArray technology, to map highly informative tagSNPs from previously studied
SeattleSNPs candidate genes in the HapMap sample set (n = 60 unrelated, Yorubans; n = 60 unrelated, CEPH Europeans;
and n = 45 unrelated samples from Beijing, China, and n = 45 unrelated samples from Toyko, Japan). This genotyping
effort will serve to integrate our high-density SNP map (~1/300 bp) with the SNP dataset currently being produced
by the International HapMap Project. In addition, we have also performed genotyping on non-HapMap samples from Hispanic
(n = 50) and African-American (n = 62) populations, to represent other major groups in the United States.