LOCUS PTGES 18549 bp DNA linear PRI 14-JUN-2006 DEFINITION Homo sapiens PTGES prostaglandin E synthase (PTGES) gene, complete cds. ACCESSION PTGES VERSION tmp KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 18549) AUTHORS Rieder,M.J., Johanson,E.J., da Ponte,S.H., Hastings,N.C., Ahearn,M.O., Bertucci,C.B., Wong,M.W., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (14-JUN-2006) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI HL66682 Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu). FEATURES Location/Qualifiers source 1..18549 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" repeat_region 61..339 /rpt_family="Alu" /rpt_type=dispersed variation 122 /frequency="0.01" /replace="T" variation 234 /frequency="0.01" /replace="C" variation 263 /frequency="0.03" /replace="C" repeat_region 344..401 /rpt_family="ERV1" /rpt_type=dispersed repeat_region 402..698 /rpt_family="Alu" /rpt_type=dispersed variation 457 /frequency="0.02" /replace="C" variation 463 /frequency="0.03" /replace="G" variation 476 /frequency="0.01" /replace="T" variation 542 /frequency="0.02" /replace="T" variation 603 /frequency="0.15" /replace="C" repeat_region 699..829 /rpt_family="ERV1" /rpt_type=dispersed repeat_region 830..1356 /rpt_family="MaLR" /rpt_type=dispersed variation 861 /frequency="0.01" /replace="A" variation 1193 /frequency="0.39" /replace="A" variation 1194 /frequency="0.39" /replace="T" variation 1282 /frequency="0.01" /replace="C" variation 1353 /frequency="0.09" /replace="T" repeat_region 1357..1380 /rpt_family="ERV1" /rpt_type=dispersed variation 1418 /frequency="0.40" /replace="C" variation 1488 /frequency="0.01" /replace="T" variation 1561 /frequency="0.14" /replace="A" gene 1804..16550 /gene="PTGES" mRNA join(1804..1982,6132..6214,15023..16550) /gene="PTGES" /product="PTGES" CDS join(1857..1982,6132..6214,15023..15272) /gene="PTGES" /codon_start=1 /product="PTGES prostaglandin E synthase" /translation="MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAF ANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMH FLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL" variation 1876 /gene="PTGES" /frequency="0.02" /replace="A" variation 1901 /gene="PTGES" /frequency="0.10" /replace="T" variation 2067 /gene="PTGES" /frequency="0.43" /replace="G" variation 2161 /gene="PTGES" /frequency="0.07" /replace="T" variation 2199 /gene="PTGES" /frequency="0.01" /replace="A" variation 2259 /gene="PTGES" /frequency="0.26" /replace="A" variation 2315 /gene="PTGES" /frequency="0.02" /replace="A" variation 2621 /gene="PTGES" /frequency="0.02" /replace="A" variation 2944 /gene="PTGES" /frequency="0.01" /replace="T" variation 3008 /gene="PTGES" /frequency="0.16" /replace="A" repeat_region 3017..3128 /rpt_family="MIR" /rpt_type=dispersed misc_feature 3104..3261 /gene="PTGES" /note="Region not scanned for variation" repeat_region 3186..3472 /rpt_family="Alu" /rpt_type=dispersed variation 3318 /gene="PTGES" /frequency="0.41" /replace="G" variation 3349 /gene="PTGES" /frequency="0.14" /replace="G" variation 3372 /gene="PTGES" /frequency="0.01" /replace="T" variation 3397 /gene="PTGES" /frequency="0.18" /replace="T" repeat_region 3509..3824 /rpt_family="Alu" /rpt_type=dispersed variation 3526 /gene="PTGES" /frequency="0.09" /replace="G" variation 3585 /gene="PTGES" /frequency="0.06" /replace="G" variation 3664 /gene="PTGES" /frequency="0.10" /replace="C" repeat_region 4036..4120 /rpt_family="MIR" /rpt_type=dispersed variation 4122 /gene="PTGES" /frequency="0.01" /replace="T" variation 4268 /gene="PTGES" /frequency="0.08" /replace="C" variation 4297 /gene="PTGES" /frequency="0.08" /replace="C" variation 4346 /gene="PTGES" /frequency="0.03" /replace="C" variation 4373 /gene="PTGES" /frequency="0.08" /replace="T" variation 4690 /gene="PTGES" /frequency="0.04" /replace="C" repeat_region 4781..4823 /rpt_family="L2" /rpt_type=dispersed variation 4842 /gene="PTGES" /frequency="0.05" /replace="G" variation 4862 /gene="PTGES" /frequency="0.02" /replace="A" repeat_region 4940..5197 /rpt_family="L2" /rpt_type=dispersed repeat_region 5199..5503 /rpt_family="Alu" /rpt_type=dispersed repeat_region 5550..5759 /rpt_family="Alu" /rpt_type=dispersed repeat_region 5762..5983 /rpt_family="L2" /rpt_type=dispersed variation 6188 /gene="PTGES" /frequency="0.09" /replace="T" variation 6236 /gene="PTGES" /frequency="0.09" /replace="T" variation 6437 /gene="PTGES" /frequency="0.01" /replace="A" variation 6500 /gene="PTGES" /frequency="0.01" /replace="T" misc_feature 6667..6832 /gene="PTGES" /note="Region not scanned for variation" repeat_region 6831..7141 /rpt_family="Alu" /rpt_type=dispersed variation 6890 /gene="PTGES" /frequency="0.02" /replace="A" variation 7021 /gene="PTGES" /frequency="0.04" /replace="C" variation 7088 /gene="PTGES" /frequency="0.02" /replace="T" variation 7261 /gene="PTGES" /frequency="0.01" /replace="A" repeat_region 7269..7388 /rpt_family="L1" /rpt_type=dispersed variation 7395 /gene="PTGES" /frequency="0.06" /replace="G" variation 7448 /gene="PTGES" /frequency="0.01" /replace="T" variation 7463 /gene="PTGES" /frequency="0.01" /replace="C" variation 7640 /gene="PTGES" /frequency="0.03" /replace="C" repeat_region 7676..7966 /rpt_family="Alu" /rpt_type=dispersed variation 7745..7757 /gene="PTGES" /frequency="0.86" /replace="" variation 7775 /gene="PTGES" /frequency="0.32" /replace="A" variation 7986 /gene="PTGES" /frequency="0.01" /replace="A" variation 8189 /gene="PTGES" /frequency="0.08" /replace="C" variation 8299 /gene="PTGES" /frequency="0.86" /replace="" repeat_region 8436..8499 /rpt_family="L2" /rpt_type=dispersed misc_feature 8705..8821 /gene="PTGES" /note="Region not scanned for variation" repeat_region 8832..9135 /rpt_family="Alu" /rpt_type=dispersed variation 9090 /gene="PTGES" /frequency="0.13" /replace="C" variation 9252 /gene="PTGES" /frequency="0.23" /replace="G" variation 9260 /gene="PTGES" /frequency="0.01" /replace="A" variation 9300 /gene="PTGES" /frequency="0.01" /replace="T" repeat_region 9798..9950 /rpt_family="MIR" /rpt_type=dispersed misc_feature 9828..10289 /gene="PTGES" /note="Region not scanned for variation" repeat_region 9992..10289 /rpt_family="Alu" /rpt_type=dispersed repeat_region 10290..10577 /rpt_family="Alu" /rpt_type=dispersed misc_feature 10639..12307 /gene="PTGES" /note="Region not scanned for variation" repeat_region 10735..11026 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11997..12255 /rpt_family="Alu" /rpt_type=dispersed variation 12494 /gene="PTGES" /frequency="0.05" /replace="G" variation 12507 /gene="PTGES" /frequency="0.02" /replace="T" repeat_region 12526..12847 /rpt_family="Alu" /rpt_type=dispersed variation 12789 /gene="PTGES" /frequency="0.10" /replace="A" repeat_region 12949..13246 /rpt_family="Alu" /rpt_type=dispersed variation 13006 /gene="PTGES" /frequency="0.04" /replace="A" variation 13144 /gene="PTGES" /frequency="0.01" /replace="C" variation 13198 /gene="PTGES" /frequency="0.04" /replace="G" variation 13204 /gene="PTGES" /frequency="0.04" /replace="T" variation 13207 /gene="PTGES" /frequency="0.04" /replace="A" variation 13209 /gene="PTGES" /frequency="0.04" /replace="T" variation 13211 /gene="PTGES" /frequency="0.04" /replace="C" variation 13291 /gene="PTGES" /frequency="0.03" /replace="C" variation 13334 /gene="PTGES" /frequency="0.01" /replace="A" variation 13452 /gene="PTGES" /frequency="0.02" /replace="G" repeat_region 13547..13743 /rpt_family="L2" /rpt_type=dispersed variation 13730 /gene="PTGES" /frequency="0.05" /replace="G" variation 13874 /gene="PTGES" /frequency="0.02" /replace="G" variation 13944 /gene="PTGES" /frequency="0.03" /replace="T" variation 14263 /gene="PTGES" /frequency="0.05" /replace="G" variation 14361 /gene="PTGES" /frequency="0.08" /replace="T" repeat_region 14570..14678 /rpt_family="MIR" /rpt_type=dispersed variation 14869 /gene="PTGES" /frequency="0.03" /replace="C" variation 15256 /gene="PTGES" /frequency="0.01" /replace="T" variation 15281 /gene="PTGES" /frequency="0.33" /replace="G" variation 15422 /gene="PTGES" /frequency="0.01" /replace="A" repeat_region 15629..15738 /rpt_family="MER1_type" /rpt_type=dispersed variation 15659 /gene="PTGES" /frequency="0.06" /replace="T" repeat_region 15739..16030 /rpt_family="Alu" /rpt_type=dispersed variation 15878 /gene="PTGES" /frequency="0.03" /replace="A" repeat_region 16031..16094 /rpt_family="MER1_type" /rpt_type=dispersed variation 16094 /gene="PTGES" /frequency="0.02" /replace="A" variation 16182 /gene="PTGES" /frequency="0.04" /replace="T" variation 16190 /gene="PTGES" /frequency="0.01" /replace="T" variation 16314 /gene="PTGES" /frequency="0.16" /replace="T" variation 16336 /gene="PTGES" /frequency="0.02" /replace="C" repeat_region 17200..17260 /rpt_family="MIR" /rpt_type=dispersed repeat_region 17261..17544 /rpt_family="Alu" /rpt_type=dispersed misc_feature 17375..17767 /note="Region not scanned for variation" repeat_region 17545..17601 /rpt_family="MIR" /rpt_type=dispersed repeat_region 17770..18079 /rpt_family="Alu" /rpt_type=dispersed variation 17942 /frequency="0.01" /replace="A" BASE COUNT 3898 a 4979 c 4899 g 4773 t ORIGIN 1 tgaccttgtg gaggtcctgc cagaacccgg ggaagcgggc aggatgcagc aaggtgagga 61 ttttttttga gacagagtct cggtctgtcg cccaggctgg agtacagtgg tgcaatcttg 121 gctcactgca cctccacctc ccaggttgaa gcgattctcc cgcctcagcc tcccaagtag 181 ctgggattac aggtgtctgc catcacatct ggctaatttt tgtattttta gtagagaggg 241 gatttcacca cgttggccag gctggtctcg aacttctgac ctcagataat ctgcccccct 301 cggcctccca aagtgctggg attacatgtg tgagccacct ggccaaggtg aggattttga 361 ggtgagggat tcaaagaatc ttagaaaaca aacgttgatg ctttctttct tttttgagac 421 agggtcttgc tctgtcaccc aggctagagt gcagtggtga gaacatggct cactgcagcc 481 tcagcctcct gggttcaggt gatcctccca cttcagcctc ctgagtagct gggaatacag 541 gcgagcacca ccatgcccag ctaattaaaa catttttttg tagagacgga gtctccctat 601 gttgcccagg ctggtcttga acttctgact tcaggtaatc tgtccccctt ggcctcccaa 661 ggggctggaa ttacaggtgt gagccaccgc gcccggcctg gtgatgcttt ctactgaaga 721 gtcagttgat aggtctttcg gggagatctt gtgatgaaga atcaaagcat ttgactgggg 781 aaagagttcc aggatagtca agtgatgctc aggaagtcag tggagccacg tgctggttcc 841 ccatccctgc tatagcaaat taccacagac ttagtggctt aaaacaacac agcttcattc 901 tctgacagtt ctggtggatg aagcctgaaa tgggtctcac agggctaaaa tcaaagtgtc 961 gggagggctg cgttctgtct gaacgcagag agtttgtttc gtcccctttt ccagtttcta 1021 gaggcccctg gtattccttg ggccatgatc tctccttcat cttcaaggcc agcaggttag 1081 cgtctctcct gtctgacccc tattctgtcc tttcatctcc tctcttaatg ctgcctctgt 1141 ttttatatct tttctctaat tttactgcct ccctcttgga agggcccctc tgtatactct 1201 gggctcaccc agataaacta ggataatttc tcccatctca aatccttacg aaatcccatg 1261 tgaaaagtcc cttttgccac atagtcacag tcacgggttc tagggattgg gacatggatg 1321 tctttagggg tggagggcgt ccttcagcct gccacagatg gcaaagtcat gccattgtgg 1381 ctgcagctcc attgtccagg ctgagtgtgg gggcgcatgg cgtggttctc atgcccacca 1441 cctaccctga ccctgcggag gtgggcagga ggcagcgata atcaccacgt gcagaggtcc 1501 tgccaggtgc ccagcctcat cattccctag aaggcaggca ccaccacatg ctcccacact 1561 gtagataagg aaacagcttt gaaacagatt tgaaagtgtt tgaggatttg cctggaagga 1621 gggctccaga gccagggact gggtccggga cacccggaga ctctctgctt cttggagctc 1681 cggcaactgc ttgtctttct cttcacagga gaagggggcc ctgctgccgc tgccgtgggg 1741 cggggcgtgg gcggtgctgg ctgcaggaag gctctcccct cccactttgt gctttccctg 1801 caggctgctc ctctgtcgag ctgatcacac ccacagttga gctgcgctgg ccagagatgc 1861 ctgcccacag cctggtgatg agcagcccgg ccctcccggc cttcctgctc tgcagcacgc 1921 tgctggtcat caagatgtac gtggtggcca tcatcacggg ccaagtgagg ctgcggaaga 1981 aggtatgtgc ctccctgggg gtccccggcc tgggtcatac ttgcttctct ccacgtcctg 2041 tcaggaaagc cccgggatag ggaaacatgg ccaaggtgtg tgcagggctg ggaggtgagc 2101 acctcttcca gccccgccgg ggggcttcct gccagtccca cgtgtcagca aggcctgcac 2161 cttctcctct ctggcttaag agcacttact cgcttgccgt gccaccgggc tgagttcttg 2221 gcatggagag agccagcgag tgtctgtgag agaagcaggt tctggagggt ggagtgtggg 2281 agcgtgacag cacaaagcct ctgtctaacc tggtggcttc ccggcacggg aggtctgata 2341 tctgggtgga gtgggaaccg gcaaaacagg agtccgagaa acgtttaagt ggaaattccc 2401 aactcctggc aaatgtcact aacaagccca ctgtagcctc caaaggccag ctcccagccg 2461 ggcaccgtcg gggtgctcag cgaggaattt ccccactaat ccgagcccct gaaccaaaac 2521 aacattaacg agtcccagag ctgggccggg gcaagttcca gtagcgtccg tcacactggt 2581 tggcgagtct gcaaagtcat aggctgagct tgtcggctgt cctggcggca gaatgcagaa 2641 agaccccagg cacctgttac ttcctcccca ggtattttaa taaagcaatc atttcctgaa 2701 actgtctctg tcttcccctg tgtccagttc aaaggcgagg tgaggcaagg ctggctctgg 2761 cactgcatgc gggtggatcc tggggagtga ggatcttggc cacaagccag gctcaggccc 2821 tgctgcaggt acaggcagga ttaaaggcag ggcagctgcc caagtgatag gatgcccgga 2881 ggctacagca cactgatagc ttctgacttc tccctgcctt ggctggtcct gggatatggg 2941 atccgggcat caagtagaac agctgcattc actcattgaa tccttcccag aggaccgaat 3001 gtggcccgga gctgagcatg agatccccgc cacagccctg agggcagggg aggcgccata 3061 gtcatcctgt tttctaggtg aggaacctgg gctcagagag gagacatcac ttatgaaggt 3121 cacacagccc ggtttgaact ccagtgtcca gcttcagagc ccacatcctg tcttggaggc 3181 gggggtttct gttttgtttt ttttttctgc tgtccaggct ggagtgcagc ggcatgatct 3241 ctgcttactg caacctccac ctcctgggtt caagcaattc tactgcctca gcctccccgg 3301 tagctggcat tacagacaca caccaccatg ccctgctaat ttttgtattt ttagtagaga 3361 tggggtttca ccatgttggc caggctggtc ttgaacccct gacctcaggt gatccacccg 3421 cctcagcctc ccaaagtgtt ggaattacag gcgtgagcca ccgcacctgg ctgaggcctg 3481 ggttcttacc agcaggccag cgattccttt tttttttttt tttttaatta ttatttattt 3541 attttagaga cagggtcttg ctctgtggcc caggctggag tgcaattgtg cgatcatagc 3601 tcactgtagc ctcgacttcc tgggctcagg tgatcctccc acttcagcct cccaagtagc 3661 tgggactata ggtgtgcgtc actgctccta attttttatg tttttggtag agatggcttt 3721 tgccatgttg cccaggctgg tctcaaactc ctgggctcaa gtgatcctcc catcttggcc 3781 tcctggagtt ctgggattac aggtgtgagc cactgtgccc agctgtgatt tccttttaac 3841 acgaattcgg ggaagggagg aggtgaacct gtcccagagc ctttctgcct gattggcagg 3901 gacaccgcag aaggaaaccc ccactccttg ggctgctcct gaggtgttcc tcatgacaac 3961 gtggccccct cttatctctg ctctgggcgc taagtatcat ccaggaagga cttgctggag 4021 gtgacagtca caggccctgg ctcctccacc caccagcctg gggacctgga aaagtctggg 4081 agctcagtgt cctcacctgt aaacgggggt cgtgacagca gcgccaggag aatgcaacgc 4141 cccaccaatg tttgtcctta agacttataa gtaactgaaa ttaacatgag catcgcagcc 4201 tcaggtcact ttcaagggac ctcaaccaaa ggctggcctc caccccagct aaggtggcac 4261 ctcggccgct gacactgggg gcttcctggc ctgcactgca gctggctctg gcctggctga 4321 cttgtatctg agttgtatct ccagggggag caactccatg ggcagtggac tcctaaaggc 4381 agtgcccact gtatgctgag gccccttgaa acgtatcaca gatccacgga cagagccttc 4441 ggtgttggtg attcactgat ttcagggcca gcagagagga attttgggtg tgaaggttcc 4501 aatctcgaag atctgagctg cattctcctc tggggtaggg cagggcaggc ccaccaggga 4561 ggacaaacca gcccttgggg gacagtcatg agtcagaagc acaggatttg ccgtcagctg 4621 aacaatttag aaaacctgct cctgagattc aggctctgct gtgggcctgg tggggtctga 4681 ctgtctggat gccagcaggg aacagtggag caagagtcat gggcctctga tgatctcagt 4741 gtgactttat gtctctgctt tccaatgaga gaaagtgaca attcactgag cacctccttg 4801 tgctgggcat tgtcctagcg gcttctccag gtctccctct cactcgtcac acagcacatg 4861 agctgtgatt tctcctgagt tttcagagtt caggatcctg tggttaatca gcgcggagct 4921 gggttttcag cctggggctc tcaagacctt ctcatggctt ttagtgcaaa gtccaaattc 4981 ttcaggtgct gccaggaccc ctgatgaccc ctgtcccttt atcttgggcc cctgtccctt 5041 gccctctgtg ctcccgtgtg ctggttttct gttcttcaca catgcccagc ttcttccagc 5101 ctcagggcct ttgcacgtgc tgtcccttct gccttgaatg ttgttgctcc agccctccct 5161 tcatctggtt aatgtcaatg catctttcaa gcctcagatt gtttgtttta ttttttttgg 5221 agacagagtc tggctctgtt gcccaggctg gagtgcagtg gcaagatcac ggctcattgt 5281 agcctcgacc tcccaggctc aagcaatcct cctgcctcag ccctcctgcc aagtagctgg 5341 gaccacaggt gtgtatcacc acacacagct aatttttgta ttttttatag agggggtttc 5401 atcatgttgc ccaggctggt cttgaactcc tgagctcaag tgatccaact gcctcggcct 5461 cccaaagtgc tgagattaca gacatcagcc actgtaccca gcttgtttgt ttgttttaga 5521 gatggggtct tgctatgttg cccgggttgg tctcaaactc ctggaagctc aagcaatcct 5581 cctatcttgg cttcccaaag tgcttggctc acaggcgtga gccaccacac ctggcttgtt 5641 ttagagatgg ggtcttgcta tgttgcccag gctggttttg aactcctggg ctcaagcaat 5701 ccccctgcct tggccttccg aagtgctggg attactggtg tgagccacct catccagccc 5761 taagcctcag ctttcatgtc actgcctcag agaaactttc tcagagcctc agactgggtc 5821 aggtcccacg taaacattct caaggccagc cgtgccttct tcttaacagg tgagacaccc 5881 tggccttccc tggttcatag gcaactcccc catcggactg tgagcttcat aaaagcagag 5941 acaggggggc cttttcatgg tgagctacca gcccctggca cagggtagga atcgtggatg 6001 atggttggat gggtgtgtgt gcaactgcac ctctgtcctg ccactgtgaa ctctggtcat 6061 ggacaaaaca tagccccagg tgactgggcc gtttgtctca cgaggagtga ctctcaactg 6121 gtatatttca ggcctttgcc aaccccgagg atgccctgag acacggaggc ccccagtatt 6181 gcaggagcga ccccgacgtg gaacgctgcc tcaggcaagt acttcgggcc cctggcctgg 6241 ccacacctgg ccatggcctg ccctttcaga acttcttctg cacacagggg acttggagga 6301 ctcccagggg ctgaggtttt ctgtgttcct gatcttctct gactgtttta ctttattcaa 6361 tgatttaatt tcaaatgaac tttggaaaag taagacgtgg tcatgactca taattacaaa 6421 gtgagaaagg tggtgacttc agtgaacatt cagtctccct cctacctctg acctccaggc 6481 actacgcagt tctactggcc aggggcaaac actcctgcca atggccatgc atcttcccac 6541 agagatttgc tgcatttaca aacatgtgtg ccacgctttt cccgttctgc cccatagaat 6601 caccctttat cctctggtct gtactatgct tttttttttt tttttttttt tttaatatgg 6661 caacagagtt tgttccatat cggctcacag aggagttgca ttcactgtat tggtgctcca 6721 gtatttatgt tgccactctg ttgaatgtac agcccataac ttccctaacc aattcccctg 6781 cgatgggcat ttgggctcct tctgtgttat gaacagaagg cctcaatacc tctttttttt 6841 tttttttttt tttttttttg agacagagtc tcactctgtt gcccaggctg gagtgcagtg 6901 gtgccacctt ggctcactgc aacctccgcc acccgagttc aagcgattct cctgcctcag 6961 cctcccaagt agctggggct acaggcgtgc accatcatgc ctggctaatt tttgtatttt 7021 tagtagagat ggggtttcac tatgttggcc aggctggtct ggaactcctg acctcagatg 7081 atctgtccgc ctcggcctcc caaactgcta ggattacagg catgagccac cgcacccggc 7141 ctcaacactt ttttcatttg cctttatggg tatgtgtgag taaaaccgca ggatgcaaca 7201 aaatcatgtc ccactactgg tgtgggagcc atttttccat ccctctgaca atgcaactga 7261 caactcattg tattggcata tttgggtgga ttcctaccaa ggtgataggt gaaaatttat 7321 atcacatttt tgttttgctt tgcacttctt tattcttagt gaagttgaac atcttttcat 7381 atgcttaaca tccccctggt caattaaaat gaatttcctc attataaaaa tcagaactca 7441 ttacagacga tttgggtaat actgaaaaaa cacagagaca gaaaggaaaa ccactcacag 7501 ttctaatcac agttcacact tgcatctctc tcctctttgt cttctatagc taaatatttt 7561 ccataaaatt aggcatgcat taggtacacc caatttggag ttctgatttt cttttattaa 7621 cattattttg cgaacacttt ccatgttggt aaatgttact aaaaaaatta ttcttgacca 7681 gatgtggtgg ctcatgccta taatcccaac attttcgagg gccggcagat cacttgaggt 7741 caggagttct aggccagcct ggccaacatg gcgagaccct gtctccacta aagatacaaa 7801 aattagccgg gcatggtggc acgggcccgt agtcccagct actcgggagg ctgaggcggg 7861 agaatggcat gaacccagga ggcggaggtt gcagtaagcc aagattgcgc cactgcgctc 7921 cagcttgggg gatagagtga gactccatct caaaaaaaac aaaagatcct taaaaaactg 7981 gcttcgtaaa atcccatcag agactaaatg ctaatttcac ataatcacag tcaatattaa 8041 atttttttgg cagtttctgc tctgccatct tttaccagtt agctggagag tgaggcgatg 8101 gcactccagg ggttggggtc atcggaagag cttgaagggg aagtggggag gacggagagc 8161 tggacaggct gaggccggag acaaactgtc tcatgggtct caacacattc ccctgcatca 8221 caggcggaaa tgggtgggac actgtcattt aaataataca aatttctttc acttgaaaga 8281 aagtctgtgg gttttttttc ttatgttttt cttggccatt gacaataata tgtccacttg 8341 tggttttaaa aaaattacag acctgtgtca tgtaggaagt gaaattcctt gctattttac 8401 cctttcaaat ccttcatatg aggcccgtct ctccattaat gagcccttac tacatcccag 8461 acactgtgct aagcactggc tgtactttca agaacaaaag ccttctccat acatgacttc 8521 cattggtgac tcttgtcccc agctgtggcg gccctcctgg acagtggaga aggatgggat 8581 gagctgtcca ggcagcagga ggccaggacg gtgggttgcc cggggccagc tcacagcagc 8641 caccaagagg atgcgttttg gctcctccca ggctgcagag gttttatgta gcaaagcttt 8701 catgtggcac aatgtggcac aggagtggcc aagtggcctt acagatactt ggtttatttt 8761 tactggctga aaccatgccc catggagaga cgatagaccc gggtggcgcc gagacatttc 8821 cacccaacca atcttttttt ttttttttga gacagagttt cgctcttgtc ccccaggctg 8881 aaatgcaatg gcacgatctc ggctctctgc aacctctgcc tcccgggttc gagcaattcc 8941 cctgcctcag cctcccgagt agctgggatt acaggcacct gtgaccacgc cagctaattt 9001 ttgtattttt tttttagtag agacagagtt tcaccatgtt ggccaggctg gtctcaaact 9061 cctgacctca ggtgatccac ctgcctcggg cttccaaagt gctgggatta caggcgtgag 9121 ccattgcgcc cagcccaaaa taacccctca tctacagtac tggggtttaa atggtagaaa 9181 ttcatttcag cactttctga gtgcgtctta tctaataata ctttatagcc atttggtgag 9241 gacttactgg aagccgactg tatactgggc ccaagtcaga cctggggagt gcctgggtcc 9301 cctgggcccc tcctctgcca cctgatttca cagaacctca tggaaacttg agtgtgcaga 9361 actaagagaa ttctatatcc tgccgtctgc taccggagaa ctggctggaa cccgaagggg 9421 gagaccacct ggaagcaaaa gttggttaaa tattagacca gggtttatgg tatgattcga 9481 gtcacccttc tgtcaaatag gaaagcactt cagtcttggt tcttggagca tgaatctgcc 9541 ttgcaggtta gcacatgctg cagtccaaat gtgagcctag ttctgggaga agccagggac 9601 tagccacctt ttcaggatac ctatccggag ttcccggcaa tgtgcgtctg ggccagaatc 9661 tgaggttggg tgtgtggaac tgcacggagg ggttacctgt gtggtcccaa agaagagagg 9721 caaacgtgcg acctaagctt ggagcatttc tgtttggagt gtatagactt aaactgagtg 9781 aactgatttg tcaggaaatt gggtcccaaa atgtcagccc tagaagtccc ttagatgtca 9841 tccagcatgt acattttgta catagtgaac gcagtcccag agagtgagag agatttgcct 9901 gaggccatgg agctaataag caccacagca gaactggagg tttccagcct aatactccct 9961 tccggctgca ccacgaagta ctcaaaaaaa attttttttt tttttgagat ggactttcac 10021 tcttgttgcc caggctggag tgcaatagcg tggtttcggc ttgctgcaac ctccgcctcc 10081 cgggttcaag tgattcttct gcttcagcct cctgagtagc tgggattaca ggtgcgcgcc 10141 accactcctg gctaatgttt gtatttttag tagatgcagg atttcaccat gttggctagg 10201 ctggtcttga actcctgacc tcaagtgatc cgcctgcctc ggcctcccca aagtgttggg 10261 attacaggca tgagccacct cgcccggtct tttttttttt tttttttttt tgtgacaggg 10321 tcttgctctg tcgcccaggc tggagtgcag tggaatcccg gctcactgat gccttgacct 10381 cctgggctca aacgatcttc tcacctcagc ctcctgagta gctgggacca cagacacgtg 10441 ccaccatgcc tggctaattt ttaaattttt attgttgtag agacgggatc ttgctatgtt 10501 gctcaggctg attccagcac ccaagtgatc ctcccacttc agcctgagat cacaggtgtg 10561 tgccaccaca cccagcccca taacgtgctt ttgattcatt tggccggagc atctgagggc 10621 agtcagaaag tctggcaaag ccaagagggt gaagtgagct ttagcgatgg tgtccaggac 10681 agggctggtg atggcgatgg aggagatggc ggcttgctta aaatctccct actcagtcaa 10741 gcacagtggc tcacatctgt aatccctgca ctttgggagg ctgaggcggg tagatcacct 10801 gagcttagga gtttgagacg agcctggcca acatggcaaa accctgtctc tactaaaaat 10861 acaaaaatta accaggcgtg gtggggctcg cctgtagtct cagctactca ggaggctgaa 10921 gcacgaaaat cacttgaacc caggaggtgg aggttgcagt gagccgagat cacgccactg 10981 cactccagcc tggggcacag agcgagactc tgtctcaaaa aaaagatctt cctactcagt 11041 gtccaggagt gttgtaagca ctttccagga attcactcac ttggcactct gaggaggggc 11101 ctggcactct cggctctgct cctgaggctg tccctctatg ggaaggcgat ttcactgtct 11161 tgtatacctg cctttgaaac gaagcaggca ctgcattgcg tcaaccctga tacaaagtca 11221 aggaaattgg ccccaccgtg gatgccagca gggctggggg agagaagagg agaccctgtg 11281 gagcggccag cagctgtccc tgtcctggcc atctggggat cactgtcctc accgctgtca 11341 cctatgcagg aaaatgcagc tggtgtggaa aagtctgtgg agggtgaagg caggcctgat 11401 gctgcaggag gcaatacaag tccagtctag taggaatttg ctttgggtgg cttttacctt 11461 aaaaaaatgg ttattatttg aatgatgcat ttcacccgag cacgtctgtg gtacgtgcct 11521 gcctccatgt ctctcggttt ggagcctgga ggtgggagga gggaggtgag ctttcttcca 11581 tcattccttg gtgtctccat tgctccctgt ccctggccac tgcggcctcg gaggggcccc 11641 tctgcggttt gagacagacc agacgagtga gggagggctg ggccagcccc aggggctgac 11701 agtcagagct cctgaccacc tctcctccca cgctggtgac cgctgaattg ctgcccaatg 11761 gctggaaata gaaggtgggg ctcagtcccc gctttttctg caaggcctgc tcctccccag 11821 cctgcagaca tgccaggcag agcaggatcc acgtctgcca tgaacttccc gtcttgttcc 11881 tccttcccac cctgtgttcc ccaacttctt tccttcaccc actcttcagg gtttggctat 11941 gtttgtgaac tatctgtact atgattctct taacagcttt ccaaacattg acttactctt 12001 tttttttttt tgagacggag tctcactctg ttgcccaggc tggagtgcag tggcgcgatg 12061 ttggctcact gcaacctctg tctcccgggt tcaagagatt cccctgcctc agcctcccga 12121 gtagctggga ctacaggcgc ctgccaccac gcctgactga tttttgtatt tttagtagag 12181 atggggtttc accatatcag ccaggatggt ctcgatctcc tgacctcgtg atccgcccgc 12241 ctcagcctcc caaaggactt actcttaaaa tatcaacaca tactttaagg aatagctgag 12301 tgaacgagtt gcatatgctg gttgtgcttt tcctgaaact ttcaaataaa cattacaaaa 12361 ctcctcatcc aggtggcact cccttgtgaa tcacttgtga caggcagacc tcattttggg 12421 acataatcaa aaatgggttt tccaagggtg tccctctaat cagcctgtag ggggatgtgg 12481 gtacccacag ctcaattgcc agaggacgga gtgatttttg ttttgtttta tgtttttttt 12541 tttttttttt ttttgagaca gagtctcact cactctgtcg cccaggctgg agtgaagtga 12601 cacgatcttg gctcactgca acctccacct cccaggttta agtgattccc tgcctcagcc 12661 tcctgagtag ctgggaacta caagcacaca ccaccatgta cagctaattt tttttttttg 12721 tacttttagt agagatggga ttttgccatg ttggccaggt aggtctcaaa ctcctgtcct 12781 caagtgatcc accagcctca gcctcccaaa atgctgggat tacaggcatg agccactgca 12841 cccggccaag gatggagtga ttttggagga acacctattg cctttcctca tcagtcctgg 12901 taagggactt acttgacagg gaggtggccc cagtctttgg tttctccctc tcttttattt 12961 tatttattta tttttttgag agggagtttc cctctttttg cccaggctgg agtacaatgg 13021 catgatctca gctcactgca atctccacct gcccggttca ggtgattctc ctgcctcagc 13081 ctcccgagta gctgggatta caggcatgca ccaccatggc tggctaattt tgtattttta 13141 gtagagacag ggtttcacca tgttggccag gctggtctcg aactcctgac ctcaggtaat 13201 ccgcccgcct tggcctccca aagtgctggg attacaggcg tgagtctgta atctccctct 13261 tatgtcttcc ctgagggcag taccccagga tctatccaga gccagcctct gacagacaca 13321 ggcaggccac agtgttcccc accgctgggt gagaactgcc ctgccacaga cttgctttcc 13381 ttgtgtctgg gttgcaaggt caggatctgg gggaaaagga gaagaggggt tcatgtcagt 13441 ctcgggatat gcggacccag atgccaggtg ctgtgtcctg agtttggcct gagaaagatc 13501 taggccctgc tgggtttaca ggagttttgt acactcagat tgaattcctc tccctctctt 13561 atctgcctca ctccctcttg tgcaccgcac tgtagccatg ggctcacctt tctgcacatt 13621 gaacatgctg tgcttattgt gacctcagga cctttgcaca cactggtctt ccttcctgga 13681 atgcttttcc cctgcagggc cagcttctca tcattcaggc ttctgcacat atgtctcctt 13741 ccctgcccac ccccacccca ggcacgctgc agagcttcct acagtgtggg gtggccaagc 13801 actccaggcc ccctctttcc ttttggtcag gcccacacac catcgcactg gcccaagaat 13861 cgtcttgcca gtgagaggga agaggaggac cctgcagcgg gtccccactc agtgctgcta 13921 gtctgggcct ggcccgagga gacggtgtta ttggtggaat gtatgtcagc aggaaggccc 13981 ggagaacatg cttctgttcc tgcacctcac acgcgtggcc tgtccttggg ggaggtcatg 14041 ccctgggcac tgaattcctg tttatttgag cttccaatgt ggcaatctat gggtttagtt 14101 gctcattcag tctctaattt atgggactca acctccccac ccttcataaa ggaagccggc 14161 cattagtagg agtctggaaa atgtgaacca gcagaagtag gtgagttttc tgagttttct 14221 ttcttggtca tttatttatg gtggggttat acagagcccc tccgccccca ccacacatat 14281 gcacatgctt gattcctttc aacagaaaaa gaggcaggaa aggatgtgta aaatgaagag 14341 cttcaccggg ggctggccat cggttggctc cagtgagtgg gagcggatct tgttatgatt 14401 gtccctgaaa ggacaggtgg tagttagatt tagggggaaa aggagacaga gcccggcatt 14461 catttcaaag gcctgctctt gggctctagc cccttctact cgggaggggc ccaggaagct 14521 gcattcagaa ggaggatgac ctcaggcctg actcagagaa gccctgccct ggaggtaaag 14581 agcacaaact ccagtcagaa ctcggttcca atcccagctc ctccactcgt tggctctgta 14641 aagcactcag cacctctgag tcccactttt cctgcctggt atccaagggc tagagaggaa 14701 ggtgggggag agtatggcag gagtggggtc ccggcaagcc atagaggtat ggtaagagca 14761 tcctggacca gtagccctct gactcccagc ccatgacgtg gcctcgctgc ctcagctgct 14821 tgcaagcata agcttggagc tgccttcttc tggactctgg ggtatccatc tccttgacct 14881 ggctgtgaat ggatttgagt gtgtgatatg cctgaaatga cccccagtgg gtcaaagcac 14941 ccccagcttc catgacactc tcaaaagggc ctatggcccc aaagctaata cctggctgac 15001 cgcacccctc ttgtctcccc agggcccacc ggaacgacat ggagaccatc taccccttcc 15061 ttttcctggg cttcgtctac tcctttctgg gtcctaaccc ttttgtcgcc tggatgcact 15121 tcctggtctt cctcgtgggc cgtgtggcac acaccgtggc ctacctgggg aagctgcggg 15181 cacccatccg ctccgtgacc tacaccctgg cccagctccc ctgcgcctcc atggctctgc 15241 agatcctctg ggaagcggcc cgccacctgt gaccagcagc tgatgcctcc ttggccacca 15301 gaccatgggc caagagccgc cgtggctata cctggggact tgatgttcct tccagattgt 15361 ggtgggccct gagtcctggt ttcctggcag cctgctgcgc gtgtgggtct ctgggcacag 15421 tgggcctgtg tgtgtgcccg tgtgtgtgta tgtgtgtgtg tatgtttctt agccccttgg 15481 attcctgcac gaagtggctg atgggaacca tttcaagaca gattgtgaag attgatagaa 15541 aatccttcag ctaaagtaac agagcatcaa aaacatcact ccctctccct ccctaacagt 15601 gaaaagagag aagggagact ctatttaaga ttcccaaacc taatgatcat ctgaatcccg 15661 ggctaagaat gcagactttt cagactgacc ccagaaattc tggcccagcc aatctagagg 15721 caagcctggc catctgtatt tttttttttc caagacagag tcttgctctg ttgcccaagc 15781 tggagtgaag tggtacaatc tggctcactg cagcctccgc ctcccgggtt caagcgattc 15841 tcccgcctca gcctcctgag tagctgggat tacaggcgcg tatcaccata cccagctaat 15901 ttttgtattt ttagtagaga cgggttcacc atgttgccca ggagggtctc gaactcctgg 15961 cctcaagtga tccaccggcc tcggcctccc aaagtgctgg gatgacaggc atgaatcact 16021 gtgctcagcc accatctgga gttttaaaag gctcccatgt gagtccctgt gatggccagg 16081 ccaggggacc cctgccagtt ctctgtggaa gcaaggctgg ggtcttgggt tcctgtatgg 16141 tggaagctgg gtgagccaag gacagggctg gctcctctgc ccccgctgac gcttcccttg 16201 ccgttggctt tggatgtctt tgctgcagtc ttctctctgg ctcaggtgtg ggtgggaggg 16261 gcccacagga agctcagcct tctcctccca aggtttgagt ccctccaaag ggcagtgggt 16321 ggaggaccgg gagctttggg tgaccagcca ctcaaaggaa ctttctggtc ccttcagtat 16381 cttcaaggtt tggaaactgc aaatgtcccc ttgatgggga atccgtgtgt gtgtgtgtgt 16441 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gttttctcct agacccgtga cctgagatgt 16501 gtgattttta gtcattaaat ggaagtgtct gccagctggg cccagcacct cgtcttgggt 16561 tgcgcgttcc tggtgttccc tgctgcccaa gctggcctga tgctccagcg cgctgggcgt 16621 tcttgccggt gactgtctac agccagtttg gcgggacaag atctctggcg cagacaccaa 16681 cgcgccctgg ctgggtgtta atcacacagc aagcagcagc ctcctgcctc ccgttggggc 16741 gggtaaggtg gcatctggcg aggtgagcca ggagcaccca aatcctgccc cggccaggtc 16801 acccctccct gcggggctgc cccgcccgcg ggctgccatt atcagctccg tcaaccagga 16861 cacggagact ccaggaggcc agcgcccgga agtgcggggc caggtctgaa agtcggggct 16921 gccaaagtcc ctgggcggag cccctgtgct gcacggcctc actttccctg aacgccccct 16981 cccagcaccc cgaggccgga gcccctctaa cggatgggac ctgccgtgcc gggggttctc 17041 cagcagcgca gggaccccag gccccgccag aaagcgccgt gaggccccgg gtcccgttcg 17101 gagctgagag gggaaacact gccccctggt ggtaagggga cgcctctgtt tttgggccgc 17161 ggcggctctc gggagagaaa cgggaagggc gcgatccagt attgagcacc tactgcttgc 17221 taagcgttgg gctgggcata ctagttggat ttttttccaa cttatgtctg taattcaagc 17281 actttgggag gccgaagttg gaagatctga gcccaggggt ttgagactag cctgggcaac 17341 agagctagat cccttttcta ccaaaaaaaa aaaaaagaat tagccgggtg taatggtgcc 17401 tgcctatggt cccagctact cgggaggctg aggcaggagg atcgcttgag cctgggaagt 17461 tgaggctgca gtgagccgag atcccaccac tgcactccag cccgggcaac agagggaaaa 17521 tgtctcaaaa aaaaaaaaaa aaaatcccca aaacaatccg aggcaggagg gatttccgct 17581 ttctagatga ggaaggtgag ggtttttaga tgagagaggc aaggttcaca ggaaggaggc 17641 ttgtaggggg tgtctcctca caggggagag gtgacttgcc tgctgtccct gggctcggac 17701 agtgtaaggc cagagggagg acagatccca gggcaggggc catccaggag gcgaacccag 17761 cgtgcattct tgttgttgtt gttgttgttg tttgagatgg agtctcactc tgtcacccag 17821 gctggagtgc agtggtgcca tctcggctca ctgcaacctc tccttcccag gttcaaacca 17881 ttctcctgtc tccgcctccc gagtagctgg gattacatac aggcatgtgc caccacaccc 17941 ggctaatttt tatattttta gtagagacag ggtttcacca tgttggccag gctggtctcg 18001 aactcctgac ctcaagtgat ctgcctgcct cagcctccca aagtgctggg attacaggag 18061 tgagccaccg tgcctggcca cagcagcgtg cgcttttata tttatatttt ccttcctggg 18121 gaaagagggg ctctgtgggc aaaataacct gctgggaacc caccggaccc aggtgagcag 18181 gggcatcgga tgcccatggc aatactgtga acctggggcg tgggtgaagg aggcggcccc 18241 caccacactg gagccgcaga gaccacgaga ccatgaggtc ccctgcccgg caccgcccct 18301 gttctgtcgg cttgtgagtg cctcctcagg gtggggtggt gcccgatgct ggggtggcaa 18361 cctcatcctg ccccccgtcc ccatgcatgc agctccagcc tggggtgggc gggctccgca 18421 ggacggcgcc cgtgatgacc ccaaggctca gcgccctgat ggaggcagat ggggcctttt 18481 aacccctgct ggggagcggc tgcctgggga gggggcaact cacctgcggt ggggggtgaa 18541 agagcggtt //