Hugo        AllelePos a.a.Pos Residue   Variant   ADfreq    EDfreq    PPHpredict              SIFTpredict   
PCSK9       002430    47      R         L         0.00      0.02      possibly damaging       TOLERATED     
PCSK9       002451    54      A         V         0.02      0.09      benign                  INTOLERANT    
PCSK9       020593    426     N         S         0.02      0.00      benign                  TOLERATED     
PCSK9       020646    444     A         T         0.06      0.00      benign                  TOLERATED     
PCSK9       021028    475     I         V         0.21      0.13      benign                  TOLERATED     
PCSK9       022104    554     H         R         0.02      0.00      possibly damaging       INTOLERANT    
PCSK9       024013    620     Q         P         0.02      0.00      possibly damaging       INTOLERANT    
PCSK9       025978    671     E         G         0.38      0.02      benign                  INTOLERANT