LOCUS AF372214 8019 bp DNA linear PRI 01-JUN-2001 DEFINITION Homo sapiens interleukin 6 (IL6) gene, complete cds. ACCESSION AF372214 VERSION AF372214.2 GI:14278708 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 8019) AUTHORS Rieder,M.J., Carrington,D.P., Chung,M.-W., Lee,K.L., Poel,C.L., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (18-APR-2001) Molecular Biotechnology, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA REFERENCE 2 (bases 1 to 8019) AUTHORS Rieder,M.J., Carrington,D.P., Chung,M.-W., Lee,K.L., Poel,C.L., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (01-JUN-2001) Molecular Biotechnology, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA REMARK Sequence update by submitter COMMENT On Jun 1, 2001 this sequence version replaced gi:13899130. To cite this work please use: SeattleSNPs. NHLBI Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.mbt.washington.edu). FEATURES Location/Qualifiers source 1..8019 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 95 /frequency="0.07" /replace="C" variation 205 /frequency="0.23" /replace="-" variation 276 /frequency="0.01" /replace="A" variation 321 /frequency="0.07" /replace="T" variation 657 /frequency="0.02" /replace="-" variation 1086 /frequency="0.24" /replace="A" variation 1111 /frequency="0.03" /replace="C" variation 1494 /frequency="0.01" /replace="T" variation 1510 /frequency="0.24" /replace="C" gene 1685..6481 /gene="IL6" mRNA join(1685..1765,1928..2118,3177..3290,3998..4144, 5890..6481) /gene="IL6" /product="interleukin 6" variation 1699 /gene="IL6" /frequency="0.01" /replace="A" CDS join(1747..1765,1928..2118,3177..3290,3998..4144, 5890..6057) /gene="IL6" /note="interferon, beta 2" /codon_start=1 /product="interleukin 6" /protein_id="AAK48987.1" /db_xref="GI:13899131" /translation="MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHR QPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCF QSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKN LDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM" variation 2002 /gene="IL6" /frequency="0.02" /replace="T" variation 2187 /gene="IL6" /frequency="0.01" /replace="T" variation 2190 /gene="IL6" /frequency="0.01" /replace="A" variation 2298 /gene="IL6" /frequency="0.26" /replace="A" variation 2529 /gene="IL6" /frequency="0.26" /replace="C" repeat_region 2647..2819 /rpt_family="MIR3" /rpt_type=dispersed variation 2693 /gene="IL6" /frequency="0.01" /replace="T" variation 2736 /gene="IL6" /frequency="0.02" /replace="C" variation 2773 /gene="IL6" /frequency="0.26" /replace="C" repeat_region 2859..3028 /rpt_family="MIR" /rpt_type=dispersed variation 2883 /gene="IL6" /frequency="0.01" /replace="T" variation 2892 /gene="IL6" /frequency="0.08" /replace="G" variation 2989 /gene="IL6" /frequency="0.29" /replace="C" variation 3084 /gene="IL6" /frequency="0.04" /replace="T" variation 3114 /gene="IL6" /frequency="0.04" /replace="T" variation 3344 /gene="IL6" /frequency="0.03" /replace="T" variation 3360 /gene="IL6" /frequency="0.01" /replace="A" variation 3437 /gene="IL6" /frequency="0.27" /replace="G" variation 3572 /gene="IL6" /frequency="0.49" /replace="T" variation 3608 /gene="IL6" /frequency="0.05" /replace="A" variation 4175 /gene="IL6" /frequency="0.06" /replace="A" variation 4638 /gene="IL6" /frequency="0.19" /replace="C" repeat_region 4841..4935 /rpt_family="MER5A" /rpt_type=dispersed variation 4859 /gene="IL6" /frequency="0.14" /replace="A" variation 4875 /gene="IL6" /frequency="0.19" /replace="A" variation 5014 /gene="IL6" /frequency="0.47" /replace="G" variation 5047 /gene="IL6" /frequency="0.01" /replace="C" repeat_region 5210..5345 /rpt_family="FLAM_C" /rpt_type=dispersed variation 5227 /gene="IL6" /frequency="0.01" /replace="G" repeat_region 5443..5727 /rpt_family="AluSx" /rpt_type=dispersed variation 5473 /gene="IL6" /frequency="0.03" /replace="A" variation 5602 /gene="IL6" /frequency="0.08" /replace="T" variation 5903 /gene="IL6" /frequency="0.02" /replace="T" variation 6021 /gene="IL6" /frequency="0.14" /replace="T" variation 6094 /gene="IL6" /frequency="0.01" /replace="T" variation 6169 /gene="IL6" /frequency="0.02" /replace="A" variation 6519 /frequency="0.03" /replace="T" misc_feature 6547..7039 /note="Region not scanned for variation" repeat_region 7041..7101 /rpt_family="MIR" /rpt_type=dispersed variation 7125 /frequency="0.03" /replace="A" repeat_region 7130..7231 /rpt_family="MIR" /rpt_type=dispersed variation 7150 /frequency="0.02" /replace="G" variation 7296 /frequency="0.02" /replace="C" variation 7480 /frequency="0.01" /replace="C" variation 7489 /frequency="0.03" /replace="C" repeat_region 7572..7834 /rpt_family="AluSx" /rpt_type=dispersed variation 7592 /frequency="0.24" /replace="A" variation 7659 /frequency="0.83" /replace="-" ORIGIN 1 tcgtcgaaaa tacatagacg gatcacagtg cacggctgcg gatagggagc agtggcttcg 61 tttcatgcag gaaagagaac ttggttcagg agtgtctacg ttgcttaaga caggagagca 121 ctaaaaatga aaccatccag ccatcctccc ccattttcat tttcacacca aagaatccca 181 ccgcggcaga ggaccaccgt ctctctgttt agacaatcgg tgaagaatgg atgacctcac 241 tttccccaac aggcgggtcc tgaaatgtta tgcacgaaac aaaacttgag taaatgccca 301 acagaggtca ctgttttatc gatcttgaag agatctcttc ttagcaaagc aaagaaaccg 361 attgtgaagg taacaccatg tttggtaaat aagtgttttg gtgttgtgca agggtctggt 421 ttcagcctga agccatctca gagctgtctg ggtctctgga gactggaggg acaacctagt 481 ctagagccca tttgcatgag accaaggatc ctcctgcaag agacaccatc ctgagggaag 541 agggcttctg aaccagcttg acccaataag aaattcttgg gtgccgacgc ggaagcagat 601 tcagagccta gagccgtgcc tgcgtccgta gtttccttct agcttctttt gatttcaaat 661 caagacttac agggagaggg agcgataaac acaaactctg caagatgcca caaggtcctc 721 ctttgacatc cccaacaaag aggtgagtag tattctcccc ctttctgccc tgaaccaagt 781 gggcttcagt aatttcaggg ctccaggaga cctggggccc atgcaggtgc cccagtgaaa 841 cagtggtgaa gagactcagt ggcaatgggg agagcactgg cagcacaagg caaacctctg 901 gcacagagag caaagtcctc actgggagga ttcccaaggg gtcacttggg agagggcagg 961 gcagcagcca acctcctcta agtgggctga agcaggtgaa gaaagtggca gaagccacgc 1021 ggtggcaaaa aggagtcaca cactccacct ggagacgcct tgaagtaact gcacgaaatt 1081 tgagggtggc caggcagttc tacaacagcc gctcacaggg agagccagaa cacagaagaa 1141 ctcagatgac tggtagtatt accttcttca taatcccagg cttggggggc tgcgatggag 1201 tcagaggaaa ctcagttcag aacatctttg gtttttacaa atacaaatta actggaacgc 1261 taaattctag cctgttaatc tggtcactga aaaaaaattt tttttttttc aaaaaacata 1321 gctttagctt attttttttc tctttgtaaa acttcgtgca tgacttcagc tttactcttt 1381 gtcaagacat gccaaagtgc tgagtcacta ataaaagaaa aaaagaaagt aaaggaagag 1441 tggttctgct tcttagcgct agcctcaatg acgacctaag ctgcactttt ccccctagtt 1501 gtgtcttgcg atgctaaagg acgtcacatt gcacaatctt aataaggttt ccaatcagcc 1561 ccacccgctc tggccccacc ctcaccctcc aacaaagatt tatcaaatgt gggattttcc 1621 catgagtctc aatattagag tctcaacccc caataaatat aggactggag atgtctgagg 1681 ctcattctgc cctcgagccc accgggaacg aaagagaagc tctatctccc ctccaggagc 1741 ccagctatga actccttctc cacaagtaag tgcaggaaat ccttagccct ggaactgcca 1801 gcggcggtcg agccctgtgt gagggagggg tgtgtggccc agggagggct ggcgggcggc 1861 cagcagcaga ggcaggctcc cagctgtgct gtcagctcac ccctgcgctc gctcccctcc 1921 ggcacaggcg ccttcggtcc agttgccttc tccctggggc tgctcctggt gttgcctgct 1981 gccttccctg ccccagtacc cccaggagaa gattccaaag atgtagccgc cccacacaga 2041 cagccactca cctcttcaga acgaattgac aaacaaattc ggtacatcct cgacggcatc 2101 tcagccctga gaaaggaggt gggtaggctt ggcgatgggg ttgaagggcc cggtgcgcat 2161 gcgttcccct tgcccctgcg tgtggccggg ggctgcctgc attaggaggt ctttgctggg 2221 ttctagagca ctgtagattt gaggccaacg gggccgacta gactgacttc tgtatttatc 2281 ctttgctggt gtcaggaggt tcctttcctt tctggaaaat gcagaatggg tctgaaatcc 2341 atgcccacct ttggcatgag ctgagggtta ttgcttctca gggcttcctt ttccctttcc 2401 aaaaaattag gtctgtgaag ctcctttttg tcccccgggc tttggaagga ctagaaaagt 2461 gccacctgaa aggcatgttc agcttctcag agcagttgca gtactttttg gttatgtaaa 2521 ctcaatggtt aggattcctc aaagccattc cagctaagat tcatacctca gagcccacca 2581 aagtggcaaa tcataaatag gttaaagcat ctccccactt tcaatgcaag gtattttggt 2641 cctgtttggt agaaagaaaa gaacacagga ggggagattg ggagcccaca ctcgaattct 2701 ggttctgcca aaccagcctt gtgatcttgg gtaaattccc taccacctct ggactccatc 2761 agtaaaattg ggggtggact aggtgatctc atagatcctt cctgctggaa cattctatgg 2821 cttgaattat attctcctaa ttattgtcaa aattgctgtt attaagtatc tactgtgtgc 2881 caggcacttt aaataaatat tgtgtctaat cttcaaaaca aatttgcaag gaaggttttt 2941 ggagataagg aaactgagac tcaggattaa gtaacacacc taaagtcaaa ggtgagcttg 3001 gaactgaacc caagtgtgcc cccactccac tggaatttgc ttgccaggat gccaatgagt 3061 tgtagcttca tttttcttag agactttcct ggctgtggtt gaacaatgaa aaggccctct 3121 agtggtgttt gttttaggga cacttaggtg ataacaattc tggtattctt tcccagacat 3181 gtaacaagag taacatgtgt gaaagcagca aagaggcact ggcagaaaac aacctgaacc 3241 ttccaaagat ggctgaaaaa gatggatgct tccaatctgg attcaatgag gtaccaactt 3301 gtcgcactca cttttcacta ttccttaggc aaaacttctc cctcttgcat gcagtgcctg 3361 tatacatata gatccaggca gcaacaaaaa gtgggtaaat gtaaagaatg ttatgtaaat 3421 ttcatgagga ggccaacttc aagctttttt aaaggcagtt tattcttgga caggtatggc 3481 cagagatggt gccactgtgg tgagatttta acaactgtca aatgtttaaa actcccacag 3541 gtttaattag ttcatcctgg gaaaggtact cgcagggcct tttccctctc tggctgcccc 3601 tggcagggtc caggtctgcc ctccctccct gcccagctca ttctccacag tgagataacc 3661 tgcactgtct tctgattatt ttataaaagg aggttccagc ccagcattaa caagggcaag 3721 agtgcaggaa gaacatcaag ggggacaatc agagaaggat ccccattgcc acattctagc 3781 atctgttggg ctttggataa aactaattac atggggcctc tgattgtcca gttatttaaa 3841 atggtgctgt ccaatgtccc aaaacatgct gcctaagagg tacttgaagt tctctagagg 3901 agcagaggga aaagatgtcg aactgtggca attttaactt ttcaaattga ttctatctcc 3961 tggcgataac caattttccc accatctttc ctcttaggag acttgcctgg tgaaaatcat 4021 cactggtctt ttggagtttg aggtatacct agagtacctc cagaacagat ttgagagtag 4081 tgaggaacaa gccagagctg tgcagatgag tacaaaagtc ctgatccagt tcctgcagaa 4141 aaaggtgggt gtgtcctcat tccctcaact tggtgtgggg gaagacaggc tcaaagacag 4201 tgtcctggac aactcaggga tgcaatgcca cttccaaaag agaaggctac acgtaaacaa 4261 aagagtctga gaaatagttt ctgattgtta ttgttaaatc tttttttgtt tgtttggttg 4321 gttggctctc ttctgcaaag gacatcaata actgtatttt aaactatata ttaactgagg 4381 tggattttaa catcaatttt taatagtgca agagatttaa aaccaaaggc gggggggcgg 4441 gcagaaaaaa gtgcatccaa ctccagccag tgatccacag aaacaaagac caaggagcac 4501 aaaatgattt taagatttta gtcattgcca agtgacattc ttctcactgt ggttgtttca 4561 attctttttc ctacctttta ccagagagtt agttcagaga aatggtcaga gactcaaggg 4621 tggaaagagg taccaaaggc tttggccacc agtagctggc tattcagaca gcagggagta 4681 gacttgctgg ctagcatgtg gaggagccaa agctcaataa gaaggggcct agaatgaaac 4741 ccttggtgct gatcctgcct ctgccatttc tacttaagcc agggtttctc atatgttaac 4801 atgcatggga attccctggg catcttcttg tggtgtggag tctgacttag caagcctcgg 4861 gtgggtttga gggtcaaatt tctaccaggc ttatatccct ggtgatgctg cagaattcca 4921 ggaccacact tggaggttta aggccttcca caagttactt atcccatatg gtgggtctat 4981 ggaaaggtgt ttcccagtcc tctttacacc accagatcag tggtctttca acagatccta 5041 aagggatggt gagagggaaa ctggagaaaa gtatcagatt tagaggccac tgaagaaccc 5101 atattaaaat gcctttaagt atgggctctt cattcatata ctaaatatga actatgtgcc 5161 aggcattatt tcatatgaca gaatacaaac aaataagata gtgatgctgg tcaggcttgg 5221 tggctcatgc ctgtattccc taaactttgg gagcctaagg tgagaactcc ttgaactcct 5281 aaggccagga gttcaagacc agcctggata acatagcaag accccatctc tacaaaaaac 5341 caaaaccaaa caaacaaaaa tgatagtggt gcttccctca ggatgcttgt ggtctaatgg 5401 gagacagaac agcaaaggga tgattagaag ttggttgctg tgagccaggc acagtgctga 5461 tataatccca gcgctatggg aggctgaggt gggtggatca tttgaggcca ggagtttaag 5521 accagcctgg tcaacatggt aaaaccccat ctctacttaa aaatacaaaa aagttagcca 5581 ggcatggtgg catacacctg taacccagct actcaggagg ctgaggcaca tgaatcactt 5641 gaacccagga ggcagaggtt gctgtgcacc actgcactcc agcctgggtg acagaacgag 5701 accttgactc aaaaaaaaaa aaaagaagtt tgttgctatg gaagggtcct actcagagca 5761 ggcaccccag ttaatctcat tcaccccaca tttcacattt gaacatcatc ccatagccca 5821 gagcatccct ccactgcaaa ggatttattc aacatttaaa caatcctttt tactttcatt 5881 ttccttcagg caaagaatct agatgcaata accacccctg acccaaccac aaatgccagc 5941 ctgctgacga agctgcaggc acagaaccag tggctgcagg acatgacaac tcatctcatt 6001 ctgcgcagct ttaaggagtt cctgcagtcc agcctgaggg ctcttcggca aatgtagcat 6061 gggcacctca gattgttgtt gttaatgggc attccttctt ctggtcagaa acctgtccac 6121 tgggcacaga acttatgttg ttctctatgg agaactaaaa gtatgagcgt taggacacta 6181 ttttaattat ttttaattta ttaatattta aatatgtgaa gctgagttaa tttatgtaag 6241 tcatatttat atttttaaga agtaccactt gaaacatttt atgtattagt tttgaaataa 6301 taatggaaag tggctatgca gtttgaatat cctttgtttc agagccagat catttcttgg 6361 aaagtgtagg cttacctcaa ataaatggct aacttataca tatttttaaa gaaatattta 6421 tattgtattt atataatgta taaatggttt ttataccaat aaatggcatt ttaaaaaatt 6481 cagcaacttt gagtgtgtca cgtgaagctt aatataaaca agtttcttgt cactgccacc 6541 accacgacca aaaaaagcta atcaatcact atatataata catatatata ctatatataa 6601 taaatatata tactatatat aatacatata tacactatat ataatacata tatactatat 6661 atacacatat atactatata tacacatata tattatgaat gtatatatat agtatatata 6721 gtatatatac tatgtatgta tatatatagt atatatagta tatatactat gtatgtgtat 6781 atatagtata tatagtatat atagtatata tactatgtat gtatatatat agtatatata 6841 gtatatatac tgtgtatgta tatatatagt atatatatac tatatatgca tacatagtat 6901 atatgcatat atactatata tactatatat ttatatatac tatatactat atatactata 6961 tactgtatat atactatata tgtatgtata cgatatatat atatactata tatgtacaca 7021 cacacatata tatatacata taagcaccta ctacatgcca ggcatcatta aatgtgttgc 7081 atccatcacg tcatttaacc ccagcacttg cacactcctt tctggttgtg gaagactaag 7141 taatttatct aagtcaccca gctggaaggt caggcaggga cccagatttg aaatccaagt 7201 ctacctacct acaggtcccc tactcttaac ctgtaggtcc cactgcctac ccaggaactg 7261 agggatgatg tagaaaatcc caaaacatgt taatataggg aatacctata aacatgcaat 7321 caaagtcttt gggactatac aaccactgta taaagcataa caatgtacaa gcttccaaac 7381 aataactaga agttctgcct ccctcttctg ggttcctaaa gcactgcacc tatctacctg 7441 tcaaagcatc taccacattg taccacacct taaaatcaat ggtttttttc ttctcagcca 7501 gcatgtggat gcctcaataa agcagactcc tttcatgacc taaaactaat ttcagggggg 7561 aaaaaaagac gagctgggcg cagtggctca cgcctataat cccagcactt tgggaggctg 7621 aggcgggagg atcacttgag gtcagaagac cagcctggcc caacatggca aaaccccgtc 7681 tctactaaaa atacaaaaat tagctgggcg tggtggcgca cctataatcc cagctactca 7741 ggaagctgag acatgataat cgcttgagcc tgggaggtag agcctggggc tgcactccat 7801 cctgggcaac agagggagat tctgtctcaa aaaataataa taataatata aataaataaa 7861 taattttttt aaaaaaagac tctttcctat attaatcttt gcatcctgtg cccatggccc 7921 caaacctgac caatgaaggc cccagtaaat attttttgaa caaaagaaaa tatagatgat 7981 caaagataag aaagataaga agacacctca attcttgta //