IL3RA Color FASTA
The longest form of insertion/deletion sites is shown in the FASTA sequence and contain a '-' as the alternate allele in the variation tag.
*Display courtesy of
GeneSNPs
C
G
G
G
C
T
G
C
A
A
G
G
T
G
G
A
G
G
C
T
C
T
G
G
G
G
A
A
G
G
G
C
T
G
A
G
G
T
T
G
G
G
G
T
G
G
A
A
T
T
50 |
NOT SCANNED
T
G
G
G
A
A
G
G
G
T
G
C
C
G
A
G
A
A
C
C
A
G
A
G
A
A
G
A
G
T
T
G
A
T
A
C
A
T
T
C
A
G
A
G
G
G
A
A
G
G
100
G
A
A
G
G
G
C
T
G
T
C
T
G
G
G
A
G
T
G
C
G
C
G
T
G
C
T
G
A
G
T
A
A
A
C
A
G
A
A
A
T
A
A
C
A
G
A
T
T
T
150
C
A
G
C
G
T
T
G
G
A
A
A
G
A
G
A
A
G
C
C
C
G
G
G
A
C
A
G
G
T
T
G
G
T
G
A
G
T
G
C
C
C
C
A
T
T
C
A
G
G
200
G
C
T
G
G
A
C
T
T
T
A
C
T
A
A
G
G
G
T
T
T
T
T
G
T
T
T
G
T
T
T
G
T
T
T
T
C
T
G
T
T
G
A
G
A
C
A
G
A
G
250 |
REPEAT
T
T
T
G
C
T
C
T
T
G
T
C
A
C
C
A
G
G
C
T
G
G
A
G
T
G
C
A
G
T
G
G
T
G
T
G
A
T
C
T
C
G
G
C
T
C
A
C
T
G
300
T
A
A
C
C
T
C
C
G
C
C
T
G
C
C
G
G
G
T
T
T
A
A
G
T
G
A
T
T
C
T
C
C
T
G
C
C
T
C
A
G
C
C
T
T
G
G
G
A
G
350
A
A
G
C
T
G
G
G
A
T
T
A
C
A
G
G
C
A
C
C
T
G
C
C
A
C
C
A
C
G
C
C
T
G
G
C
T
A
A
T
T
T
T
T
A
A
A
T
T
T
400
T
T
A
C
T
A
G
A
G
A
C
G
G
G
G
T
T
T
C
A
C
C
A
T
G
T
T
G
T
C
C
A
G
G
C
T
G
A
T
C
T
T
G
A
A
C
T
C
C
T
450
G
C
C
C
T
C
A
G
G
T
G
A
T
C
T
A
C
C
C
G
C
C
T
C
A
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
G
A
C
A
G
500
G
T
G
C
G
A
G
C
C
A
C
C
G
C
G
C
C
T
G
A
C
C
A
C
T
A
A
G
A
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
G
A
G
A
550 |
REPEAT
C
G
G
A
G
T
C
T
C
G
T
T
C
T
A
T
T
T
C
C
C
A
G
G
C
T
G
G
A
G
T
G
C
A
G
T
G
G
C
G
C
C
A
T
C
C
T
G
G
C
600
T
C
A
C
T
G
T
A
A
C
C
T
C
C
A
T
C
T
C
C
C
A
G
G
T
T
C
A
A
A
T
G
A
T
T
C
T
C
C
T
G
C
C
T
C
A
G
C
C
T
650
C
C
G
G
A
G
A
A
G
C
T
G
G
G
A
T
T
A
T
A
G
G
C
A
C
C
C
A
C
C
A
C
C
A
C
G
C
C
T
G
G
C
T
A
A
C
T
T
T
T
700
T
T
C
T
T
T
T
T
A
C
T
A
G
A
G
A
C
G
G
G
G
T
T
T
C
A
C
C
A
T
G
T
T
G
G
T
C
A
G
A
A
T
G
G
T
C
T
C
G
A
750
A
C
T
C
C
T
G
A
C
C
T
C
A
G
G
G
T
G
A
T
C
C
A
C
C
C
T
C
C
T
C
G
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
800
A
T
G
A
C
A
G
G
T
G
T
G
A
A
C
C
A
C
C
G
C
A
C
C
T
G
A
C
C
A
C
T
A
A
G
A
T
A
T
C
T
T
T
T
T
T
T
T
T
T
850 |
REPEAT
T
T
T
T
T
T
T
G
A
G
A
C
G
G
A
G
T
C
T
T
G
C
T
C
T
A
T
C
A
C
C
C
A
G
G
C
T
G
G
A
G
G
G
C
A
C
T
G
G
C
900
G
C
C
A
T
C
C
T
G
G
C
T
C
A
C
T
G
T
A
A
C
C
T
C
T
C
T
C
C
C
A
G
G
T
T
C
A
A
A
C
T
A
T
T
C
T
C
C
T
G
950
C
C
T
C
A
G
C
C
T
C
C
A
G
A
G
A
A
G
C
T
G
G
G
A
T
T
A
C
A
G
G
C
A
C
C
T
G
C
C
A
C
C
A
C
G
C
C
T
G
G
1000
C
T
A
A
T
T
T
T
T
A
A
A
T
T
T
T
T
A
C
T
A
G
A
G
A
C
G
G
G
C
T
T
C
C
A
C
C
A
T
G
T
T
G
G
C
C
A
G
A
T
1050
G
G
T
C
T
C
A
A
A
C
T
C
C
T
G
A
C
C
T
C
A
G
G
T
G
A
T
C
C
G
C
C
C
T
C
A
T
C
G
G
C
C
T
C
C
C
A
A
A
G
1100
T
G
C
T
G
G
G
A
T
G
A
C
A
G
G
T
G
T
G
A
G
C
C
A
C
C
A
C
C
C
C
T
G
A
C
C
ACTA AGATA
T
C
T
T
T
1150 |
REPEAT
T
T
T
T
T
T
T
T
T
T
T
G
A
G
A
C
C
G
A
G
T
C
T
T
G
C
T
C
T
G
T
C
G
C
C
C
A
G
G
C
T
G
G
A
G
T
G
C
A
G
1200
T
G
G
C
G
C
G
A
T
C
T
C
G
G
T
T
C
A
C
T
G
T
A
A
C
C
T
C
C
T
C
C
G
C
C
T
C
C
C
A
G
G
T
T
C
A
A
G
C
G
1250 |
var(1233):[A:0.32]
|
var(1239):[T:0.01]
A
T
T
C
T
C
C
T
G
T
C
T
C
A
G
C
C
T
C
C
C
G
A
G
T
A
G
C
T
G
G
G
A
T
T
A
C
A
G
G
T
G
C
T
C
A
C
C
A
C
1300 |
var(1278):[T:0.01]
|
var(1299):[G:0.06]
C
A
C
G
C
T
G
G
G
C
T
A
A
T
T
T
T
T
G
T
A
T
T
T
T
T
A
A
T
A
G
A
G
A
C
G
G
G
G
T
T
T
C
A
C
C
A
T
G
T
1350 |
var(1307):[T:0.23]
T
G
G
C
C
A
G
G
C
T
G
G
T
C
T
C
A
A
T
C
T
C
T
T
G
A
C
C
T
C
A
A
G
T
G
A
T
C
T
G
C
C
C
G
C
C
T
C
G
G
1400 |
var(1398):[G:0.05]
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
G
A
C
A
G
G
C
G
T
G
A
G
C
C
A
C
C
G
C
A
C
C
C
G
G
C
C
ACTA
1450 |
var(1436):[T:0.01]
|
var(1442):[G:0.03]
ACATATCTTT AATAAGATCT GTCATCTGAG ACCGGGGGC
C
ACCTCCCTGT
1500 |
var(1490):[T:0.08]
CTGGGTGCTG TTTCCCACGA GAC
A
GGGAGG AAACACAGGC AGGAGCCCCT
1550 |
var(1524):[G:0.09]
GGACACCAGC
G
TTC
A
CGCCT CCAAGGCTGA ATTTACTATG TCAGGAAGTT
1600 |
var(1561):[A:0.35]
|
var(1565):[G:0.05]
GCCCAACCCT GCCTGTATAG CCAGCAAGAA TTCTAATTAT AGCAAACAGA
1650
AACACTTGCA GAAAAAAAAA AAAATGAGAA CGGGAACATG ATAATTTTCA
1700
AAGAAAGAGT CTTTCTTTCA AGGAAA
G
T
C
A
G
G
T
T
C
A
T
G
G
T
T
A
C
G
A
A
G
C
T
G
1750 | Exon 1 |
UTR
C
T
G
A
C
C
C
C
A
G
G
A
T
C
C
C
A
G
C
C
C
G
T
G
G
G
A
G
A
G
A
A
G
G
G
G
G
T
C
T
C
T
G
A
C
A
G
C
C
C
1800
C
C
A
C
C
C
C
T
C
C
C
C
A
C
T
G
C
C
A
G
A
T
C
C
T
T
A
T
T
G
G
G
T
C
T
G
A
G
T
T
T
C
A
G
G
G
G
T
G
G
1850
G
G
C
C
C
C
A
G
C
T
G
G
A
G
G
T
T
A
T
A
A
A
A
C
A
G
C
T
C
A
A
T
C
G
G
G
G
A
G
T
A
C
A
A
C
C
T
T
C
G
1900 |
var(1884):[C:0.03]
G
T
T
T
C
T
C
T
T
C
G
G
G
G
A
A
A
G
C
T
G
C
T
T
T
C
A
G
C
G
C
A
C
A
C
G
G
G
A
A
G
A
T
A
T
C
A
G
A
A
1950
A
C
A
T
C
C
T
A
G
G
A
T
C
A
G
G
A
C
A
C
C
C
C
A
G
A
T
C
T
T
C
T
C
A
A
C
T
G
G
A
A
C
C
A
C
G
A
A
G
G
2000
C
T
G
T
T
T
C
T
T
C
C
A
C
A
C
A
G
C
A
C
T
T
T
G
A
T
C
T
C
C
A
T
T
T
A
A
G
GTA AGGTCCCC
C
C
2050 |
var(2005):[A:0.07]
|
var(2015):[T:0.01]
|
var(2018):[T:0.29]
|
var(2049):[T:0.25]
TCCAGGGTGG GATGAGGGAA AAAGAGGGCA GGCAGGGGAG GCGGTGGACT
2100
GTGGGTTCCC AAATCCAAGC TGGCAGACAC GGGGCATTGG CATGTAACAG
2150
GTTTCTGC
T
G
A
G
A
C
C
T
G
C
T
G
T
C
C
G
T
G
T
G
G
G
C
A
C
C
A
C
A
C
C
A
C
A
C
A
T
A
G
A
A
T
2200 |
REPEAT
G
A
C
C
C
G
G
T
A
C
C
A
G
A
G
A
A
G
T
A
T
G
T
T
T
G
C
G
A
T
C
T
C
A
T
T
C
A
C
C
C
T
T
T
T
G
T
A
A
G
2250
T
G
G
A
T
C
G
G
A
C
G
C
T
G
A
A
G
C
C
A
T
C
A
T
A
G
C
A
T
G
T
T
A
G
A
T
G
C
C
T
T
G
G
G
T
T
T
A
T
A
2300 |
var(2274):[C:0.01]
A
A
G
G
T
G
A
T
A
G
C
A
T
T
A
G
G
A
G
T
A
A
T
T
T
G
A
C
A
G
T
G
C
T
T
T
C
T
G
C
T
T
T
T
T
C
T
G
T
G
2350
T
G
C
T
T
G
C
T
A
G
A
A
A
A
T
G
T
A
C
A
C
A
C
C
T
A
C
A
C
A
T
G
G
C
T
A
G
A
G
T
T
C
T
C
T
G
T
T
T
A
2400
T
T
A
G
A
A
A
G
C
G
C
T
G
GTTCAGT TAGTCAATGA GCTCACGCCC AGGGCGAG
C
T
2450 |
var(2449):[T:0.02]
GACTGCCAGC CGGGGAGCCG CTTTTGGGGC TGGGACCCCA GCCTGCTTGT
2500
AGTGTTTCT
C
A
G
T
G
G
T
T
T
T
C
A
A
A
G
G
C
T
G
G
C
G
G
G
A
C
T
C
A
G
A
A
T
G
T
T
C
C
A
G
A
2550 |
REPEAT
T
G
G
C
T
G
G
T
G
A
A
A
C
C
T
C
A
G
G
T
CCC
T
C
C
T
A
G
C
A
G
C
T
T
T
A
T
T
C
A
C
A
G
T
A
G
C
C
A
2600 |
REPEAT
|
NOT SCANNED
A
G
A
G
G
T
G
G
A
G
A
C
A
G
C
C
C
T
C
G
T
A
C
C
C
A
T
C
T
A
T
A
G
A
T
G
A
A
T
G
G
A
A
A
A
A
T
A
T
A
2650
A
T
G
T
C
C
A
T
C
C
A
C
A
C
A
G
T
G
G
A
A
T
A
T
T
A
C
G
C
A
G
C
C
A
T
G
A
A
A
A
G
G
A
A
C
A
A
G
C
A
2700 |
REPEAT
G
C
T
T
T
A
T
T
C
A
C
A
A
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
G
A
C
A
G
C
C
C
T
C
A
T
A
C
C
C
A
T
C
T
A
T
2750
A
G
A
C
G
A
A
T
G
G
A
T
A
A
A
T
A
T
A
A
T
G
T
G
G
T
C
C
A
G
C
C
A
C
A
C
G
G
T
G
G
A
A
T
A
T
T
A
C
A
2800
C
A
G
C
C
A
T
G
A
A
A
A
G
G
A
A
C
A
A
G
C
A
G
C
T
T
T
A
T
T
C
A
C
A
A
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
2850 |
REPEAT
G
A
C
A
G
C
C
C
T
C
A
T
A
C
C
C
A
T
C
T
A
T
A
G
A
C
G
A
A
T
G
G
A
T
A
A
A
T
A
T
A
A
T
G
T
G
G
T
C
C
2900
A
G
C
C
A
C
A
C
A
G
T
G
G
A
A
T
A
T
T
A
C
A
C
A
G
C
C
A
T
G
A
A
A
A
G
G
A
A
C
A
A
G
C
A
G
C
T
T
T
A
2950 |
REPEAT
T
T
C
A
C
A
A
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
G
A
C
A
G
C
C
C
T
C
A
T
A
C
C
C
A
T
C
T
A
T
A
G
A
C
G
A
3000
A
T
G
G
A
T
A
A
A
T
A
T
A
A
T
G
T
G
G
T
C
C
A
G
C
C
A
C
A
C
A
G
T
G
G
A
A
T
A
T
T
A
C
A
C
A
G
C
C
A
3050
T
G
A
A
A
A
G
G
A
A
C
A
A
G
C
A
G
C
T
T
T
A
T
T
C
A
C
A
A
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
G
A
C
A
G
C
3100 |
REPEAT
C
C
T
C
A
T
A
C
C
C
A
T
C
T
A
T
A
G
A
C
G
A
A
T
G
G
A
T
A
A
A
T
A
T
A
A
T
G
T
G
G
T
C
C
A
G
C
C
A
C
3150
A
C
A
G
T
G
G
A
A
T
A
T
T
A
C
A
C
A
G
C
C
A
T
G
A
A
A
A
G
G
A
A
C
A
A
G
C
A
G
C
T
T
T
A
T
T
C
A
C
A
3200 |
REPEAT
A
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
G
A
C
A
G
C
C
C
T
C
A
T
A
C
C
C
A
T
C
T
A
T
A
G
A
T
G
A
A
T
G
G
A
G
3250
A
A
A
T
A
T
A
A
T
G
T
G
G
T
C
C
A
G
C
C
A
C
A
C
A
G
T
G
G
A
A
T
A
T
T
A
T
A
C
A
G
C
C
A
T
G
A
A
A
A
3300
G
G
A
A
C
A
A
G
C
A
G
C
T
T
T
A
T
T
C
A
C
A
A
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
G
A
C
A
G
C
C
C
T
C
G
T
3350 |
REPEAT
A
C
C
T
A
T
C
T
A
T
A
G
A
T
G
A
A
T
G
G
A
G
A
A
A
T
A
T
A
A
T
G
T
G
G
T
C
C
A
G
A
C
A
C
A
C
A
G
T
G
3400
G
A
A
T
A
T
T
A
T
A
C
A
G
C
C
A
T
G
A
A
A
A
G
G
A
A
C
A
A
G
C
A
G
C
T
T
T
A
T
T
C
A
C
A
A
T
A
G
C
C
3450 |
REPEAT
A
A
G
A
G
G
T
G
G
A
G
A
C
A
G
C
C
C
T
C
A
T
A
C
C
C
C
C
A
T
C
T
A
T
A
G
A
T
G
A
A
G
G
G
A
G
A
A
A
T
3500
A
T
A
A
T
G
T
C
C
A
T
C
C
A
C
A
C
A
G
T
G
G
A
A
T
A
T
T
A
C
A
C
A
G
C
C
A
T
G
A
A
A
A
G
G
A
A
C
A
A
3550 |
REPEAT
G
C
A
G
C
T
T
T
A
T
T
C
A
C
A
A
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
G
A
C
A
G
C
C
C
T
C
A
T
A
C
C
C
A
T
C
3600
T
A
T
A
G
A
T
G
A
A
T
G
G
A
A
A
A
A
T
A
T
A
A
T
G
T
C
C
A
T
C
C
A
C
A
C
A
G
T
G
G
A
A
T
A
T
T
A
C
A
3650
C
A
G
C
C
A
T
G
A
A
A
A
G
G
A
A
C
A
A
G
C
A
G
C
T
T
T
A
T
T
C
A
C
A
A
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
3700 |
REPEAT
G
A
C
A
G
C
C
C
T
C
A
T
A
C
C
C
C
A
T
C
T
A
T
A
G
A
T
G
A
A
T
G
G
A
G
A
A
A
T
A
T
A
A
T
G
T
G
G
T
C
3750
C
A
G
C
C
A
C
A
C
G
G
T
G
G
A
A
T
A
T
T
A
C
A
C
A
G
C
C
A
T
G
A
A
A
A
G
G
A
A
T
A
A
G
C
A
G
C
T
T
T
3800 |
REPEAT
A
T
T
C
A
C
A
C
T
A
G
C
C
A
A
G
A
G
G
T
G
G
A
G
A
G
A
G
T
C
C
T
C
A
T
A
C
C
C
A
T
C
T
A
T
A
G
A
T
G
3850
A
A
T
G
G
A
G
A
A
A
T
A
T
A
A
T
G
T
G
G
T
C
C
A
G
C
C
A
C
A
C
G
G
T
G
G
A
A
T
A
T
T
A
C
A
C
A
G
C
C
3900
A
T
G
A
A
A
A
G
G
A
A
C
G
A
G
G
C
T
C
T
G
C
C
A
C
A
G
G
T
G
G
C
A
A
T
G
T
G
G
G
T
G
A
A
T
G
C
T
G
A
3950 |
NOT SCANNED
G
G
A
C
A
T
C
A
T
G
C
T
T
C
C
T
G
A
G
A
G
A
G
G
C
C
A
G
A
T
A
C
A
A
A
A
A
G
A
T
A
C
A
T
A
G
T
G
T
C
4000
T
G
T
A
T
G
A
T
T
C
C
A
T
T
T
A
T
T
C
C
C
T
A
T
G
T
C
C
A
G
A
T
A
C
A
G
G
C
A
A
A
T
C
C
A
C
A
G
A
G
4050
A
C
A
G
A
A
A
G
T
G
G
A
T
G
A
G
T
G
G
T
T
G
C
C
A
C
A
G
G
C
T
G
G
G
G
A
A
G
A
G
G
A
A
G
G
A
C
G
G
G
4100
T
C
T
T
T
A
A
T
G
G
G
T
C
T
G
G
A
G
T
C
T
C
C
T
T
T
T
G
G
G
G
T
C
G
T
G
A
C
A
A
T
G
T
T
C
T
A
G
A
A
4150
G
A
T
A
G
A
A
G
T
G
G
T
G
G
T
T
T
T
T
T
T
T
G
A
G
A
C
A
G
A
G
T
C
T
C
G
C
T
C
T
G
T
C
G
C
C
C
A
G
G
4200 |
REPEAT
C
T
G
G
A
G
T
G
C
A
G
T
G
G
C
G
C
G
A
T
C
T
C
A
G
C
T
C
A
C
T
G
C
A
A
C
C
T
C
C
A
C
C
T
C
C
C
G
G
G
4250
T
T
C
A
A
G
C
A
A
T
T
C
T
C
C
T
G
C
C
T
C
A
G
C
C
T
C
C
T
G
A
G
T
A
G
C
T
G
G
G
A
C
T
A
C
A
G
G
C
A
4300 |
NOT SCANNED
C
C
C
G
C
A
A
C
T
A
C
G
C
C
T
G
G
C
T
A
A
T
T
T
T
T
G
T
A
T
G
T
T
T
A
G
T
A
G
A
G
A
C
T
T
T
G
T
A
T
4350
G
T
T
T
A
G
T
A
G
A
G
T
A
G
T
A
G
A
G
A
T
T
T
T
G
T
A
T
G
T
T
T
A
G
T
A
T
G
T
T
T
T
G
T
A
T
G
T
T
G
4400
G
T
C
A
G
G
C
T
G
G
T
C
T
C
G
A
A
C
T
C
C
T
G
A
C
C
T
C
A
A
G
C
A
A
T
C
C
A
C
C
C
C
C
C
T
C
A
G
C
C
4450
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
T
A
C
A
G
G
C
G
T
G
A
G
C
C
A
C
C
G
C
G
C
C
T
G
G
C
C
A
A
T
G
A
A
4500
A
A
T
A
T
T
A
A
T
C
A
A
T
A
A
A
T
G
T
T
A
A
G
A
G
C
A
C
A
G
A
T
T
T
C
C
C
A
A
C
GTTCTGACTC
4550
AGGCATCTTC CTGGACCACA GCCCCTACAG GCAAGTGTGA CTGTGTGTGG
4600
TGAGCCCATG AGCTGAACAC AGGCTCTGTC CGAAAGGAGA CTCTAGAGAT
4650
TGCCTGTTGC CTTGGAGGTG GGCTGCGGTC CCTCTGCCCA GGCAGGAAGG
4700
GGCTCCGAGG CCTCTGGAAC CTCATTT
T
AC CTTTTCCCTG CTGCCCTCAG
4750 |
var(4728):[C:0.20]
TCCCGTCCCC AGCCTCAAGG GGCTCAGCTT TTTCCAG
G
CT CACC
C
C
T
T
C
C
4800 |
var(4788):[A:0.10]
|
NOT SCANNED
A
T
T
T
A
T
A
A
T
T
T
G
G
A
G
A
C
A
A
G
C
A
A
G
G
T
C
C
A
C
T
G
A
C
G
C
T
A
A
C
G
C
C
A
T
T
T
G
G
T
4850
T
C
T
T
T
A
A
A
A
G
A
T
G
T
T
A
G
G
C
C
G
G
G
C
G
C
G
G
T
G
G
C
T
C
A
C
G
C
C
T
G
T
C
A
T
C
C
C
A
G
4900 |
REPEAT
C
A
C
T
T
T
G
G
G
A
G
G
C
C
A
A
G
G
C
G
G
G
T
G
G
A
T
C
A
T
G
A
G
G
T
C
A
G
G
A
G
T
T
C
G
A
G
A
C
C
4950
A
G
C
C
T
G
A
C
C
A
A
C
A
T
G
G
T
G
A
A
A
C
A
C
C
A
T
C
T
C
T
A
C
T
A
A
A
A
A
T
A
G
A
A
A
A
A
T
T
A
5000
G
C
T
G
G
G
T
G
T
G
G
T
G
G
C
G
G
A
C
A
C
C
G
G
T
A
A
T
C
C
C
A
T
C
T
A
C
T
G
G
G
G
A
G
G
C
T
G
A
G
5050
G
C
A
G
G
A
G
A
A
T
C
G
C
T
T
G
A
A
C
G
T
G
G
G
A
G
G
T
G
G
A
G
G
T
T
G
C
A
G
T
G
A
A
C
C
A
A
G
A
T
5100
C
G
T
G
C
C
A
C
T
G
C
A
C
T
C
C
G
G
C
C
T
G
G
A
C
A
A
C
A
A
G
A
G
T
G
A
G
A
C
T
C
C
A
T
C
T
C
A
G
A
5150
A
A
A
A
A
C
A
A
A
A
C
A
A
A
A
C
A
A
A
A
C
A
A
A
A
A
A
C
C
A
G
A
A
A
A
G
A
C
A
G
C
T
G
C
C
A
C
C
C
C
5200
A
G
A
G
C
A
C
A
G
T
G
T
A
G
G
A
G
A
G
C
C
A
G
C
C
T
T
T
C
T
G
G
G
A
T
G
C
G
G
C
A
G
A
A
A
G
T
T
C
C
5250
A
G
T
G
C
A
G
G
A
G
G
C
T
G
A
G
G
T
C
C
T
G
T
A
C
C
C
C
C
T
T
G
T
T
A
C
G
G
T
A
A
C
T
G
C
A
G
C
C
A
5300
C
T
T
A
G
G
A
A
T
T
T
C
C
G
T
G
T
G
T
T
G
A
T
T
T
C
A
T
C
A
T
T
G
T
A
A
T
T
A
T
A
C
T
T
C
C
T
T
C
C
5350
A
C
T
G
C
T
T
T
G
T
C
A
T
C
T
G
A
G
C
T
T
C
C
T
G
G
T
G
T
G
C
C
G
C
A
G
A
G
G
A
T
G
T
G
T
T
T
T
C
C
5400
T
G
G
T
T
T
G
T
G
G
A
T
A
C
A
G
C
T
T
G
A
G
C
C
A
A
G
A
A
C
G
G
G
C
T
A
A
A
C
C
C
C
C
A
G
G
G
C
A
G
5450
C
A
A
C
T
G
C
A
A
G
C
T
C
C
A
C
C
T
C
C
C
G
G
G
T
T
C
A
A
C
T
G
A
T
T
G
T
C
C
T
G
C
C
T
C
A
G
C
C
T
5500 |
REPEAT
C
C
C
G
A
G
T
A
G
C
T
G
G
G
A
T
T
A
T
A
G
G
C
A
C
A
C
T
C
C
A
C
C
A
C
G
C
C
T
G
G
C
T
A
A
T
T
T
T
T
5550
G
T
A
T
T
T
T
T
A
G
T
A
G
A
G
A
C
G
G
G
G
T
T
T
C
A
C
C
A
T
G
T
T
A
G
C
C
A
G
G
C
T
G
G
T
C
T
T
G
A
5600
A
C
T
C
C
T
G
A
C
C
T
C
G
G
G
C
A
A
T
C
T
G
C
C
C
A
C
C
T
C
T
G
C
T
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
5650
T
T
A
C
T
G
G
C
A
T
G
A
G
C
C
A
C
T
G
C
A
C
C
C
A
G
C
C
GG CAGGGCTTCT TTCAAAAGGG
5700
AACGGCTGAC ACACACACAG ATGCATGCAC ATACATGCAC ACATAC
A
C
A
C
5750 |
NOT SCANNED
T
G
A
T
G
C
A
A
A
C
A
C
A
T
T
T
G
T
A
C
A
C
A
T
A
C
A
T
T
C
A
C
A
C
A
T
G
C
A
T
G
C
A
C
A
T
A
A
A
T
5800
A
T
G
C
A
C
T
T
C
T
A
G
G
C
A
C
A
T
G
C
A
T
G
C
A
C
A
C
A
T
A
C
A
G
A
C
T
C
A
T
G
C
A
T
G
T
A
T
A
T
5850
T
T
G
T
G
T
A
T
G
C
A
C
A
T
A
T
A
T
T
T
A
T
G
C
A
C
A
T
G
T
G
T
G
T
A
C
A
C
G
T
G
G
A
A
T
G
C
A
T
G
5900
C
A
C
A
G
A
T
A
C
A
T
A
T
G
C
A
T
T
C
A
A
A
C
A
C
A
A
A
G
A
C
T
G
T
G
T
G
T
A
C
C
T
G
C
A
T
G
C
A
T
5950
G
A
A
A
A
C
A
C
A
C
A
A
A
C
A
C
A
G
C
T
G
G
G
C
A
C
G
G
T
G
G
C
T
C
A
C
A
C
C
T
G
T
A
A
T
C
T
C
A
G
6000 |
REPEAT
C
A
C
T
T
G
G
C
G
A
G
G
A
A
A
A
G
G
C
G
G
G
C
G
G
A
T
C
A
C
C
T
G
A
G
G
C
A
G
G
A
G
T
C
C
G
A
G
A
C
6050
C
A
G
C
C
T
G
G
C
C
A
A
C
A
T
G
G
T
C
A
A
A
T
C
T
C
T
A
C
T
A
A
A
A
A
A
T
A
C
A
A
A
A
A
G
T
G
G
G
C
6100 |
REPEAT
T
G
G
A
T
G
C
G
G
T
G
G
C
T
G
A
C
G
C
C
T
G
T
C
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
T
G
A
G
G
T
6150
G
G
G
T
G
G
A
T
C
A
C
C
T
G
A
G
G
T
C
A
G
G
A
G
T
T
C
G
A
G
A
C
C
A
G
C
C
T
G
G
C
C
A
A
C
A
C
G
G
T
6200
G
A
A
A
C
C
C
C
G
T
C
T
C
T
G
C
T
A
A
A
A
A
T
A
C
A
A
A
A
A
T
T
A
G
C
C
G
G
A
C
A
T
G
G
T
G
G
T
G
G
6250
G
T
G
C
C
T
A
T
A
A
T
C
C
C
A
G
C
T
A
C
T
C
G
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
C
A
A
T
C
G
G
T
T
G
A
6300
A
C
C
T
G
G
G
A
G
G
C
G
G
A
G
G
T
T
G
C
A
G
T
G
A
G
C
C
C
A
G
A
T
C
A
C
G
C
C
A
T
T
G
C
A
C
T
C
C
A
6350
G
C
C
T
G
G
G
C
A
A
C
A
A
G
A
G
C
A
A
A
A
C
T
C
T
G
T
C
T
C
A
A
A
A
A
A
T
A
A
A
T
A
A
A
T
A
A
A
T
A
6400
A
A
T
A
A
T
A
C
A
A
A
A
A
T
T
A
G
C
C
A
G
G
C
A
T
G
G
T
G
G
C
G
A
G
T
G
C
C
T
G
T
A
A
T
C
C
C
A
G
C
6450 |
REPEAT
T
A
C
T
C
A
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
G
T
C
A
C
T
T
G
A
A
C
C
T
G
G
G
A
G
G
C
A
G
A
G
G
T
6500
T
G
C
A
A
T
G
A
G
C
C
A
A
G
A
T
C
G
T
G
C
C
A
C
T
G
C
A
C
T
C
T
A
G
C
C
T
G
G
A
C
G
A
C
A
A
G
G
G
C
6550
G
A
G
T
C
T
C
C
A
T
C
A
G
G
A
A
A
A
A
A
A
A
A
A
A
A
G
A
A
A
A
C
A
C
A
C
A
A
A
C ACTTATGTGT
6600
GCACACAGAT ACACACGGGC ACAAAAATGT ACACACATGT GCAAGCACAC
6650
ACACACAGAC ACATGTACAC AGTACCCGTG TGTGCACAGG CATGCATGCA
6700
GTCCTGCAAA TGTGCA
A
A
C
A
GACATGGCTA CATAGAGGCA TGCACACATA
6750 |
var(6717):[:0.08]
TAGACCCATG TACACACACA CGAATATTCG TGCACACATG T
A
G
AAGCACA
6800 |
var(6792):[G:0.01]
|
var(6793):[C:0.01]
CTCTGACTTC TACATG
C
GCA AAGGCGCA
T
T TGCACACAGA CA
C
ATATGCA
6850 |
var(6817):[T:0.14]
|
var(6829):[G:0.04]
|
var(6843):[T:0.02]
CACTCACCAC C
A
CTTTCCCT CCAGAAGCAG CTCCTTCTGC TGTGAGCACC
6900 |
var(6862):[G:0.35]
AGGCTCTGGA AGGGGCAAGC
G
TCCTTCATT ACCC
G
CAACC CAGTTTCACA
6950 |
var(6921):[A:0.09]
|
var(6935):[A:0.03]
GCCAGTCCCC GCTGCCTGAC TCTCGTTTCT CCT
C
CAG
C
A
G
G
C
A
C
C
T
C
T
G
T
7000 |
var(6984):[G:0.09]
| Exon 2 |
UTR
C
C
T
G
C
G
T
T
C
C
G
G
A
G
C
T
G
C
G
T
T
C
C
C
G
A
T
G
G
T
C
C
T
C
C
T
T
T
G
G
C
T
C
A
C
G
C
T
G
C
7050 |
var(7024):[T:0.01]
M V L L W L T L 8
T
C
C
T
G
A
T
C
G
C
C
C
T
G
C
C
C
T
G
T
C
T
C
C
T
G
C
A
A
A
C
G
A
A
G
G
A
A
G
G TAAGAACTGG
7100 |
var(7059):[A:0.01]
L L I A L P C L L Q T K E 21
AGAAAA
G
ATG CACGTGCCAC CTGGGGAGCG GTGGGGGTAG ACAGACACAC
7150 |
var(7107):[A:0.21]
AATGTCAGCG TGCCGTCCTT CAGGG
A
A
A
C
T
T
T
T
C
A
T
G
C
T
G
A
G
C
T
T
A
T
G
G
C
7200 |
REPEAT
|
var(7195):[C:0.12]
A
G
A
G
T
C
T
C
A
T
G
C
A
G
T
G
G
T
C
G
G
G
A
A
T
G
A
C
T
C
A
G
A
C
A
C
T
T
C
C
C
T
G
T
A
C
C
C
G
T
7250 |
NOT SCANNED
C
A
C
C
A
A
G
T
T
C
C
C
T
G
T
A
A
T
G
C
A
G
C
A
T
C
T
T
G
C
A
A
A
A
T
G
G
T
A
A
T
A
C
G
A
C
C
T
C
A
7300
C
A
G
G
C
A
G
G
G
A
C
C
T
G
A
T
C
G
T
G
A
C
A
C
A
G
A
T
G
C
C
A
T
G
T
G
A
G
G
T
G
T
T
T
T
G
A
T
G
A
7350
A
A
C
T
C
A
C
A
T
G
C
T
G
G
G
A
T
C
A
A
C
A
G
C
A
C
C
A
A
T
A
A
C
A
A
T
T
T
C
C
A
G
TTTCCTTC
7400
ATTGTTTATC TTAC
T
T
T
T
T
C
A
T
T
T
T
G
T
T
A
T
T
A
T
T
T
T
T
A
T
T
T
T
G
G
A
G
A
C
A
G
7450 |
REPEAT
|
var(7426):[C:0.15]
A
G
T
C
T
T
A
C
T
G
T
C
T
T
G
C
C
C
A
G
G
C
T
G
G
A
G
T
G
C
A
A
T
A
G
T
G
T
G
A
T
C
T
C
G
G
C
T
C
A
7500 |
var(7451):[G:0.15]
|
var(7457):[G:0.01]
|
var(7458):[T:0.04]
|
var(7459):[C:0.05]
C
T
G
C
A
A
C
C
T
C
T
G
C
C
T
C
C
C
G
G
A
T
T
C
A
A
G
C
G
A
T
T
C
T
T
C
T
G
C
C
T
C
A
G
C
C
T
C
C
C
7550
G
A
G
G
A
G
C
T
G
A
G
A
T
T
A
C
A
G
T
C
G
C
G
C
A
C
C
A
C
C
A
T
G
C
C
C
G
G
C
T
A
A
T
T
T
C
T
G
T
A
7600 |
var(7583):[A:0.11]
T
T
T
T
T
G
A
T
A
G
A
G
A
C
G
G
G
A
T
T
T
C
A
C
T
A
T
G
T
C
G
G
T
C
A
G
G
C
T
G
G
T
C
T
A
G
A
A
C
T
7650
G
C
T
G
A
C
C
A
C
A
A
G
T
G
A
T
C
C
G
T
C
T
G
C
C
T
T
G
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
T
A
7700
C
A
G
G
T
G
T
G
A
G
C
C
A
C
A
G
C
G
C
C
C
G
G
C
C
TTTTT T
T
TCATTGGT TTTTACAGTC
7750 |
var(7732):[C:0.02]
TATTACTGCA GGGTTTCACT TTACCTTGAA TTTCTTTTAA CTTTAATTTG
7800
CTTTTCATTC TTTAAC
T
T
C
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
T
G
A
C
A
C
A
G
A
G
T
T
T
C
7850 |
REPEAT
|
NOT SCANNED
A
T
T
C
T
G
G
T
C
G
C
C
C
A
G
G
C
T
G
G
A
G
T
G
T
A
A
T
A
G
C
G
T
G
A
C
C
A
T
G
G
C
T
C
A
C
T
G
C
A
7900
A
C
C
T
C
T
A
C
C
T
G
C
T
G
G
G
T
T
C
A
A
T
T
G
A
T
T
C
T
C
C
T
G
T
C
T
C
A
G
C
C
T
C
C
C
A
A
G
C
A
7950
C
C
T
G
G
G
A
T
T
A
C
A
G
G
T
G
T
C
C
G
C
C
A
C
C
A
C
G
C
C
C
A
G
C
T
A
A
T
T
T
T
T
C
T
G
T
T
T
T
T
8000
A
C
T
A
G
A
G
A
C
G
G
G
G
T
T
T
C
A
C
C
G
T
G
T
T
A
G
A
C
A
G
G
A
T
G
G
T
C
T
C
G
A
T
C
T
C
C
T
G
A
8050
C
C
T
C
A
T
G
A
T
C
C
G
C
C
T
G
C
C
T
C
G
G
GGTTGGGA TTACA
C
A
C
T
T
T
G
G
G
A
G
G
C
C
A
8100 |
REPEAT
A
G
G
C
A
G
G
T
G
G
A
C
G
A
T
C
A
C
A
A
G
G
T
C
A
G
G
A
G
T
T
C
G
T
G
A
C
C
A
G
C
C
T
G
A
C
T
A
A
C
8150
A
C
A
G
T
G
A
A
A
C
C
C
C
G
T
C
T
C
T
A
C
T
A
A
A
A
A
T
A
C
A
A
A
A
A
T
C
A
G
C
T
G
G
G
C
G
T
G
G
T
8200 |
var(8153):[G:0.10]
G
G
C
G
G
G
C
G
C
C
T
G
T
A
A
T
C
C
C
A
G
T
T
A
C
T
C
G
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
G
T
C
G
8250 |
var(8204):[A:0.33]
|
var(8228):[A:0.01]
|
var(8245):[T:0.02]
|
var(8250):[A:0.01]
C
T
T
G
A
A
C
C
C
G
G
G
A
G
G
A
G
G
A
G
G
T
T
G
C
A
G
T
G
A
G
C
C
T
A
G
A
T
C
A
C
G
C
C
A
T
T
G
C
A
8300 |
var(8266):[T:0.01]
|
var(8276):[G:0.01]
|
var(8281):[A:0.01]
|
var(8284):[G:0.04]
|
var(8291):[T:0.01]
|
var(8296):[C:0.02]
C
T
C
C
A
G
C
C
T
G
G
G
C
G
A
C
A
G
A
G
T
G
A
G
A
C
T
C
C
G
T
C
T
C
A
A
AATG AATGAATGAA
8350 |
var(8314):[C:0.01]
|
var(8318):[T:0.02]
TGAAT
G
AATT TCTTATAAGA ATTTTTTTCC CCAGACAGTT TGTTTTAAGG
8400 |
var(8356):[A:0.03]
GATAAATTAT CCTTC
T
A
A
G
T
T
A
G
A
A
G
A
A
A
A
T
A
A
T
G
C
C
A
G
A
A
G
T
C
T
A
G
A
C
A
8450 |
NOT SCANNED
T
T
C
T
T
A
T
G
C
T
T
T
G
G
T
C
C
C
G
C
T
T
A
T
C
A
A
A
C
C
A
A
G
G
T
T
G
C
T
G
A
C
C
T
T
G
A
T
A
A
8500
C
C
A
C
T
C
A
A
G
A
T
C
C
T
T
A
C
A
G
T
T
T
A
T
A
A
A
G
T
C
A
T
T
T
C
C
T
C
A
A
G
T
T
T
T
C
T
A
A
G
8550
T
G
G
C
C
G
A
T
C
A
G
A
G
A
T
A
A
A
C
C
C
T
A
G
A
G
A
A
A
T
A
G
T
T
G
A
T
G
T
A
T
G
T
T
T
C
T
A
G
C
8600
T
T
T
G
G
G
T
G
A
C
C
A
G
C
A
A
A
A
T
G
T
G
A
T
A
G
A
A
T
A
T
T
G
C
C
T
T
T
T
A
C
T
G
G
C
C
G
G
G
T
8650 |
REPEAT
G
C
A
A
C
G
G
C
T
C
A
C
G
T
C
T
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
T
G
A
G
G
C
G
G
G
T
G
8700
G
A
T
C
A
C
T
T
G
A
G
G
T
C
A
G
G
A
G
T
T
C
A
A
A
A
C
C
A
G
C
T
T
G
G
C
C
A
T
C
A
T
G
G
T
G
A
A
A
C
8750
C
C
C
G
T
C
T
G
T
A
C
T
A
A
A
A
A
T
A
C
A
A
A
A
A
A
T
T
A
G
C
T
G
G
G
C
G
C
G
G
T
G
C
T
G
T
G
C
A
C
8800
C
T
G
T
A
A
T
C
C
C
T
G
C
T
A
C
T
C
A
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
A
T
C
A
C
T
T
G
A
A
C
C
C
8850
G
G
G
A
G
G
C
G
G
A
G
G
T
T
G
C
C
G
T
G
A
G
C
C
A
A
G
A
T
C
A
C
G
C
C
A
T
T
G
C
A
C
T
C
C
A
A
C
C
T
8900
G
G
G
T
G
A
C
A
G
A
G
C
G
A
G
G
C
T
C
C
A
T
C
T
C
A
A
A
A
A
A
A
A
A
A
A
A
A
A
A
A
A
A
A
A
G
A
A
T
A
8950
T
T
G
C
C
T
T
T
A
A
C
A
T
C
T
T
T
G
T
A
C
A
G
G
T
C
A
T
T
T
A
T
G
A
A
A
T
A
T
C
T
T
G
A
G
C
T
C
T
G
9000
T
G
A
T
G
G
C
T
A
A
G
A
G
A
G
A
C
C
T
T
C
T
T
T
T
T
C
T
T
T
C
T
T
T
C
T
T
T
T
T
T
T
T
T
T
T
T
T
G
A
9050 |
REPEAT
G
A
C
G
G
A
G
T
T
T
T
T
T
T
G
T
T
T
T
T
T
T
G
A
G
A
T
G
G
A
G
T
C
T
C
G
C
T
C
T
G
T
T
A
C
C
C
A
G
G
9100
C
T
G
G
A
G
T
G
C
A
G
T
G
G
C
G
C
G
A
T
C
T
C
A
G
C
T
C
A
C
C
G
C
A
A
C
C
T
C
C
G
C
C
T
C
C
C
G
A
G
9150
T
T
C
C
A
G
T
G
A
T
T
C
T
C
C
T
G
C
C
T
C
A
G
C
T
T
C
C
T
G
A
T
T
A
G
C
T
G
G
G
A
T
T
A
C
A
G
G
C
G
9200
C
C
C
G
C
C
A
C
C
A
C
G
C
C
C
A
A
C
T
A
A
T
T
T
T
T
G
T
A
T
T
T
T
T
A
G
T
C
G
C
G
A
C
G
G
G
G
T
T
T
9250
C
A
C
C
G
T
G
T
T
A
G
C
C
A
G
G
A
T
G
G
T
C
T
T
G
A
T
C
A
C
T
T
G
A
C
C
T
G
G
T
G
A
T
C
C
G
C
C
C
A
9300
C
C
T
T
G
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
G
A
C
G
G
G
C
G
T
G
A
G
C
C
A
C
C
A
C
G
C
C
C
G
T
9350
T
T
G
C
T
T
T
A
T
G
A
C
T
T
C
T
A
C
C
A
G
C
T
C
A
C
A
G
A
A
G
T
C
T
C
C
T
G
T
C
T
A
C
A
T
A
G
A
A
C
9400
T
C
C
A
C
T
T
C
C
C
A
G
C
C
A
G
G
C
T
C
A
G
T
A
A
C
T
C
A
C
G
T
C
T
G
T
G
A
T
C
C
C
A
G
C
A
C
T
T
T
9450 |
REPEAT
G
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
C
A
G
A
T
C
A
T
G
T
G
A
G
G
T
T
G
G
G
A
G
T
T
C
G
A
G
A
C
C
A
G
C
C
9500 |
var(9464):[G:0.09]
T
G
G
C
C
A
A
C
A
T
G
G
T
G
A
A
A
C
C
C
C
A
T
C
T
C
T
A
G
T
A
A
A
A
A
T
A
C
A
A
A
A
A
T
T
A
G
C
C
G
9550
A
G
T
G
T
G
G
T
G
G
C
A
G
G
C
A
C
C
T
G
T
T
A
T
C
C
C
A
G
C
T
G
C
A
C
A
G
C
A
G
G
C
T
G
A
C
A
C
A
G
9600
G
A
T
A
A
T
C
G
C
T
T
G
A
A
C
C
C
G
G
G
A
G
G
C
G
G
A
G
G
T
T
G
T
A
G
T
G
A
G
C
C
G
A
G
A
T
C
G
C
G
9650
C
C
A
C
T
G
A
A
T
T
C
C
A
G
C
C
T
G
G
G
C
G
A
C
A
G
A
G
T
G
A
G
A
C
T
C
C
G
T
C
T
C
A
A
A
A
C
A
A
A
9700
C
A
A
G
C
A
A
A
C
A
A
A
A
A
T
A
C
C
C
A
T
T
A
C
A
A
T
G
T
T
G
T
T
T
T
A
A
G
A
T
T
G
T
T
G
T
A
T
A
T
9750 |
NOT SCANNED
C
A
A
C
T
G
G
G
C
A
T
G
G
T
G
G
C
T
C
A
T
G
C
T
T
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
A
G
A
G
G
C
C
G
9800 |
REPEAT
A
G
G
C
G
G
A
C
A
G
A
T
C
A
C
G
A
G
G
T
C
A
G
G
A
G
A
T
C
G
A
G
A
C
C
A
T
C
C
T
G
G
C
C
A
A
C
A
T
G
9850
G
T
G
A
A
A
C
C
C
C
A
T
C
T
C
T
A
G
T
A
A
A
A
A
T
A
C
A
A
A
A
A
T
T
A
G
C
C
G
G
G
C
G
T
G
G
T
G
G
T
9900
G
G
G
C
T
C
C
T
G
T
A
A
T
C
C
T
A
G
C
T
A
C
T
C
G
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
A
T
C
G
C
T
T
9950
G
A
A
C
C
C
G
G
G
A
G
G
T
A
G
A
G
G
T
T
G
C
G
G
T
G
A
G
C
T
G
A
G
A
T
C
G
T
G
C
C
A
C
T
G
C
A
C
T
C
10000
C
A
G
C
C
T
G
G
G
T
G
A
C
A
A
G
A
G
C
A
A
A
A
C
T
C
C
G
T
C
T
C
A
A
A
A
A
A
A
T
A
A
A
A
A
A
T
T
T
A
10050
A
A
A
A
A
A
T
A
A
A
G
A
A
C
T
C
G
A
C
C
T
C
C
C
A
A
A
G
G
T
A
T
T
G
G
C
T
A
A
C
T
C
C
A
C
G
G
G
C
A
10100
A
A
A
A
A
A
C
C
A
T
A
C
C
C
A
T
T
A
C
A
A
T
G
C
T
G
T
T
T
T
A
A
G
A
T
T
G
T
T
G
A
C
C
T
G
G
T
G
C
G
10150 |
REPEAT
G
T
G
G
C
T
C
A
T
G
C
C
T
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
T
G
A
G
G
C
G
G
A
C
G
A
A
T
10200
C
A
T
G
A
G
G
T
C
A
G
G
A
G
A
T
C
G
A
G
A
C
C
A
T
C
C
T
G
G
C
T
A
A
C
A
C
G
G
T
G
A
A
A
C
G
C
C
A
T
10250
C
T
C
T
A
C
T
A
A
A
A
A
T
A
C
A
A
A
A
A
A
A
A
A
A
A
A
A
T
T
A
G
C
C
G
G
G
C
G
T
G
G
T
G
G
C
G
G
G
C
10300
G
C
C
T
G
T
A
G
T
C
C
C
A
G
C
T
A
C
T
C
G
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
G
T
T
G
C
T
T
G
A
A
C
10350
C
A
G
G
A
G
G
C
G
G
A
G
C
T
T
G
C
A
G
T
G
A
G
C
T
G
A
G
A
T
C
G
T
G
C
C
A
C
T
G
T
A
G
T
C
C
A
G
C
C
10400
A
G
G
G
C
G
A
C
A
A
G
A
G
T
G
A
A
A
C
T
C
C
A
T
G
T
C
A
A
A
A
A
A
T
T
T
A
A
A
A
A
A
A
T
T
A
A
A
T
A
10450
A
A
A
G
A
A
C
T
C
C
A
C
C
T
C
C
C
A
A
A
G
G
T
A
T
T
G
G
C
T
A
A
C
T
C
C
A
C
G
G GCAAAAAAAA
10500
AAAACCATAC CCCTTACAAT GCCGTTTTAA GATTCTTACG TATCTCTTC
T
10550 |
var(10550):[G:0.31]
AACTCCAACC TGTCACCGTT TTAG
A
T
C
C
A
A
A
C
C
C
A
C
C
A
A
T
C
A
C
G
A
A
C
C
T
A
10600 | Exon 3
D P N P P I T N L 30
A
G
G
A
T
G
A
A
A
G
C
A
A
A
G
G
C
T
C
A
G
C
A
G
T
T
G
A
C
C
T
G
G
G
A
C
C
T
T
A
A
C
A
G
A
A
A
T
G
T
10650
R M K A K A Q Q L T W D L N R N V 47
G
A
C
C
G
A
T
A
T
C
G
A
G
T
G
T
G
T
T
A
A
A
G
A
C
G
C
C
G
A
C
T
A
T
T
C
T
A
T
G
C
C
G
GTAAATC
10700
T D I E C V K D A D Y S M P 61
ATACTCTCTA TTGTTTTTTT ATTTTTATTT T
A
TTTA
T
T
T
A
T
G
T
A
T
T
T
A
T
G
10750 |
var(10732):[G:0.06]
|
REPEAT
T
A
T
T
T
A
T
T
T
A
T
T
T
T
T
T
G
A
G
A
C
G
G
A
G
T
C
T
T
G
C
T
C
T
G
T
C
G
C
C
C
A
G
G
C
T
G
G
A
C
10800 |
var(10796):[C:0.02]
T
G
C
G
G
T
G
A
C
C
C
G
A
T
C
T
C
C
G
C
T
C
T
C
T
G
C
A
A
C
C
T
C
C
A
C
C
T
C
C
C
A
G
G
T
C
C
A
T
G
10850
C
C
A
T
T
C
T
C
C
T
G
C
C
T
C
A
A
C
C
T
C
C
C
G
A
G
T
A
G
C
T
G
G
G
A
C
T
A
C
A
G
G
C
G
C
C
C
G
C
C
10900 |
var(10886):[T:0.20]
A
C
C
A
T
G
C
C
C
G
G
C
T
A
A
T
T
T
T
T
T
T
G
T
A
T
T
T
T
T
A
G
T
A
G
A
G
A
T
G
G
G
G
T
T
T
C
A
C
T
10950 |
NOT SCANNED
G
T
G
T
T
A
G
C
C
A
G
G
A
G
G
G
T
C
T
C
G
A
T
C
T
C
C
T
G
A
C
C
T
C
G
T
G
A
T
C
T
G
C
C
C
G
C
C
T
C
11000
G
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
T
A
C
A
G
G
C
G
C
G
A
G
T
C
A
C
C
G
C
G
C
A
T
G
G
C
C
C
A
11050
G
A
C
T
C
T
C
T
A
A
T
G
T
T
G
A
C
G
A
A
C
A
A
G
A
C
G
T
T
T
C
C
G
T
C
T
T
C
T
G
C
A
G
G
A
A
T
C
T
C
11100
A
G
A
A
C
C
AATA CTGCTCCCAT CGCTGGTGTC ATGACTACCT GGTTTCTGCC
11150
CCGAAGTCAG GTGTGGGATT TGAA
G
TGACT TTGGAG
G
GTC TGGTTCCCCG
11200 |
var(11175):[C:0.01]
|
var(11187):[C:0.27]
TCCGCGGGAC ATCTAAGATG GCACACACTG GACAGGGTGG ATGTGAAAGT
11250
GAAATGAGGC TAAGCTATGA CTGGTG
C
GAA ACCCAACCCC AC
G
C
T
G
G
G
C
G
11300 |
var(11277):[T:0.02]
|
REPEAT
T
G
G
T
G
G
C
T
C
A
C
G
T
C
T
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
T
G
A
G
G
C
G
G
G
C
G
G
11350 |
var(11345):[A:0.01]
|
var(11349):[A:0.01]
A
T
C
A
T
G
A
G
G
T
C
A
G
G
A
G
T
T
C
G
A
G
A
C
C
A
G
T
C
T
G
G
C
C
A
A
C
A
C
G
G
T
G
A
A
A
C
G
C
T
11400 |
var(11397):[T:0.04]
G
T
C
T
C
T
G
C
T
A
A
A
A
A
T
A
C
G
A
A
A
G
T
T
A
G
C
C
G
G
G
C
A
C
A
G
T
G
G
C
T
C
A
C
A
C
C
A
G
C
11450 |
REPEAT
A
C
T
T
T
G
A
G
A
G
G
C
T
G
A
G
G
C
G
G
A
T
G
G
A
T
C
A
C
C
T
G
G
G
G
C
C
A
G
G
A
G
T
T
C
G
A
G
A
C
11500 |
var(11469):[A:0.08]
|
var(11488):[C:0.01]
T
A
G
T
C
T
G
G
G
C
A
A
C
A
T
G
G
T
G
A
A
A
C
C
C
C
G
C
C
T
C
C
A
C
T
A
A
A
A
A
T
A
T
A
A
A
A
A
T
T
11550
A
G
C
T
G
G
G
C
A
T
G
G
T
G
G
T
G
G
G
C
G
C
C
T
G
T
A
A
T
C
C
C
A
G
T
T
A
C
T
T
G
G
G
A
G
G
C
T
G
A
11600 |
var(11554):[C:0.22]
G
G
C
A
G
G
A
G
A
A
T
C
G
C
T
T
G
A
A
C
C
C
G
G
G
A
G
G
C
A
G
A
G
G
T
T
G
C
A
T
T
G
A
G
C
C
G
A
G
A
11650 |
var(11620):[T:0.08]
|
var(11623):[A:0.24]
|
var(11630):[G:0.22]
|
var(11633):[C:0.01]
C
T
G
T
G
C
C
A
C
T
G
C
A
C
T
C
C
A
G
C
C
T
G
G
G
G
G
A
C
G
A
G
A
G
C
A
A
G
A
C
T
T
C
A
T
G
T
C
A
A
11700 |
var(11669):[C:0.01]
|
var(11672):[C:0.17]
|
var(11679):[T:0.01]
A
A
A
A
G
A
A
A
A
A
G
A
A
A
A
A
T
T
A
G
C
C
G
G
A
T
G
T
G
G
T
G
G
C
A
C
A
T
G
C
C
T
G
T
A
A
T
A
C
C
11750 |
REPEAT
A
G
C
T
A
T
T
C
A
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
A
T
T
G
C
T
T
G
A
A
C
C
T
G
G
G
A
G
G
C
C
G
A
11800
G
G
T
T
G
C
A
C
T
G
A
G
C
C
G
A
G
A
T
T
G
T
G
C
C
A
C
T
G
C
A
C
T
C
C
A
G
C
C
T
G
G
G
T
G
A
C
A
G
A
11850 |
var(11808):[G:0.01]
|
var(11818):[T:0.01]
|
var(11820):[C:0.01]
G
T
G
A
G
A
C
T
C
C
A
T
C
T
C
A
A
A
A
C
A
A
A
A
A
C
A
A
A
A
A
C
A
A
A
A
G
C
A
A
A
A
A
CAAAACA
11900
AA
A
GTGTGTG CTCAGGAAAC AAGGTCCTCA TCACGAAATC CTTCCAAATC
11950 |
var(11903):[A:0.50]
CCCCATCTTG TCATCACCTG CGTTCTCAGG GTTTGAGAAC AGCGCCAGAC
12000
CTCATGGGGT GGCCCAGGTG ACACTGTGAG CTATTTACAA GTCAGTGTCT
12050
TATGGGAAAG GAGCACGTTT CCCTGAGAAC CTATTTGGTC CCCTCCAAGA
12100
GCTATGTTCG TTCAATACAA TTCAAATCAC GGCCCTTCAT GCGTCTGCTC
12150
GGGCCACCAT TATAAAATCC TACCCCCAGC TCCAAATACA GTCCCATTGA
12200
ACTTTGTGAT TTTGGAGAG
T
A
G
A
G
A
T
A
A
A
A
C
A
G
T
C
T
A
G
A
A
T
C
C
C
A
G
A
G
C
G
12250 |
REPEAT
A
T
T
T
T
A
C
C
A
T
A
C
C
A
T
G
G
C
A
A
A
C
T
G
A
C
T
C
T
C
A
A
C
T
T
T
A
G
A
A
A
C
A
C
A
A
A
T
G
C
12300
T
G
A
A
A
A
A
A
A
A
A
A
C
T
A
A
G
G
A
A
A
T
T
T
T
G
A
A
A
A
A
G
A
A
G
G
T
G
A
A
T
G
A
A
G
G
A
G
A
A
12350 |
var(12312):[:0.64]
C
C
T
G
C
C
T
T
A
C
C
T
A
T
A
T
C
A
A
A
A
G
G
C
A
C
T
G
A
A
A
A
G
T
T
C
A
T
A
C
C
C
A
A
T
G
T
G
C
G
12400
G
A
T
T
G
C
T
A
T
A
A
G
A
A
T
A
C
A
C
A
AGTA
G
G
C
C
G
G
G
C
G
T
G
G
T
G
G
C
T
C
A
C
G
C
C
T
G
T
12450 |
REPEAT
|
var(12434):[C:0.40]
C
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
A
G
G
C
C
G
A
G
G
C
G
G
G
T
G
G
A
T
C
A
C
G
A
G
G
T
C
A
G
G
A
G
A
T
12500 |
var(12480):[A:0.23]
C
G
A
G
A
C
C
C
T
C
C
T
G
G
C
T
A
A
C
A
C
G
G
T
G
A
A
A
C
C
C
C
G
T
C
T
C
T
A
C
T
A
A
A
A
A
T
A
T
A
12550 |
var(12508):[A:0.23]
|
var(12512):[C:0.22]
|
var(12514):[T:0.07]
|
var(12536):[A:0.36]
|
var(12550):[:0.62]
A
A
A
A
A
T
T
A
G
C
C
G
G
G
C
G
T
G
G
T
G
G
C
T
G
G
T
G
C
C
T
G
T
A
G
T
C
C
C
A
G
C
T
A
C
T
C
G
G
G
12600 |
var(12561):[T:0.02]
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
A
T
G
G
C
T
T
G
A
A
C
C
T
G
G
G
A
G
G
C
A
G
A
A
G
C
T
T
G
C
A
G
T
G
12650 |
var(12613):[T:0.06]
|
var(12614):[G:0.36]
A
G
C
C
G
A
G
A
T
C
G
C
G
C
C
A
C
T
G
C
A
C
T
C
C
A
G
C
C
T
G
G
G
C
G
A
C
A
G
A
G
C
G
A
G
A
C
T
C
T
12700
G
T
C
T
C
A
A
A
A
A
A
A
C
A
A
A
A
A
C
A
A
A
A
G
C
A
A
A
C
A
A
A
A
CGAAGAA TATACAAGTA
12750
GATTAATGAA ATGTGGCCGG GTGCGGTGG
T
G
A
G
G
C
A
G
G
A
G
A
A
T
T
G
C
T
T
G
A
12800 |
REPEAT
A
C
C
C
G
A
G
A
G
G
T
G
G
A
G
G
T
T
G
C
A
G
T
G
A
G
C
T
G
A
G
A
T
C
G
C
A
C
C
A
C
T
G
A
A
G
T
C
T
A
12850 |
var(12848):[G:0.43]
G
C
C
T
G
G
G
C
A
A
G
C
G
G
A
G
T
G
A
G
G
C
C
C
T
G
T
C
T
T
A
A
C
A
A
A
A
A
A
A
C
A
A
A
G
A
A
A
C
A
12900
A
A
A
A
A
C
A
A
A
C AAACAAGAAA AAAACAAAGC AAAACAAACA GAAAAGTATT
12950
TCACTAATAT TTACTGCTAA GTGGGATTAT TTTTATTCAA GCTTTTGTAT
13000
CTTTAGAAAA AAATTGT
G
G
C
C
G
G
G
C
G
C
G
G
T
G
G
C
T
C
A
C
G
C
C
T
G
T
C
A
T
C
C
C
A
13050 |
REPEAT
|
var(13028):[A:0.05]
|
var(13033):[T:0.01]
G
C
A
C
T
T
T
G
G
G
A
G
G
C
C
G
A
G
G
A
G
G
G
T
G
G
A
T
C
A
C
G
A
G
G
T
C
A
G
G
A
G
A
T
C
G
A
G
A
C
13100 |
var(13074):[C:0.11]
C
C
T
C
C
T
G
G
C
T
A
A
C
A
C
G
G
T
G
A
A
A
C
C
C
C
G
T
C
T
C
T
A
C
T
A
A
A
A
A
T
A
T
A
A
A
A
A
A
T
13150 |
var(13149):[:0.99]
T
A
G
C
C
G
G
G
C
G
T
G
G
T
G
G
C
G
G
G
C
G
C
C
T
G
T
A
G
T
C
C
C
A
G
C
T
A
C
T
T
G
G
G
A
G
G
A
T
G
13200 |
var(13168):[A:0.26]
|
var(13179):[C:0.13]
A
G
G
C
A
G
G
A
G
A
A
T
G
G
C
A
T
G
A
A
C
C
C
G
G
G
A
G
G
G
A
G
A
G
G
C
T
A
C
A
G
T
G
A
G
C
C
G
A
G
13250 |
var(13247):[T:0.15]
A
T
C
G
C
G
C
C
C
C
T
G
C
A
C
T
C
C
A
G
C
C
T
G
G
G
C
G
A
C
A
G
A
G
C
G
A
G
A
C
T
C
C
C
T
C
T
C
A
A
13300 |
var(13253):[T:0.04]
A
A
A
A
A
A
A
A
A
A
A
A
C
A
G
A
A
A
A
A
A
GTCTT
G
G
C
C
G
G
G
C
A
C
G
G
T
G
G
C
T
C
A
C
G
C
C
T
13350 |
REPEAT
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
C
G
G
A
T
C
A
C
A
T
G
A
G
G
T
C
A
G
13400
G
A
G
T
T
C
G
A
G
A
C
C
A
G
C
C
T
G
A
C
C
A
A
C
A
T
G
G
T
G
A
A
A
C
C
C
T
G
T
C
T
C
T
A
C
C
C
A
G
A
13450 |
var(13419):[G:0.14]
A
A
A
A
T
A
C
T
T
T
A
A
A
A
A
T
T
A
G
C
T
G
G
G
C
G
T
G
G
T
G
G
C
G
G
G
C
A
C
C
T
G
T
A
A
T
C
C
C
A
13500 |
var(13457):[:0.01]
G
G
T
G
C
T
C
G
G
G
A
G
G
T
T
G
A
A
G
C
A
G
G
A
G
A
A
T
G
G
C
T
T
G
A
A
C
C
C
G
G
G
A
G
G
G
A
G
A
G
13550 |
var(13510):[T:0.07]
G
C
T
G
C
A
G
T
G
A
G
C
C
G
A
G
A
T
C
A
C
G
C
C
A
C
T
G
C
A
C
T
C
C
A
G
C
C
T
G
G
G
C
G
A
C
G
A
G
A
13600 |
var(13570):[G:0.15]
|
var(13588):[G:0.44]
G
C
G
A
A
A
C
T
C
T
G
C
C
T
C
A
A
A
A
A
A
A
A
TCTGAAC AT
C
ATTAGCG TCAAATTAAG
13650 |
var(13615):[G:0.01]
|
var(13633):[G:0.02]
CATGGTCT
G
T CAGCAGCCAT CATAGTCCTA TGTCTCTCTT AG
G
C
A
G
T
G
A
A
13700 |
var(13659):[C:0.41]
| Exon 4
A V N 64
C
A
A
T
A
G
C
T
A
T
T
G
C
C
A
G
T
T
T
G
G
A
G
C
A
A
T
T
T
C
C
T
T
A
T
G
T
G
A
A
G
T
G
A
C
C
A
A
C
T
13750 |
var(13739):[G:0.01]
N S Y C Q F G A I S L C E V T N 80
A
C
A
C
C
G
T
C
C
G
A
G
T
G
G
C
C
A
A
C
C
C
A
C
C
A
T
T
C
T
C
C
A
C
G
T
G
G
A
T
C
C
T
C
T
T
C
C
C
T
13800 |
var(13773):[C:0.12]
Y T V R V A N P P F S T W I L F P 97
G
A
G
A
A
C
A
GTG AGAAAAATGT TCATTGTTTG TTTATTCTCT ATTCCCTCCC
13850
E N 99
TCCTTCCCTC TCTCCCTCCC TCTCGCCTTC GCTGTGTCTT TTTTCTTTTC
13900
TTTTTCTCTT TCTTTCTTTC TTTCTTTCTT TCTTTCTTTC TTTCTTTCTT
13950
TCTTTTTCTT TCT
T
T
C
T
G
T
T
T
C
T
G
T
T
T
C
T
T
T
C
T
T
C
C
T
T
T
C
T
T
T
T
T
C
T
T
T
C
14000 |
NOT SCANNED
T
T
T
C
T
T
T
C
C
T
T
C
T
T
T
C
C
T
C
T
C
T
T
T
C
T
T
T
T
C
T
T
T
C
T
C
T
T
T
C
C
C
T
C
C
C
T
C
C
C
14050
T
T
C
T
T
T
C
T
T
T
T
C
T
T
C
A
C
T
T
C
C
T
T
C
C
C
T
C
C
C
T
C
C
T
T
C
T
C
T
C
C
T
T
T
T
C
C
T
C
C
14100
C
T
C
C
T
C
C
T
T
C
C
C
A
C
C
C
T
A
C
T
T
C
C
T
C
T
C
T
C
T
C
C
T
T
C
C
T
T
C
C
C
T
T
T
C
G
T
T
T
T
14150
C
T
T
T
T
C
C
T
C
C
C
T
G
C
C
T
C
A
C
T
C
C
C
T
T
C
C
T
T
C
C
T
T
C
T
C
T
C
C
C
T
C
C
T
C
T
T
T
T
C
14200
C
T
T
C
C
T
T
C
T
T
C
C
C
T
C
C
T
T
C
C
C
T
T
T
C
T
C
T
C
T
C
T
C
T
C
T
C
T
T
T
C
T
C
T
C
T
T
T
C
C
14250
C
C
C
T
C
C
C
C
T
C
C
C
T
T
C
C
C
C
T
C
C
T
C
T
C
C
C
C
T
C
T
C
C
T
T
T
C
C
T
G
A
C
A
C
G
G
T
C
T
T
14300 |
REPEAT
G
C
T
C
T
G
T
T
G
C
C
C
A
G
G
C
T
G
G
A
G
C
G
C
A
G
T
G
G
T
G
C
A
A
T
C
A
C
A
G
C
T
T
A
C
T
G
C
A
G
14350
G
C
T
T
C
A
C
C
T
C
C
T
G
A
G
C
T
C
A
A
A
C
A
A
T
C
C
T
T
C
T
G
C
C
T
C
A
G
C
C
T
C
C
C
A
C
G
T
A
G
14400
G
T
G
G
A
A
C
T
A
C
A
C
C
C
A
T
G
T
A
C
C
A
C
C
A
T
G
C
C
C
A
C
C
T
A
A
T
T
T
T
T
T
A
A
A
C
A
C
C
T
14450 |
REPEAT
T
T
T
T
T
T
T
T
T
T
T
T
A
G
A
C
A
G
A
G
T
C
T
C
A
C
T
C
T
G
T
C
C
A
C
C
A
G
G
C
T
G
G
A
G
T
G
C
A
C
14500
T
G
G
C
G
C
G
A
T
C
T
C
G
G
C
T
C
A
C
T
G
C
A
A
C
C
T
C
T
G
G
C
T
C
C
C
G
G
G
T
T
C
A
A
G
C
G
A
T
T
14550
C
T
C
C
T
G
C
C
T
C
A
G
C
C
T
C
C
C
G
A
G
T
A
G
C
T
G
G
G
A
T
T
A
T
A
G
G
C
G
C
C
C
A
C
C
G
C
C
A
C
14600
G
C
C
C
A
G
C
T
A
A
T
T
C
T
T
G
T
A
C
T
T
T
T
A
G
T
A
G
A
G
A
T
G
G
G
G
T
T
T
C
A
C
C
A
T
G
T
T
G
G
14650 |
var(14619):[T:0.38]
T
C
A
G
G
C
T
G
G
T
C
T
C
A
A
A
C
T
C
C
T
G
A
C
T
T
C
G
T
G
A
T
C
T
G
C
C
C
G
C
C
T
C
G
G
C
C
T
C
C
14700
C
A
A
A
G
T
G
C
T
G
G
G
A
G
T
A
C
A
G
G
G
G
T
G
A
G
C
C
A
C
C
G
C
G
C
C
C
A
G
C
C
T
T
A
A
A
T
A
C
T
14750 |
REPEAT
T
T
T
T
G
T
A
G
A
G
A
T
G
G
G
G
T
G
T
C
G
C
T
A
T
G
T
T
A
C
C
T
G
A
G
C
T
G
G
T
C
T
C
A
A
A
C
T
C
C
14800
T
A
G
G
C
T
C
A
A
G
T
G
A
T
C
C
T
C
C
C
G
C
C
T
C
A
G
T
C
T
C
C
C
A
A
A
G
T
G
C
A
G
G
G
A
T
T
G
T
A
14850
A
G
C
A
T
C
A
G
C
C
A
C
C
A
C
G
C
C
T
G
G
C
C
TCTTCTT TGTTTTT
G
AA TTAATTAGAA
14900 |
var(14888):[T:0.38]
GTCCATGGTT TA
T
T
T
T
T
T
T
G
T
T
T
T
G
T
T
T
T
G
T
T
T
G
T
T
T
T
T
C
T
G
T
G
A
T
G
G
A
G
14950 |
REPEAT
T
C
T
T
G
T
T
C
T
T
G
T
C
G
C
C
C
A
G
G
C
T
G
G
A
G
T
G
C
A
G
T
G
G
T
G
C
G
A
T
T
T
C
A
G
C
T
T
A
C
15000
C
G
C
A
A
A
C
T
C
C
G
C
C
T
C
C
C
G
G
G
T
T
C
A
A
G
C
G
A
T
T
C
T
C
C
T
G
C
C
T
C
A
G
C
C
T
C
A
C
A
15050 |
var(15037):[C:0.01]
A
G
T
A
G
C
T
G
G
G
A
T
T
A
C
A
G
G
C
A
C
C
C
G
C
C
A
C
C
A
A
G
C
C
C
G
G
C
T
A
A
A
T
T
T
T
G
T
A
T
15100 |
var(15086):[A:0.07]
T
T
T
A
A
G
T
A
G
A
G
A
C
G
G
G
G
C
T
T
C
A
C
C
A
T
G
T
T
G
G
T
C
T
C
G
A
A
C
T
C
C
T
G
A
C
C
T
T
G
15150 |
var(15150):[C:0.06]
T
G
A
T
C
C
A
C
C
C
G
C
C
T
C
A
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
G
A
C
A
G
G
C
G
G
G
A
G
C
C
15200
A
C
T
G
T
G
C
C
G
G
G
C
C
TCAATTT AATTATTTTT AAGTTTA
A
T
G
G
A
T
T
T
C
C
A
G
G
15250 |
REPEAT
G
A
G
T
T
A
T
G
C
C
G
A
G
T
C
G
G
A
A
A
A
A
A
A
A
G
A
C
C
A
C
T
C
C
A
G
A
G
C
G
T
G
A
C
A
C
A
C
A
C
15300
A
G
T
G
A
T
T
T
C
A
T
T
A
A
T
A
C
A
A
C
T
G
T
C
T
T
G
A
A
A
T
G
G
C
A
A
A
A
T
T
T
T
A
C
A
A
A
T
A
G
15350 |
NOT SCANNED
A
A
A
A
C
A
G
T
C
T
C
C
T
G
G
G
T
T
G
C
A
G
G
G
A
T
A
T
A
A
G
C
A
G
G
A
G
T
G
A
G
A
G
C
T
G
A
G
A
G
15400
A
G
G
T
G
G
G
T
T
T
G
G
C
T
G
T
A
A
A
A
G
T
G
C
T
C
C
T
T
G
G
G
G
A
G
G
C
C
G
G
G
C
G
C
A
G
T
G
G
C
15450 |
REPEAT
T
C
A
C
G
C
C
T
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
C
G
A
G
G
C
G
G
G
C
G
G
A
T
C
A
C
C
T
15500
G
A
G
G
T
C
A
G
G
A
G
T
T
C
G
A
G
A
C
C
A
G
C
C
T
G
G
C
C
A
A
C
A
T
G
G
T
G
A
A
A
C
C
C
C
G
T
C
T
C
15550
T
A
C
T
A
A
A
A
A
C
A
C
A
A
A
A
A
T
T
A
G
C
C
G
G
G
C
A
T
G
G
T
G
G
C
T
C
A
C
G
C
C
T
G
T
A
A
T
C
C
15600 |
REPEAT
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
C
G
A
G
G
C
A
G
G
C
G
G
A
T
C
A
C
C
T
G
A
G
G
T
C
A
G
G
A
A
T
T
C
G
15650
A
G
A
C
C
A
G
C
C
T
G
G
C
T
A
A
C
A
T
G
G
T
G
A
A
A
C
C
C
C
A
T
C
T
C
T
A
C
T
A
A
A
A
A
T
A
C
A
A
A
15700
A
T
T
A
G
C
C
A
G
G
G
G
T
G
G
T
G
G
C
A
C
A
T
G
C
C
T
G
T
A
G
T
C
C
C
A
G
C
T
A
C
T
C
A
G
G
A
G
G
C
15750
T
G
A
G
G
C
A
G
G
A
G
A
A
T
C
A
C
T
T
G
A
A
C
C
C
G
G
G
A
G
G
C
G
G
A
G
A
T
T
G
C
G
G
T
G
A
G
C
T
G
15800
A
G
A
T
C
G
T
G
C
C
A
T
T
G
C
T
C
T
C
C
A
G
C
C
T
G
G
G
C
A
A
C
A
A
G
A
G
T
G
A
A
A
T
T
C
C
A
T
C
T
15850
A
A
A
A
A
A
A
A
A
A
A
A
A
A
A
T
T
A
A
A
A
A
G
A
A
A
T
T
A
G
C
G
G
C
C
G
G
G
C
C
C
A
G
T
G
G
C
T
C
A
15900 |
REPEAT
C
A
C
C
T
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
C
G
A
G
G
T
G
G
G
T
G
G
A
T
C
G
C
G
A
G
G
T
15950
C
A
G
G
A
G
A
T
C
G
A
G
A
C
C
A
T
C
C
C
G
G
C
T
A
A
C
A
T
G
G
T
G
A
A
A
C
C
C
C
A
T
C
T
C
T
A
C
T
A
16000
A
A
A
A
T
A
C
A
A
A
A
T
T
A
G
C
C
A
G
G
G
G
T
G
G
T
G
G
C
A
C
A
T
G
C
C
T
G
T
A
G
T
C
C
C
A
G
C
T
A
16050
C
T
C
A
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
A
T
C
A
C
T
T
G
A
A
C
C
T
G
G
G
A
G
G
C
G
G
A
G
G
T
T
G
16100
T
G
G
T
G
A
G
C
C
A
T
T
G
A
G
C
T
C
C
A
G
C
C
T
G
G
G
C
A
A
C
A
A
G
A
G
T
G
A
A
A
C
T
C
T
G
T
C
T
T
16150
A
A
G
ACAAACA CACACACACA GATGCACACA CACGCACACA CACACAAACA
16200
A
T
G
A
A
A
G
A
A
A
A
A
C
A
T
C
T
G
T
A
G
T
C
C
C
A
G
C
A
G
T
T
T
G
G
G
A
G
G
C
T
G
A
G
G
C
G
G
G
T
16250 |
REPEAT
|
REPEAT
G
G
A
T
C
A
C
T
T
G
A
G
G
T
C
A
G
G
A
G
T
T
C
G
C
G
A
C
C
A
G
T
C
T
G
G
G
C
A
A
C
A
T
G
G
T
G
A
A
A
16300 |
var(16270):[A:0.27]
C
C
C
C
A
T
C
T
C
T
A
C
T
A
A
A
A
A
T
A
C
A
A
A
A
A
T
T
A
G
C
T
G
G
G
T
G
T
G
G
T
A
G
T
G
G
G
C
G
C
16350 |
var(16348):[T:0.24]
C
T
G
T
T
G
T
C
C
C
A
G
A
T
A
C
T
T
G
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
A
T
T
G
C
T
T
G
A
A
C
C
C
16400
G
G
G
A
G
G
C
G
G
A
G
G
T
T
G
C
A
G
T
G
A
G
C
C
G
A
G
A
T
G
G
C
G
C
C
A
T
T
G
T
A
C
T
C
C
A
G
C
C
T
16450 |
var(16407):[T:0.21]
A
G
G
C
G
A
C
G
G
A
G
C
G
A
G
A
C
T
C
T
G
T
A
A
A
A
A
T
G
A
A
T
A
A
A
T
A
A
A
T
C
A
T
T
A
A
A
A
G
A
16500 |
NOT SCANNED
|
REPEAT
A
T
A
T
G
C
A
G
G
A
T
C
T
C
T
C
C
A
T
A
T
T
A
T
T
A
T
T
A
T
T
T
T
T
T
A
C
A
A
C
G
G
C
T
T
G
T
G
T
A
16550
T
C
T
A
C
C
A
T
G
G
T
C
T
C
A
A
A
A
T
A
C
A
A
A
A
G
G
C
A
C
T
C
T
A
A
A
A
A
G
G
A
A
T
T
A
G
A
G
T
T
16600 |
REPEAT
T
T
A
T
T
T
T
T
T
T
T
T
T
T
G
A
G
A
C
G
G
A
G
T
C
T
C
G
C
T
C
T
T
G
T
C
A
C
A
C
A
G
G
C
T
G
G
A
G
T
16650
G
C
A
G
T
G
A
C
G
T
G
G
C
C
T
G
G
G
C
T
C
A
C
T
G
C
A
A
C
C
T
C
T
G
C
C
T
C
C
T
G
G
G
T
T
C
A
A
G
A
16700
A
A
T
T
C
T
C
C
T
G
C
C
T
C
A
G
C
C
T
C
C
C
T
A
G
T
A
G
C
T
G
G
G
A
T
T
A
C
A
G
C
G
G
C
C
C
G
A
C
A
16750
T
C
A
C
G
C
C
C
G
G
C
T
A
A
T
T
T
T
T
G
T
A
T
T
T
T
T
A
G
T
A
G
A
G
G
C
A
G
G
G
T
T
T
C
A
C
C
A
T
G
16800
T
T
A
G
C
C
A
G
G
C
C
G
G
T
C
T
C
G
A
A
C
T
C
C
G
G
A
C
C
T
C
A
G
G
T
G
A
T
C
C
T
C
C
T
G
C
C
T
C
G
16850
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
T
A
C
A
G
G
C
G
T
G
A
G
C
C
A
C
C
A
T
G
C
C
T
G
G
G
T
T
T
G
16900 |
REPEAT
T
T
T
T
T
T
T
A
T
T
T
T
T
T
T
G
A
G
A
C
G
A
A
G
G
C
T
C
A
C
T
C
T
G
T
C
G
C
C
C
A
G
G
C
T
G
G
A
G
T
16950
G
C
A
G
T
G
G
C
G
T
G
A
T
C
T
C
A
G
C
T
C
C
A
T
G
C
A
A
C
C
T
C
T
G
C
C
T
C
C
T
G
G
G
T
T
C
A
A
G
A
17000
A
A
T
T
C
T
C
C
T
G
C
C
T
C
A
G
C
C
T
C
C
C
G
A
G
T
A
G
C
T
G
G
G
A
T
T
A
C
A
G
C
G
G
C
C
C
G
A
C
A
17050
T
C
A
C
A
C
C
T
G
G
C
T
A
A
T
T
T
T
T
T
A
T
A
T
T
T
T
T
A
G
T
A
G
A
G
A
C
T
G
G
G
T
T
T
C
A
C
C
A
T
17100
G
T
T
A
G
C
C
A
G
G
C
T
G
G
T
C
T
C
G
A
A
C
T
C
C
G
G
A
C
C
T
C
G
G
G
T
G
A
T
C
C
A
C
C
T
G
C
C
T
C
17150
G
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
C
A
C
A
G
G
T
G
C
G
T
G
C
C
A
C
C
A
G
A
C
A
C
A
G
C
T
A
A
17200 |
REPEAT
T
T
T
T
T
G
C
A
T
T
T
T
T
A
G
T
A
G
A
G
A
T
T
G
G
G
T
T
T
C
T
C
C
A
T
G
T
T
G
G
C
C
A
G
G
C
T
G
G
T
17250
C
T
C
G
A
A
C
T
C
C
T
G
A
C
C
T
C
A
T
G
T
G
A
T
C
C
A
C
C
C
G
C
C
T
C
G
G
C
C
T
C
C
C
A
A
A
A
T
G
C
17300
T
G
G
G
G
T
G
A
C
A
G
G
C
G
T
G
A
G
C
C
A
C
C
G
C
G
C
C
C
G
G
T
C
C
C
G
A
T
T
C
G
A
G
T
T
C
T
C
T
T
17350
T
C
A
T
G
T
T
T
G
T
G
A
A
C
C
C
A
G
G
T
G
G
G
A
A
G
C
C
T
T
G
G
G
C
A
G
G
T
G
C
G
G
A
G
A
A
T
C
T
G
17400 | Exon 5
S G K P W A G A E N L 110
A
C
C
T
G
C
T
G
G
A
T
T
C
A
T
G
A
C
G
T
G
G
A
T
T
T
C
T
T
G
A
G
C
T
G
C
A
G
C
T
G
G
G
C
G
G
T
A
G
G
17450 |
var(17438):[C:0.01]
|
var(17445):[A:0.01]
T C W I H D V D F L S C S W A V G 127
C
C
C
G
G
G
G
G
C
C
C
C
C
G
C
G
G
A
C
G
T
C
C
A
G
T
A
C
G
A
C
C
T
G
T
A
C
T
T
G
A
A
C
G
T
T
G
C
C
A
17500
P G A P A D V Q Y D L Y L N V A 143
A
GTAGGTGTG CCC
T
TGGGCA GAGGCCGGGC TGTCC
C
TGGT GC
G
GGTGCCA
17550 |
var(17514):[G:0.21]
|
var(17536):[G:0.04]
|
var(17543):[T:0.03]
N 144
TCGGCGTGGG GTCGTCCCCC AACCTT
A
CCG CTTACCGCAG
C
A
G
G
C
G
T
C
A
A
17600 |
var(17577):[G:0.04]
| Exon 6
R R Q 147
C
A
G
T
A
C
G
A
G
T
G
T
C
T
T
C
A
C
T
A
C
A
A
A
A
C
G
G
A
T
G
C
T
C
A
G
G
G
A
A
C
A
C
G
T
A
T
C
G
G
17650
Q Y E C L H Y K T D A Q G T R I G 164
G
T
G
T
C
G
T
T
T
C
G
A
T
G
A
C
A
T
C
T
C
T
C
G
A
C
T
C
T
C
C
A
G
C
G
G
T
T
C
T
C
A
A
A
G
T
T
C
C
C
17700
C R F D D I S R L S S G S Q S S 180
A
C
A
T
C
C
T
G
G
T
G
C
G
G
G
G
C
A
G
G
A
G
C
G
C
A
G
C
C
T
T
C
G
G
T
A
T
C
C
C
C
T
G
C
A
C
A
G
A
T
17750
H I L V R G R S A A F G I P C T D 197
A
A
G
T
T
T
G
T
C
G
T
C
T
T
T
T
C
A
C
A
G
A
T
T
G
GTGAG TAGCCCGGGA CACTCCCTCC
17800
K F V V F S Q I 205
CACCCTCAGT TCTGTGATAC CACGGCTTTA GCGCCAGG
C
C AGATCCCACG
17850 |
var(17839):[T:0.04]
GGACCACGTG GCTCCCAACG
C
A
G
A
C
G
T
T
G
G
C
C
T
C
T
C
A
C
A
T
T
T
C
C
A
G
A
G
G
C
17900 |
REPEAT
T
G
G
A
C
G
T
T
G
G
A
G
G
T
C
A
G
G
G
T
G
C
T
G
G
C
T
G
G
C
T
G
G
G
C
T
C
C
T
C
G
G
G
A
G
G
T
C
T
C
17950 |
var(17918):[C:0.20]
T
T
C
C
T
G
G
C
T
T
G
G
A
G
A
G
A
G
G
G
T
C
A
T
C
T
T
C
T
C
A
C
T
G
T
G
T
C
T
T
C
A
T
G
T
G
G
T
G
G
18000 |
var(17993):[C:0.20]
|
var(18000):[T:0.23]
A
G
A
G
A
G
A
G
A
G
A
G
A
G
A
T
G
A
A
G
T
T
C
T
G
G
G
G
T
C
T
C
T
T
G
T
T
A
G
A
A
G
G
G
C
A
C
T
A
A
18050 |
var(18009):[T:0.03]
C
A
C
C
A
T
C
A
T
G
G
G
T
C
C
C
A
T
C
A TGGGTCATAG GATCCCTCA
T
CATGGGTCAT
18100 |
var(18090):[C:0.19]
GGGACCCCCC ATCATGGGTT CCATCATGG
G
TCCCATCATG GGTCATAGAA
18150 |
var(18130):[A:0.09]
TCCCCCAT
C
A TGGGTTTCAT CATGAGTCAT AGAACCCCCT ATCATGGATT
18200 |
var(18159):[G:0.20]
CCATCATGGG TCATGGGAAC CCCCATCATG GGTCCCATCA TGGTTCATAG
18250
GATCCCCCAT CATGGGTTTC ATCATGAGTC ATAGAACCCC CTATCATGGA
18300
TTCCATCATG GGTCATGGGA ACCCCCATCA TGGGTCCCAT CATTGGTCAT
18350
AGGACCCCCT ATCATGGGTT CCATCATGGG TCATGGGACA CCCCCCATCA
18400
TGGGTTCCAC C
A
T
G
A
G
T
C
A
T
G
G
G
A
T
C
C
C
T
C
A
T
C
G
T
G
G
G
T
T
C
C
A
T
C
A
T
G
G
G
18450 |
NOT SCANNED
T
C
A
T
G
G
G
A
C
C
C
C
C
C
A
T
C
A
T
G
G
G
T
T
C
C
A
T
C
A
T
G
G
G
T
A
A
T
A
G
G
A
C
C
C
C
C
C
C
A
18500
T
C
A
T
G
G
G
T
T
C
C
A
C
C
A
T
G
A
G
T
C
A
T
G
G
G
A
T
C
C
C
T
C
A
T
C
A
T
G
G
G
T
T
C
C
A
T
C
A
T
18550
G
G
G
T
C
A
T
G
G
G
A
C
C
C
C
C
T
A
T
C
A
T
G
G
A
T
T
C
C
A
T
C
A
T
G
G
G
T
C
A
T
G
G
G
A
C
C
C
C
C
18600
C
C
A
T
C
A
T
G
G
G
T
C
C
C
A
T
C
A
T
G
A
G
T
C
A
T
G
G
G
A
T
C
C
C
T
C
A
T
C
A
T
G
G
G
T
T
T
C
A
T
18650
C
A
T
G
G
G
T
C
A
T
A
G
G
A
C
C
C
C
C
A
T
C
A
T
G
G
A
T
T
C
C
A
T
C
A
T
G
G
G
T
C
A
T
G
G
G
A
A
C
C
18700
T
C
C
A
T
C
A
T
G
G
G
T
C
C
C
A
T
T
A
T
G
G
GTCATAGA ATTCCCCATC ATGGGTTCCA
18750
TCATGAGTCA TGGGACCCCC CATCATGGGT TCCACATGGG ATCCCTCATC
18800
ATTGGTTCCA TCATGGGTCA TAGGATCCCC CATCATAGGT CCCATCATGG
18850
GTTCCACATG GGATCCC
T
CA TCAT
T
GGT
T
C CATCATGGGT CAT
A
GGA
T
CC
18900 |
var(18868):[C:0.23]
|
var(18875):[A:0.22]
|
var(18879):[C:0.14]
|
var(18894):[G:0.24]
|
var(18898):[C:0.21]
CCC
C
C
ATCAT GGGTTCCATC ACGGGTCATG GGACCCCCCC CATCATGGGT
18950 |
var(18904):[:0.81]
TCCATCACGG GTCATGGGAC CCCCCCCAA
T
C
A
T
G
G
G
T
T
C
C
A
T
C
A
T
G
G
G
T
C
19000 |
NOT SCANNED
A
T
G
G
G
A
A
C
C
C
C
C
A
T
C
A
T
G
G
G
T
T
T
C
A
T
C
A
T
G
G
G
T
C
A
T
A
G
G
A
T
C
C
C
C
T
A
T
C
A
19050
T
G
G
G
T
T
C
C
A
T
C
A
T
G
G
G
T
C
A
T
G
G
G
A
C
C
C
C
C
C
C
C
A
T
C
A
C
G
G
G
T
T
C
C
A
T
C
A
T
G
19100
G
G
T
C
A
T
G
G
G
A
A
C
C
C
C
C
A
T
C
A
T
G
G
G
T
T
T
C
A
T
C
A
T
G
G
G
T
C
A
T
A
G
G
A
T
C
C
C
C
T
19150
A
T
C
A
T
G
G
A
T
T
C
C
A
T
C
A
T
G
A
G
T
C
A
T
G
G
G
A
T
C
C
C
T
C
A
T
C
A
T
G
G
G
T
T
C
C
A
T
C
A
19200
T
G
GGTCATGG GACCCCCCCC CCCATCATGG GTCGTGGGAC CCCCACCCCC
19250
ATCATGGGTC ATGGGAGCCC CCATTGTGAG TCATGGAATC CCTCATCATG
19300
GGTCTCATCA TGGGCCATGG GTCCCACCAT GGGTCATGGG AGCCCCCATC
19350
ATGAGTCATG GAATCCCTCA TCATGGGTCA TGGGTCCCAT C
A
TGGGTCAT
19400 |
var(19392):[C:0.03]
GGGAGCCCCC ATCATGGGTC ATGGGTCCCA TCATGGGTCA CGGGAGCC
C
C
19450 |
REPEAT
C
A
T
C
A
T
G
G
G
G
G
T
C
C
A
C
C
C
T
C
A
T
A
A
C
T
T
C
A
G
C
C
C
A
C
G
C
C
A
G
T
C
A
C
C
T
C
C
C
A
19500 |
var(19461):[T:0.01]
|
var(19467):[T:0.05]
A
A
G
A
C
C
C
C
A
C
C
T
T
C
T
A
A
C
A
C
C
G
C
C
C
A
A
C
C
A
G
G
G
G
T
T
A
G
A
G
C
T
T
C
A
G
T
G
G
A
19550
G
G
A
A
T
T
T
G
G
G
A
C
A
G
A
A
G
G
A
C
A
C
A
C
A
C
T
T
T
C
A
G
T
C
C
A
C
GAT ACCC
G
AGCTC
19600 |
var(19587):[T:0.01]
|
var(19595):[A:0.03]
CGAGGAACCT CCCAGGTGGT GA
A
A
A
T
G
T
C
A
A
T
A
T
G
C
C
C
A
G
A
G
C
T
G
A
C
G
T
G
19650 |
var(19623):[G:0.27]
|
NOT SCANNED
C
C
C
T
G
A
A
C
C
C
A
A
G
G
G
C
A
G
G
G
T
G
C
T
C
G
G
A
T
G
C
T
T
C
A
G
A
A
G
A
G
G
A
G
G
G
G
G
A
A
19700
A
C
G
A
G
G
A
A
G
A
G
G
A
G
G
A
G
A
A
G
G
A
C
A
A
G
G
A
G
A
A
G
A
G
A
A
G
G
G
A
G
G
A
G
A
G
G
A
A
G
19750
A
A
C
A
T
G
A
G
C
A
G
G
G
G
G
A
G
G
A
G
G
A
G
G
A
G
A
A
G
G
A
A
A
A
G
A
A
A
C
A
G
A
G
G
A
A
A
A
G
G
19800
A
G
G
G
G
G
A
G
G
A
G
G
T
A
G
A
G
A
T
G
G
A
G
A
G
G
G
A
A
G
G
A
A
G
A
G
G
A
G
G
A
A
G
A
G
A
A
G
A
A
19850
A
A
C
G
G
A
G
A
A
A
G
A
G
G
A
G
G
G
G
G
A
G
G
A
G
G
A
G
G
A
G
G
A
A
G
A
G
A
A
A
A
T
G
G
A
G
A
A
A
G
19900
A
G
G
A
G
G
G
G
G
A
G
G
A
G
G
T
G
G
A
G
A
T
G
G
G
G
A
G
G
G
G
A
G
G
A
A
G
A
G
G
A
G
G
A
A
G
A
G
A
A
19950
G
A
A
A
A
C
A
G
G
A
G
G
G
G
G
A
G
G
A
A
G
A
G
A
A
G
A
A
A
A
T
G
G
A
G
G
G
A
A
A
G
G
A
G
G
G
G
G
A
G
20000
G
A
G
G
T
G
G
A
G
A
T
G
G
G
G
A
G
A
G
A
A
G
G
A
G
C
A
G
G
A
G
G
A
G
G
A
G
A
A
G
A
A
A
G
A
A
G
A
G
G
20050
A
A
G
A
A
A
G
G
A
G
G
A
G
G
A
G
A
G
G
G
T
G
G
A
G
G
A
G
G
A
A
G
A
G
G
G
T
G
A
A
G
G
A
G
A
G
A
G
G
G
20100
A
G
G
A
G
A
A
T
G
G
A
G
A
G
G
A
G
G
A
G
G
A
G
G
C
G
G
G
G
G
A
G
G
G
A
A
G
A
G
A
A
G
G
A
G
G
T
G
A
G
20150
G
A
G
G
A
G
G
A
A
G
G
G
G
A
G
G
A
T
A
G
A
G
A
A
G
G
T
G
G
G
G
T
A
G
A
A
G
G
G
T
G
G
T
G
A
G
G
T
G
G
20200
G
G
A
G
G
G
A
G
A
A
G
G
A
G
G
G
G
G
A
G
G
A
G
G
A
G
A
G
A
G
G
A
G
G
A
C
T
G
G
G
G
G
G
A
G
G
A
A
G
G
20250
G
G
G
A
G
G
A
G
G
G
G
A
G
A
G
A
G
G
A
G
G
A
G
G
G
A
G
G
A
G
G
G
A
G
A
A
G
G
A
G
G
G
G
G
A
G
A
G
G
A
20300
T
G
G
A
G
G
A
A
G
G
G
G
A
G
C
A
G
A
T
G
G
A
G
G
A
A
G
G
C
G
A
G
C
A
G
G
A
G
G
G
G
G
A
G
G
A
A
A
A
A
20350
G
G
A
G
G
G
G
C
A
G
G
A
G
G
A
A
G
A
A
G
G
A
G
C
G
G
G
A
G
G
A
G
A
G
G
A
G
G
A
G
G
A
G
G
A
G
G
A
G
G
20400
A
G
A
A
T
G
G
G
C
A
G
G
G
A
G
G
A
G
G
A
G
A
G
G
G
A
A
G
A
A
A
A
G
G
A
G
G
G
G
G
A
G
G
A
G
G
A
A
G
G
20450
A
G
G
G
G
G
A
G
G
A
G
G
G
T
G
G
A
G
G
G
G
G
A
G
G
A
G
G
G
T
G
G
A
G
G
G
G
G
A
G
G
A
G
G
G
T
G
G
A
G
20500
G
G
G
G
A
G
G
A
G
G
A
A
G
G
A
G
G
G
A
G
A
A
G
G
A
G
G
G
G
A
G
A
G
G
A
T
G
G
A
G
G
A
A
G
A
G
G
A
G
C
20550
A
G
G
A
G
G
G
G
G
A
G
G
A
A
A
A
A
G
G
A
G
G
A
G
G
G
G
C
A
G
G
A
G
G
G
G
A
G
G
A
G
G
A
G
A
A
A
G
G
A
20600
G
A
G
T
G
G
A
G
G
A
G
G
A
G
G
G
T
G
A
C
A
A
G
G
A
G
A
A
T
G
G
G
G
A
G
G
A
G
A
G
A
G
G
A
G
T
G
G
T
A
20650
G
A
A
A
A
A
G
G
A
G
A
G
A
G
A
G
G
A
A
G
A
G
T
A
G
G
A
G
C
G
G
A
G
G
G
G
G
A
G
G
A
G
G
G
G
A
G
G
G
G
20700
A
G
G
G
G
A
G
G
G
G
A
G
A
A
A
G
A
C
C
A
G
G
A
G
G
G
T
A
G
G
A
G
G
A
G
G
G
G
G
A
G
G
A
G
G
A
G
G
A
G
20750
G
G
G
G
C
C
A
G
G
G
C
T
G
G
A
C
T
T
C
C
T
T
C
C
A
G
G
G
G
C
C
C
A
G
G
G
G
A
G
A
C
C
C
A
G
C
C
A
G
G
20800
C
A
G
C
C
G
G
A
C
A
C
A
C
A
G
G
G
C
T
G
G
G
C
T
G
G
T
A
G
T
C
G
G
G
T
C
A
C
A
C
C
T
G
A
G
G
A
T
G
T
20850
G
G
A
A
G
T
G
C
C
T
G
G
G
G
T
T
C
C
C
G
G
G
A
A
G
T
GGAG GATGTCCTGG GCCACTGGGA
20900
GAGGCGGCAC ATCCCCTGGG GGGC
T
GAGGT GGGGGAGGTG AGAAGCCAGG
20950 |
var(20925):[G:0.19]
CAGGGGCCAG GAAGTGGAAG CTTCAGGAGG ATGTGTGCAG GTCAAAGTGT
21000
AGGAGTCTGC ATCTTGAATG ATGCAGAGAG GGCCTCCAAG GCTCCAGTGT
21050
GCTGCAGGTG GGCAGAGGGG GCATGGGAAG TAGGGGTTGG CCCT
G
GGCAG
21100 |
var(21095):[T:0.02]
GGGTGGGGAG TGGGCCAGGC TGCCCAGCGG GGCTGAGCCT AGAGATGGAA
21150
GGGGCAGGGA CAAAGATGTG CAGCTGCCAG TCCTTGGAAA AGCTGAACGC
21200
CTGGTACTTC AGAGAACAAA AGGGTGGTTC TGAAGGCTGC TCCCAGGACA
21250
GTGGGGCTCC GAGGGTGCAA CCCCAAGGCT CACTCCTCCC AGTGCCCCCA
21300
ACGCGGCTCA GTCCTGTGTC TCTGCCTGTA GAGTTTCTTT GTTCCCTCTT
21350
CCTTCCTGGT GTTTTTCTCT CCCGCTCTCC AAATGCATAG GAGAAGTAAT
21400
TTGAAGTATC TCCAGAAAAA AAAAGAGAAA AAGAAAAAGA ATTGATTTCT
21450
TGTACTCCTA AA
T
C
C
T
A
A
A
A GTGTTTTTCT CGTTGCTAG
A
G
A
T
A
T
T
A
A
C
T
21500 |
var(21463):[:0.13]
| Exon 7
E I L T 209
C
C
A
C
C
C
A
A
C
A
T
G
A
C
T
G
C
A
A
A
G
T
G
T
A
A
T
A
A
G
A
C
A
C
A
T
T
C
C
T
T
T
A
T
G
C
A
C
T
G
21550
P P N M T A K C N K T H S F M H W 226
G
A
A
A
A
T
G
A
G
A
A
G
T
C
A
T
T
T
C
A
A
T
C
G
C
A
A
A
T
T
T
C
G
C
T
A
T
G
A
G
C
T
T
C
A
G
A
T
A
C
21600
K M R S H F N R K F R Y E L Q I 242
A
A
A
A
G
GTAAA CTTTCACCCC GCCCCCAGCC CCCCCACCCC CGTGGACATC
21650
Q K 244
CCTTATTTTT GGTAAGTCGC ACTCTG
G
GGC CTTGAA
A
C
G
G
G
C
A
A
C
A
A
T
C
T
21700 |
var(21677):[T:0.01]
|
NOT SCANNED
C
C
T
C
T
G
A
T
A
A
C
G
T
C
A
C
A
G
A
A
G
G
C
A
T
G
G
A
T
C
A
T
T
A
A
A
A
A
A
C
A
A
A
A
A
C
A
A
A
A
21750
A
C
A
A
A
A
G
G
C
C
G
G
G
C
G
C
T
G
T
G
G
C
T
C
A
C
G
C
C
T
G
T
C
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
21800 |
REPEAT
G
G
C
T
G
A
G
G
C
A
G
G
T
G
G
A
T
C
A
C
A
A
G
G
T
C
A
G
G
A
G
A
T
C
G
A
G
A
C
C
A
T
C
C
T
G
G
C
T
A
21850
A
C
G
C
G
G
T
G
A
A
A
C
C
C
C
G
T
C
T
C
T
A
C
T
A
A
A
A
A
T
A
C
G
A
A
A
A
A
A
A
A
T
T
A
G
C
T
G
G
G
21900
C
G
T
G
G
T
G
G
C
A
C
G
G
T
C
T
T
G
T
A
G
T
T
C
C
A
G
C
T
A
C
T
G
G
G
G
A
G
G
C
C
G
A
G
G
C
A
G
G
A
21950
G
A
A
T
T
G
C
T
T
G
A
A
C
C
C
A
G
G
A
G
G
T
G
G
G
G
G
T
T
G
C
A
G
T
G
A
G
C
C
G
A
G
A
T
C
G
C
G
C
C
22000
A
T
T
G
C
A
C
T
C
C
A
G
C
C
T
G
G
G
C
G
A
C
A
G
A
G
C
G
A
G
A
C
T
C
C
G
T
C
T
C
A
A
A
A
A
A
A
A
A
A
22050
A
A
A
C
AGTTTG AGACTGTATG TGGTCTGTTG TTTTTTATTT TTATTATTTC
22100 |
var(22054):[A:0.43]
TATTGTTATG TGGTTTTTTA ATTTTTTCTT GAACTTTCTT TTTTCTTTTG
22150
TAGTGATCTA CAGATTCAAT GCAAGCTTCC CAGATATTTT TGATCCACAG
22200
TTCGTTGGAT CAGTTGAACA TAAATATTGA
T
T
T
A
T
T
T
A
T
T
G
A
G
C
C
A
C
T
C
T
22250 |
REPEAT
G
G
C
T
C
T
G
T
A
G
C
C
C
A
G
G
C
T
G
G
A
G
T
G
C
A
G
T
G
A
C
T
T
A
A
A
T
C
T
T
G
A
C
T
C
A
C
T
G
C
22300 |
var(22266):[A:0.18]
|
var(22280):[G:0.18]
A
A
C
C
T
C
T
G
C
C
T
C
C
C
G
G
G
T
T
C
A
A
G
T
G
A
T
T
C
T
C
C
T
G
C
C
T
C
A
G
C
C
T
C
C
C
G
A
G
T
22350
A
G
C
T
G
G
G
A
T
T
A
T
G
G
G
C
A
C
C
C
A
T
C
A
C
C
A
C
A
C
C
C
A
G
C
T
A
A
G
T
T
T
T
T
G
T
A
T
T
T
22400
T
T
A
G
T
A
G
A
A
A
C
A
G
A
G
T
T
T
C
A
T
C
A
T
G
T
T
G
G
C
C
A
G
G
C
T
G
G
T
C
T
C
A
A
A
C
T
C
C
T
22450
G
A
C
C
T
C
A
G
G
T
G
A
T
C
C
A
C
C
C
G
C
C
T
C
G
G
C
C
T
C
C
C
A
A
A
G
T
G
C
T
G
G
G
A
T
T
A
C
A
G
22500
G
T
G
T
G
A
G
C
C
T
T
C
G
T
G
C
G
C
A
G
C
C
TATGTGTT ATATTTAGTT TG
T
A
T
T
T
T
A
T
22550 |
REPEAT
T
T
T
A
T
T
G
T
A
T
T
T
T
A
T
T
A
T
T
T
A
T
T
T
A
T
T
T
A
T
T
T
T
T
G
A
G
A
C
G
G
A
G
T
C
C
T
G
C
T
22600 |
var(22579):[:0.02]
C
T
G
T
C
A
C
C
C
A
A
G
C
TGTTTGT TTGTTTGTTT GTTTGTTTAT TA
T
T
T
T
T
G
A
G
22650 |
REPEAT
A
C
G
G
A
G
T
C
C
T
G
C
T
C
T
G
T
T
G
C
C
C
A
G
G
C
T
G
G
G
G
T
G
C
A
G
T
G
G
C
A
T
G
A
T
C
T
C
A
G
22700
C
T
C
A
C
T
G
T
A
A
C
C
T
C
C
G
C
C
T
C
T
C
G
G
G
T
T
C
A
A
C
C
A
A
T
T
C
T
C
A
G
C
T
T
C
A
G
C
C
T
22750
C
C
T
G
A
G
T
A
G
C
T
G
G
A
A
T
T
A
C
A
G
G
C
A
C
C
T
G
C
C
A
C
C
A
T
G
C
C
T
G
G
C
T
A
A
T
T
T
T
T
22800
T
T
T
T
G
T
A
T
T
T
T
T
A
G
T
A
G
A
G
A
T
G
G
G
G
T
T
T
C
A
C
C
A
T
C
T
T
G
T
C
C
C
G
G
C
T
G
G
T
C
22850
T
T
G
A
A
C
T
C
C
T
G
A
C
C
T
C
A
T
G
A
T
C
C
A
C
C
C
G
C
C
T
C
A
G
C
T
T
C
C
C
A
A
A
G
T
G
C
T
G
G
22900 |
var(22860):[C:0.13]
G
A
T
T
A
C
A
G
G
C
G
T
G
A
G
G
C
A
C
T
G
T
G
C
C
C
C
G
C
C
ATATATTTAT TATTTAT
A
CT
22950 |
var(22948):[G:0.34]
CAAATACTAA T
T
A
T
T
T
C
A
T
A
T
G
C
A
A
T
T
T
T
T
C
T
G
T
A
A
G
T
C
T
A
A
A
T
C
T
G
C
T
A
23000 |
REPEAT
A
A
A
A
A
C
G
T
T
A
G
G
T
C
T
A
T
T
A
A
T
T
T
C
T
T
TTAT ATTACCAAGT GTTTTTTAGC
23050
CAATCTGTTT GGGTTTTTTT TTTTTTTAAG AAAATAAAT
G
G
C
T
G
G
G
T
G
C
A
23100 |
REPEAT
G
T
A
G
C
T
T
A
C
G
C
C
T
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
C
G
A
G
G
C
A
G
G
A
C
G
A
T
23150
C
A
C
G
A
G
G
T
C
A
G
G
A
G
A
T
A
G
A
G
A
C
C
A
T
C
C
T
G
G
C
T
A
A
C
A
T
G
G
T
A
A
A
A
C
C
C
C
G
T
23200
C
T
C
T
A
C
T
A
A
A
A
A
T
A
C
A
A
A
A
A
A
A
A
A
T
T
A
G
C
T
G
G
G
C
G
T
G
G
T
G
G
C
G
G
G
C
G
C
C
T
23250
G
T
A
G
T
C
C
C
A
G
C
T
A
C
T
T
G
G
G
A
G
G
C
T
G
A
G
G
C
A
G
G
A
G
A
A
T
G
G
C
G
T
A
A
A
C
C
C
A
G
23300
A
A
G
G
C
G
G
A
G
C
T
T
G
C
A
G
C
G
A
G
C
T
G
A
G
A
T
T
G
T
G
C
C
A
C
T
G
C
A
C
T
C
C
A
T
C
C
T
G
G
23350
G
C
A
A
C
A
G
A
G
T
G
A
G
A
C
T
C
C
G
T
C
T
C
A
G
G
A
G
A
A
A
A
A
A
A
A
A
A
A
A
A
G
A
A
A
A
T
A
A
A
23400 |
var(23368):[T:0.01]
TACAGCACAG ACTTCTTTCT TTCACTGATT TGAGGGAGCA GGCATAGCTG
23450
CAGCCACAGG CAGAGTCGTA GCTAGTCTGA TGTTGCACCC CCTACCTAGT
23500
TCGCTGGCCT GGCATAGGCT GTCTGTGGCT ACCCCTGAGT GCATCTGGAC
23550
ACAGTCTGGG AGGAC
G
GTGG GTCTTGTTTG TCCACCGGCC TCACAAAGCC
23600 |
var(23566):[A:0.01]
CCCTCCCACC AAGGTCTTGC CACAGTGGCC CATAAGAAAC CTTTTG
G
G
C
C
23650 |
REPEAT
A
G
G
C
G
C
G
A
T
G
G
G
G
C
A
T
G
C
C
T
G
T
A
A
T
C
C
C
A
G
C
A
C
T
T
T
G
G
G
A
G
G
C
C
G
A
G
G
T
G
23700 |
var(23651):[G:0.07]
G
G
C
A
G
A
T
C
A
T
G
A
G
G
T
C
A
A
G
A
G
A
T
C
A
A
G
A
C
C
A
T
C
C
T
G
G
C
C
A
A
C
A
T
G
G
T
G
A
A
23750
A
C
T
T
T
G
T
T
T
C
C
A
C
T
A
A
A
A
A
T
A
C
A
A
A
A
A
A
T
T
A
G
C
C
A
G
G
C
G
T
G
G
T
G
G
C
A
C
G
C
23800
A
C
C
T
G
T
A
G
T
C
C
C
A
G
C
T
A
C
T
C
G
G
G
A
G
A
C
T
G
A
G
G
C
A
A
A
A
G
A
A
T
C
A
C
T
T
G
A
A
T
23850
C
C
G
G
G
A
G
G
C
G
G
A
G
G
T
T
G
C
A
G
T
G
A
G
C
C
G
A
G
A
T
C
A
C
G
C
C
A
C
T
G
C
A
T
T
C
C
A
G
C
23900 |
var(23859):[T:0.06]
C
T
G
G
G
T
G
A
C
G
G
A
G
T
G
A
G
A
C
T
C
C
G
T
C
T
C
A
T
A
A
A
T
A
A
A
T
A
A
A
C
A
A
A
C
A
A
A
CC
23950 |
var(23910):[A:0.04]
TTTTGGTCAG GTGCTATTTA CTCCTAAGCT CATTATTTTG CCCCCACTGC
24000
TGCCCGAAGG CCTTCCCAGA GCCCTCACTG TTTTGCTGGT TTTCCTGGAG
24050
GGAGAAATTT GAGTTTGGGA GGAGGAGGCT TTCAGGGACG GTCCAGACAC
24100
TCAAAAGTTT GCTTGCTTTT GTGTTGCAG
A
G
A
A
T
G
C
A
G
C
C
T
G
T
A
A
T
C
A
C
A
24150 | Exon 8
R M Q P V I T 251
G
A
A
C
A
G
GTGA GTGTTCCCTA CCCCCAGCCG CTGTACTTGA CATTGCAAAG
24200
E Q 253
GGTGAGTTTT ATTATTATTA AGAATAAAAT GATAAAAAAT ATTAATAATT
24250
CTTA
T
T
A
A
T
A
A
A
A
T
A
A
T
G
A
A
A
A
T
A
T
T
A
T
T
A
A
T
A
A
T
A
A
A
T
G
T
T
A
T
T
A
T
T
C
A
24300 |
NOT SCANNED
A
T
G
T
T
C
A
G
T
G
A
C
T
T
T
C
A
T
T
G
G
A
C
A
G
A
C
T
C
T
T
G
A
G
T
G
T
C
A
C
C
C
T
T
A
C
T
G
C
G
24350
A
T
C
T
T
G
C
A
A
A
A
T
T
G
G
G
A
T
A
T
T
T
C
A
C
A
T
C
C
C
C
A
A
A
T
T
G
A
G
G
G
A
T
G
G
G
A
A
A
A
24400
G
G
A
A
G
A
G
T
C
A
G
G
G
A
T
G
A
C
A
C
C
T
C
C
C
A
AGGT GTGAGAGCCA GATGCTATGG
24450
CTGGCCAGGT GCTGTCCAAA
C
GAGGTCCAC CCATTTGCCC CAGATTCCTT
24500 |
var(24471):[T:0.02]
ACCCTGGGCC AGGCAGCCCC AGTCCAGCAG GAACAAGCTA CCAAACCATA
24550
GCTCCACCCA GCAGAGACAA GCATTCAGAC AGGTGGCCCA GACCTCAGAC
24600
AGAGGACCCT CCCCCAGCCC CTGCCTGGGA TCTGCAGGAA CAGACAGCCG
24650
GACCACAGCA TTCTCTGTCC CCTCTCTCTC TGTCCATCTC TTTCCCCGTA
24700
TCTCTTTCTC TGTCTCTGAA TCTCTCTG
C
C
T
T
T
C
T
C
C
C
T
C
C
C
T
C
T
C
T
T
T
C
24750 |
NOT SCANNED
T
C
T
C
T
C
T
C
T
C
G
T
C
T
C
T
A
T
C
T
C
C
C
T
C
C
C
C
C
T
C
T
C
T
G
T
A
T
C
T
C
C
C
T
C
C
C
T
T
T
24800
T
T
C
C
C
T
C
C
C
T
C
T
A
T
C
T
T
T
C
T
G
G
C
T
C
T
C
T
C
C
C
T
G
T
G
T
C
T
A
T
C
T
C
T
C
C
C
T
G
T
24850
C
C
C
C
A
T
C
T
C
T
C
T
C
T
G
T
G
T
C
T
C
T
T
T
C
C
C
T
C
C
C
T
C
T
C
T
C
A
T
T
C
T
C
C
T
T
C
C
C
T
24900
C
T
C
T
C
T
A
T
C
T
T
T
C
T
C
T
C
C
C
T
G
T
C
T
C
T
A
T
C
T
C
C
C
G
C
T
C
C
G
T
G
T
C
T
G
T
C
T
C
T
24950
A
T
C
T
T
T
C
T
C
C
C
T
T
T
C
T
C
C
C
T
C
C
A
T
C
T
C
T
C
T
C
T
C
C
C
T
G
T
C
T
C
T
C
T
C
T
C
C
C
C
25000
G
T
T
C
C
C
A
T
C
T
C
T
C
T
C
T
C
T
G
T
G
T
C
T
C
T
G
T
C
T
C
T
C
C
C
T
C
T
C
T
C
A
T
T
C
T
C
C
C
T
25050
C
C
C
T
C
T
T
T
T
A
T
T
C
T
C
C
C
T
C
C
C
T
C
T
C
T
T
T
C
T
C
T
C
T
C
T
C
T
C
T
C
T
C
T
C
T
C
C
T
G
25100
G
T
C
T
C
T
G
T
C
T
C
C
C
C
C
C
T
C
C
C
C
A
T
C
T
C
T
T
T
C
T
C
T
G
T
G
T
C
T
G
T
C
T
C
T
G
T
A
A
C
25150
C
T
T
C
T
C
C
A
T
T
T
C
T
C
C
C
T
C
C
A
T
C
T
C
T
C
T
G
T
C
T
C
T
C
C
C
T
G
T
G
T
C
T
A
T
C
T
C
C
C
25200
A
C
T
G
T
C
C
C
T
G
T
C
T
G
T
T
T
C
T
C
C
G
T
G
T
C
T
G
T
C
T
C
T
G
T
A
T
C
T
C
T
C
T
C
C
C
T
T
T
C
25250
T
C
C
C
T
C
C
A
T
C
T
T
T
C
T
C
T
C
T
C
T
C
C
C
C
C
G
G
T
C
T
C
T
A
T
C
T
T
C
C
C
T
T
C
T
C
C
C
C
A
25300
T
C
T
C
T
C
T
C
T
C
T
C
T
G
T
C
T
G
T
C
T
C
T
G
T
A
T
C
T
C
T
C
T
C
C
C
T
T
T
C
T
C
C
C
T
C
C
A
T
C
25350
T
T
T
C
T
C
T
C
T
C
T
C
T
C
C
C
G
G
T
C
T
C
T
A
T
C
T
C
C
C
C
C
T
C
T
C
C
C
C
G
T
C
T
C
T
T
T
C
T
C
25400
C
G
T
G
T
C
T
G
T
C
T
C
T
G
T
G
T
C
T
C
T
C
T
C
C
C
T
T
T
C
T
C
C
C
T
C
C
C
T
C
C
A
T
C
T
T
T
C
T
C
25450
T
C
T
C
T
C
T
C
C
C
G
G
T
C
T
C
T
A
T
T
T
C
C
T
C
C
C
T
C
C
C
C
A
T
C
T
C
T
T
T
C
T
C
T
G
T
G
T
C
T
25500
G
T
C
T
C
T
G
T
A
T
C
T
C
T
C
T
C
C
C
T
T
T
C
T
C
C
C
T
C
C
A
T
C
T
T
T
C
T
C
T
C
T
C
T
C
T
C
C
T
G
25550
G
T
C
T
C
T
A
T
C
T
C
C
C
C
C
T
C
T
C
C
C
T
G
T
C
T
C
T
C
T
G
T
G
T
C
T
G
T
C
T
C
T
G
T
A
T
C
T
C
T
25600
C
T
C
C
C
T
T
T
C
T
C
C
C
T
C
C
C
T
C
T
C
T
T
T
A
T
C
T
C
T
C
T
C
T
C
T
C
T
C
T
C
T
G
C
C
T
C
T
A
T
25650
C
T
C
C
C
A
C
T
G
T
C
C
A
A
A
T
C
T
G
T
G
T
C
T
C
T
G
T
C
T
C
T
C
C
C
T
C
T
T
T
C
A
T
T
C
T
C
C
C
T
25700
C
T
C
T
T
T
C
T
C
T
A
T
C
T
C
T
C
T
C
C
T
T
G
T
C
T
A
T
A
T
C
T
C
C
C
C
C
T
C
T
C
C
C
A
G
T
C
T
C
T
25750
C
T
G
T
A
T
C
T
C
T
G
T
A
T
C
T
C
T
C
T
C
C
C
T
T
T
C
T
C
C
T
T
C
C
C
T
C
T
C
T
T
C
A
T
C
T
T
T
C
T
25800 |
REPEAT
T
T
T
T
G
A
A
A
C
G
G
A
G
T
T
T
T
T
C
T
C
T
T
G
T
T
G
C
C
C
A
G
G
C
T
G
G
A
G
T
G
C
G
A
T
G
G
C
A
C
25850
G
A
T
C
T
C
G
G
C
T
C
A
C
T
G
C
A
A
C
C
T
C
C
G
C
C
T
C
C
C
A
G
G
T
T
C
A
A
G
C
G
A
A
T
C
T
A
C
T
C
25900
C
C
T
C
A
G
C
C
T
C
C
C
A
A
G
T
A
G
C
T
G
G
G
A
T
T
A
C
A
G
G
C
A
C
T
C
G
C
C
A
C
C
A
T
G
C
C
C
A
A
25950
C
T
A
A
C
T
T
T
T
T
T
T
T
T
T
T
T
T
T
G
T
A
T
T
T
T
T
A
G
T
A
G
A
G
A
C
A
G
G
G
T
T
T
C
A
C
T
A
G
T
26000
G
G
G
C
C
A
G
G
C
T
G
G
T
C
T
C
G
A
A
C
T
C
C
T
G
A
C
C
T
C
A
G
G
C
G
A
T
C
C
A
C
C
T
G
C
C
T
C
A
T
26050
C
C
T
C
T
C
A
A
A
G
T
G
C
T
G
G
A
A
T
T
A
C
A
G
G
T
G
T
G
A
G
C
C
A
C
C
G
T
G
C
C
C
G
G
C
C
C
C
T
C
26100
T
C
T
T
T
A
T
C
T
T
T
C
T
A
G
C
T
C
T
C
T
C
C
C
T
G
T
C
T
C
T
C
T
C
T
C
C
C
T
T
C
C
C
C
T
C
T
C
T
G
26150
T
C
T
C
T
C
T
C
T
C
C
C
T
T
C