LOCUS CKM 20454 bp DNA linear PRI 29-MAR-2004 DEFINITION Homo sapiens. ACCESSION CKM VERSION tmp KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 20454) AUTHORS Rieder,M.J., Daniels,R.L., da Ponte,S.H., Hastings,N.C., Ahearn,M.O., Rajkumar,N., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (29-MAR-2004) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI HL66682 Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu). FEATURES Location/Qualifiers source 1..20454 /organism="Homo sapiens" /db_xref="taxon:9606" repeat_region 1..143 /rpt_family="Alu" /rpt_type=dispersed repeat_region 153..447 /rpt_family="L2" /rpt_type=dispersed variation 209..211 /frequency="0.98" /replace="" variation 275 /frequency="0.14" /replace="G" variation 363 /frequency="0.03" /replace="A" variation 757..759 /frequency="0.01" /replace="" variation 944 /frequency="0.03" /replace="T" variation 990 /frequency="0.03" /replace="A" gene 2004..18468 /gene="CKM" mRNA join(2004..2059,5149..5359,6902..7056,9284..9416, 12961..13132,16349..16472,17231..17420,17953..18468) /gene="CKM" /product="CKM" variation 2190 /gene="CKM" /frequency="0.02" /replace="T" variation 2312 /gene="CKM" /frequency="0.02" /replace="A" variation 2512 /gene="CKM" /frequency="0.42" /replace="T" variation 2658 /gene="CKM" /frequency="0.48" /replace="G" variation 2724 /gene="CKM" /frequency="0.15" /replace="A" variation 2955 /gene="CKM" /frequency="0.01" /replace="G" variation 3118 /gene="CKM" /frequency="0.02" /replace="A" repeat_region 3122..3246 /rpt_family="Alu" /rpt_type=dispersed variation 3247 /gene="CKM" /frequency="0.02" /replace="A" repeat_region 3297..3504 /rpt_family="MIR" /rpt_type=dispersed variation 3543 /gene="CKM" /frequency="0.02" /replace="C" variation 3657 /gene="CKM" /frequency="0.01" /replace="T" repeat_region 3677..3989 /rpt_family="Alu" /rpt_type=dispersed variation 3871 /gene="CKM" /frequency="0.01" /replace="G" variation 3920 /gene="CKM" /frequency="0.47" /replace="T" variation 3934 /gene="CKM" /frequency="0.34" /replace="T" repeat_region 4005..4230 /rpt_family="MIR" /rpt_type=dispersed variation 4074 /gene="CKM" /frequency="0.02" /replace="T" repeat_region 4261..4367 /rpt_family="MIR" /rpt_type=dispersed repeat_region 4368..4425 /rpt_family="MIR" /rpt_type=dispersed variation 4457 /gene="CKM" /frequency="0.01" /replace="G" variation 4475 /gene="CKM" /frequency="0.43" /replace="T" repeat_region 4484..4791 /rpt_family="Alu" /rpt_type=dispersed variation 4648 /gene="CKM" /frequency="0.02" /replace="T" variation 4762..4765 /gene="CKM" /frequency="0.01" /replace="" repeat_region 4792..5101 /rpt_family="Alu" /rpt_type=dispersed variation 4964 /gene="CKM" /frequency="0.24" /replace="C" variation 5132 /gene="CKM" /frequency="0.02" /replace="T" CDS join(5167..5359,6902..7056,9284..9416,12961..13132, 16349..16472,17231..17420,17953..18131) /gene="CKM" /codon_start=1 /product="CKM: creatine kinase, muscle" /translation="MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRD KETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKP TDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVE ALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIW HNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQH LGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVF DVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK" variation 5418 /gene="CKM" /frequency="0.02" /replace="T" variation 5437 /gene="CKM" /frequency="0.02" /replace="T" variation 5446 /gene="CKM" /frequency="0.01" /replace="T" repeat_region 5454..5561 /rpt_family="MIR" /rpt_type=dispersed repeat_region 5574..5711 /rpt_family="MIR" /rpt_type=dispersed variation 5643 /gene="CKM" /frequency="0.01" /replace="T" repeat_region 5725..6020 /rpt_family="Alu" /rpt_type=dispersed repeat_region 6074..6193 /rpt_family="MIR" /rpt_type=dispersed variation 6091 /gene="CKM" /frequency="0.01" /replace="C" variation 6140 /gene="CKM" /frequency="0.03" /replace="A" variation 6355 /gene="CKM" /frequency="0.01" /replace="A" repeat_region 6449..6755 /rpt_family="Alu" /rpt_type=dispersed variation 6956 /gene="CKM" /frequency="0.01" /replace="G" variation 7044 /gene="CKM" /frequency="0.01" /replace="C" repeat_region 7195..7291 /rpt_family="Alu" /rpt_type=dispersed variation 7212 /gene="CKM" /frequency="0.34" /replace="T" repeat_region 7292..7607 /rpt_family="Alu" /rpt_type=dispersed variation 7531 /gene="CKM" /frequency="0.01" /replace="A" variation 7599 /gene="CKM" /frequency="0.28" /replace="T" repeat_region 7608..7780 /rpt_family="Alu" /rpt_type=dispersed repeat_region 7897..8108 /rpt_family="Alu" /rpt_type=dispersed variation 7901 /gene="CKM" /frequency="0.08" /replace="C" variation 7917 /gene="CKM" /frequency="0.23" /replace="C" variation 7975 /gene="CKM" /frequency="0.04" /replace="A" variation 7995 /gene="CKM" /frequency="0.06" /replace="A" variation 8013 /gene="CKM" /frequency="0.23" /replace="C" variation 8043 /gene="CKM" /frequency="0.36" /replace="G" repeat_region 8265..8402 /rpt_family="Alu" /rpt_type=dispersed repeat_region 8418..8535 /rpt_family="Alu" /rpt_type=dispersed misc_feature 8475..8634 /gene="CKM" /note="Region not scanned for variation" repeat_region 8536..8833 /rpt_family="Alu" /rpt_type=dispersed repeat_region 8834..9041 /rpt_family="Alu" /rpt_type=dispersed variation 9304 /gene="CKM" /frequency="0.44" /replace="C" variation 9314 /gene="CKM" /frequency="0.01" /replace="G" variation 9511 /gene="CKM" /frequency="0.43" /replace="C" variation 9558 /gene="CKM" /frequency="0.05" /replace="T" variation 9612 /gene="CKM" /frequency="0.36" /replace="T" variation 9613 /gene="CKM" /frequency="0.30" /replace="T" repeat_region 9880..10168 /rpt_family="Alu" /rpt_type=dispersed misc_feature 9890..11364 /gene="CKM" /note="Region not scanned for variation" repeat_region 10169..10459 /rpt_family="Alu" /rpt_type=dispersed repeat_region 10460..10686 /rpt_family="MER2_type" /rpt_type=dispersed repeat_region 10838..11001 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11025..11316 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11322..11782 /rpt_family="MER2_type" /rpt_type=dispersed variation 11592 /gene="CKM" /frequency="0.21" /replace="A" variation 11610 /gene="CKM" /frequency="0.06" /replace="C" variation 11669 /gene="CKM" /frequency="0.05" /replace="G" variation 11687 /gene="CKM" /frequency="0.02" /replace="C" repeat_region 11906..12209 /rpt_family="Alu" /rpt_type=dispersed repeat_region 12259..12461 /rpt_family="Alu" /rpt_type=dispersed repeat_region 12464..12572 /rpt_family="Alu" /rpt_type=dispersed variation 12564 /gene="CKM" /frequency="0.02" /replace="A" repeat_region 12679..12855 /rpt_family="L2" /rpt_type=dispersed variation 12891 /gene="CKM" /frequency="0.41" /replace="A" variation 13106 /gene="CKM" /frequency="0.05" /replace="A" variation 13192 /gene="CKM" /frequency="0.06" /replace="A" variation 13231 /gene="CKM" /frequency="0.45" /replace="G" variation 13275 /gene="CKM" /frequency="0.03" /replace="T" variation 13279 /gene="CKM" /frequency="0.43" /replace="A" repeat_region 13356..13654 /rpt_family="Alu" /rpt_type=dispersed misc_feature 13508..14092 /gene="CKM" /note="Region not scanned for variation" repeat_region 13664..13801 /rpt_family="Alu" /rpt_type=dispersed repeat_region 13802..14119 /rpt_family="Alu" /rpt_type=dispersed repeat_region 14120..14254 /rpt_family="Alu" /rpt_type=dispersed variation 14170 /gene="CKM" /frequency="0.01" /replace="T" variation 14216 /gene="CKM" /frequency="0.05" /replace="A" repeat_region 14257..14461 /rpt_family="MIR" /rpt_type=dispersed repeat_region 14462..14764 /rpt_family="Alu" /rpt_type=dispersed variation 14509 /gene="CKM" /frequency="0.03" /replace="T" variation 14510 /gene="CKM" /frequency="0.03" /replace="G" repeat_region 14765..14808 /rpt_family="MIR" /rpt_type=dispersed repeat_region 14998..15301 /rpt_family="Alu" /rpt_type=dispersed repeat_region 15307..15608 /rpt_family="Alu" /rpt_type=dispersed misc_feature 15325..15667 /gene="CKM" /note="Region not scanned for variation" repeat_region 15626..15935 /rpt_family="Alu" /rpt_type=dispersed variation 15785 /gene="CKM" /frequency="0.18" /replace="A" variation 16001 /gene="CKM" /frequency="0.01" /replace="A" variation 16038 /gene="CKM" /frequency="0.02" /replace="A" variation 16078 /gene="CKM" /frequency="0.01" /replace="" variation 16423 /gene="CKM" /frequency="0.01" /replace="C" variation 16632 /gene="CKM" /frequency="0.16" /replace="" repeat_region 16721..17014 /rpt_family="Alu" /rpt_type=dispersed variation 16834 /gene="CKM" /frequency="0.01" /replace="C" repeat_region 17521..17640 /rpt_family="MIR" /rpt_type=dispersed repeat_region 17630..17698 /rpt_family="MIR" /rpt_type=dispersed repeat_region 17691..17753 /rpt_family="MIR" /rpt_type=dispersed variation 18104 /gene="CKM" /frequency="0.29" /replace="T" variation 18253 /gene="CKM" /frequency="0.01" /replace="C" variation 18389 /gene="CKM" /frequency="0.07" /replace="C" variation 18795 /frequency="0.03" /replace="T" variation 18874 /frequency="0.01" /replace="A" variation 18931 /frequency="0.45" /replace="G" variation 19112 /frequency="0.02" /replace="T" variation 19346 /frequency="0.06" /replace="G" repeat_region 19440..19517 /rpt_family="MIR" /rpt_type=dispersed variation 19501 /frequency="0.01" /replace="C" variation 19997 /frequency="0.27" /replace="A" repeat_region 20028..20272 /rpt_family="L2" /rpt_type=dispersed variation 20194 /frequency="0.16" /replace="T" variation 20208 /frequency="0.40" /replace="G" BASE COUNT 4857 a 5633 c 5341 g 4623 t ORIGIN 1 ctaatttttg tacttttagt agagatgggg tttcaccatg ttggccaggc tggtcttgaa 61 ctcctggcct caagtgatcc acccgcctcc gcctctgcct cccaaagtgc tgggattacg 121 ggcctgagcc actgtgcccg gcccatctaa cattttcact gtcaatcaca atgggattaa 181 aactcctccc acagccccta gggcaccacc atgggtctgc tcctgtctcc cctccaacct 241 catcttcttc ctcccactct ctccttggcc ccatctgctc cagtcccctg gcctccttcc 301 tgtctgtcct cagatgtgcc cagccattct cacctcagcg cctttgcacc tgctgttccc 361 cccagagccg cacatggctg gctccctgtt ctccttcagg tctctgctca gatgtcatct 421 tcccaaagag gcctgcctcg acctcccctg ctgctgtgcc gtcccctcat ctgtgaccct 481 cttgcactat cacctccagg acggcggggg ttttgtgttt tgttgtagcc tcaggaagtg 541 cctgatagat ccctgtttcg agaccagttc catttggttt tctgggcctc agtttccgta 601 accgtgaagg agaccctcgg caatctgagc ttgctgggaa agggctgggc cccatgtaaa 661 tatttctaaa gcacccctct cccctccccc ctcagatcag gagtctgagg gagaggcaca 721 gaggctccct ttctctaagc cagtcctcac ctgcctaaga agatgtgaag gagacccagg 781 agaccctggg atagggagga actcagaggg aagggacatt cttttcttcg tcgcaatcct 841 gggagctccc tggaggagga gacccgatca gcctgcaatc ctggcgcgtc ccaggaggag 901 aaagcggctt cctctatact gtactctcct ccacagaacc cccctctcag ccctggaagt 961 ccttgctcac agccgaggcg ccgagagcgc ttgctctgcc cagatctgcg cgagtctggc 1021 gcccgcgctc tgaacggcgt cgctgcccag cccccttccc cgggaggtgg gagcggccac 1081 ccagggcccc gtggctgccc ttgtaaggag gcgaggcccg aggacacccg agacgcccgg 1141 ttataattaa ccaggacacg tggcgaaccc ccctccaaca cctgcccccg aaccccccca 1201 tacccagcgc ctcgggtctc ggcctttgcg gcagaggaga cagcaaagcg ccctctaaaa 1261 ataactcctt tcccggcgac cgagaccctc cctgtccccc gcacagcgga aatctcccag 1321 tggcaccgag ggggcgaggg ttaagtgggg gggagggtga ccaccgcctc ccacccttgc 1381 cctgagtttg aatctctcca actcagccag cctcagtttc ccctccactc agtccctagg 1441 aggaaggggc gcccaagcgc gggtttctgg ggttagactg ccctccattg caattggtcc 1501 ttctcccggc ctctgcttcc tccagctcac agggtatctg ctcctcctgg agccacacct 1561 tggttccccg aggtgccgct gggactcggg taggggtgag ggcccagggg gcacaggggg 1621 agccgagggc cacaggaagg gctggtggct gaaggagact caggggccag gggacggtgg 1681 cttctacgtg cttgggacgt tcccagccac cgtcccatgt tcccggcggg gggccagctg 1741 tccccaccgc cagcccaact cagcacttgg tcagggtatc agcttggtgg gggggcgtga 1801 gcccagcccc tggggcggct cagcccatac aaggccatgg ggctgggcgc aaagcatgcc 1861 tgggttcagg gtgggtatgg tgcgggagca gggaggtgag aggctcagct gccctccaga 1921 actcctccct ggggacaacc cctcccagcc aatagcacag cctaggtccc cctatataag 1981 gccacggctg ctggcccttc ctttgggtca gtgtcacctc caggatacag acagcccccc 2041 ttcagcccag cccagccagg tactgcacgg ggcgggaatc tgggtggggg ccagagtagg 2101 ggatttctgt gggtgctaga ggcttggctt gggaaagggt ctgtgtgtca ccccttgctc 2161 caccaacatc ctcctataca aaggcaggtc ggtgcgtggg aaggttgacc cttgtgtgtc 2221 tgggaggccc ctccatctgt gaggctgcct gaacccccca ctgggacctg tgatttctgc 2281 ggcacaagtc ttgggttatg gggagggatc cgagatgaaa ggggtcctga cagctgccaa 2341 ctgtcacccc ctgcaagggg ctgttgagcc aggcctgtgt tcattacagt ttgtcgccaa 2401 cactggcgcc acaagccgtg ggaggtgtgt ctgtcgccta gcagagtctg caagagcagg 2461 tgtcgcaggc tttctttgcg tttgctactg tgtgggtccc tgtgaccttg tatctgactt 2521 agtagcggac acatgagtgt cctgggcatg tccttgagtt tggaagtgtg actgtgtgac 2581 ttagtttaca gtgtgatctg gggagtctgc ggtggtgggg gtgtgtggct ctggggcttt 2641 ctgcttatgt ctcttgtcgg gggggtcacc accctgcctc agtgccctct cctggggtgt 2701 ccctggcagg gattaggggg gcatcctctg aagggagggg gtctgggctg ccatcccagg 2761 atgtccttga gccccgaggc ctggacccgt gtcctcccag ccaccctggc ccacctgtct 2821 tgggcctgct gacttggtgc aagccgagcc ccggaatgtg ggggtggggc ggggcagcag 2881 ctgggggtgg gatggcaggc agttgccaga ttctaaaaat aaccaccctg gacagcagca 2941 cccaaggtct ttggcgggtc cctgttcctc ttccctggct tcagctcacc gtggtcccaa 3001 tctccctccc acaatcccac ctgcttccca tccccgtctc ccaccgctgc tggaggcccc 3061 ttctcctttc tgggtccctt ctcctttctg ggtccagtga ataaaataat aataacagta 3121 ggacctggcg cagtggctca cacgcataat cccagcatct tgggaggccg atgctggagg 3181 atcacttgag gccaggagtc ccagaccagc ctgggcaaca tagtgagacc ccatctctgc 3241 aaaaaagtag taataacaaa taacaataat agcagccacc agggttccag gctccaactc 3301 catgccaggg cctgtgctca gccaacctca tggccaagct cagaggatcc tggcaatcct 3361 acggggcagg ctcagttcac aggagacaga ggtccagaga ggcctagtga ctggcctggg 3421 gtcacacagc agggaaatgg cataggtggg atttgaacct gcctctgacg acccagaggc 3481 tgagcttttc ttcccttctg agccctgtgg gagaactgtc agcaggcaga ggtgggggca 3541 gctacccagc cctcccccga cccagccctt tgtctttgga ttgataatcc aagaacctgc 3601 tcacatactc ccagcagcac cctcacctcc accttctcac cagctcctcg cacgaacctt 3661 taaaataaca acaacaggcc aggtgccgtg actcatgcct gtaatctcag cactttggga 3721 ggcagaggtg ggcggatcac ttgagttcag gagttcaaga ccagcctggc caacatggcg 3781 aaaccccaac tctactaaaa ataccaaaaa aaaaaatagc caggtgtggc acacgcctgt 3841 agttgcagct actcaggagg ctgaagcagg atagttgctt gaacctggga ggtggaggtt 3901 gcagtgaact gagattatgc cactgcactc tagcctgggc gacagagcga gactctgtct 3961 caaacataat aataataata ataataatag cagctaagtg aaataatgct tattgtgtac 4021 caggcactgt tccgagagct acacctgtat tcacacattt aatcttttca acactcccat 4081 gcggcaagtg ctgttaggat cctcattttc tagatgagta aattgaggca cagaggttaa 4141 gcaacttgcc cctggccaca cagctggttg taggtagcag agctgggaat caaaccctgg 4201 gctgattcca gaacctacac tcttacccac acaaaatatt tttccagcct ccgggagggg 4261 cccgttttcc acctggggaa attgagtttc cagcaagaat gactagtcca ggctcaccca 4321 actgggatac ggcagagcca ggcccttgat ctaagactcc ggatgccttc ctgctgagac 4381 acaggggctc agagagagga tttctcttgc tccaagttac acagcctgcc tgaccccaac 4441 gccttgccca gttctcttgc tgctgtctgc aagacgcgag ctaggcgggg cacagtggct 4501 cacgcctgta atcccagcac tttgggaggc cgaggcgggt ggatcacttg aggccaggag 4561 ttcgagacca gcctggccaa ccagtagaga tggtgaaacc ccatctctaa taaaaataca 4621 aaaaaattag ccaggcatgg tggtgtgcgc ctgtaatccc agctactcag gaggctgaga 4681 caggagaatc tcttgaacct gggaggtgga ggctgcagtg agccgaggtc tcgccactgc 4741 actccaacct gggtaacaga gtgagactcc atctcaaaaa aaagaagaaa aggccgggtg 4801 cagtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggcgg atcacaaggt 4861 caggagatca agactatcct ggctaacatg gtgaaacccc gtctctacta aaaatacaaa 4921 aaatgagccg gcgtggtggc gggcgcctgt attcccagct acttgggagg ctgaggcggg 4981 agaatggtgt gaacccagga ggtggagctt gcagtgagcc gagatcgtgc cactgcactc 5041 cagcctgggt gacagagcga gactccgtct caaaaaaaaa aaaagaagaa gaagaagaaa 5101 aaagatgcca gctaatcttc aatcttcccc tcctgccctg cccatcaggt ctcctacacc 5161 gccaccatgc cattcggtaa cacccacaac aagttcaagc tgaattacaa gcctgaggag 5221 gagtaccccg acctcagcaa acataacaac cacatggcca aggtactgac ccttgaactc 5281 tacaagaagc tgcgggacaa ggagactcca tctggcttca ctgtagacga tgtcatccag 5341 acaggagtgg acaacccagg tgagcctccc cagtggagca ctgaaggggc tacatggggg 5401 ctctggaggc tgccggccat gccccaatcc caccaccctt gaaggggggg ggggcctcag 5461 ttttctcatc tgtaaaatgg ggctgttgtg ggaatcaatg cattaatata cataaaggct 5521 tgggacagtg cgaggtactc agcaaaccac gcaataaaca tgcacgagaa taatgtgaga 5581 tccccaagga ggtcggttca cctcctgaac ctcagtctcc tcatctgaaa aatgggcgcc 5641 cacgttgtga aaacacaagt caatggctgt gcagtgctta gagtggcacc tggcaccaag 5701 tgagtgctca agctctgaca ggggggccag gtgcagtggc tcatgcctgt aatcccagca 5761 ctttgggagg cccaggtggg aggatcactt gaggccagga gtttgagacc agcctgagca 5821 acatagcaag accctgtctc tacaaaaaat acaaaaaaat tagccaagtg tggtgatgag 5881 ggcttgtggt ccaagctact caggaggctg cggtgggagg atcgcttgag cctgggaggt 5941 gcaggttgca gtaagccgag atcgcgccac tgtactccag ccacagagtg agaccctgtc 6001 tcaaaaaaaa aaaaaaagaa tctgacaggg gatgttatta atgttatggt tgtttctcaa 6061 aggacattgc aaggcgaaga gagctgggag tggaggggag gctctagtgc ccctcacatc 6121 cagctcactg tgtgatgccg gggagaagcc cctctctcct ggcccctgtt tttccactgg 6181 gaaacaagag ggtctttcaa gtctcttacc ctcctgaccc tctgtggtac ggtggtagcc 6241 tgagatccta acatttcagg ctaagatgtc atgactttgg gtgctaatgt ttccgaggtg 6301 ctgatgcttt tagcaccatg taccctctga agctcccctt tctcctttga ccccgccccc 6361 agcactcttt cttctctccc accttgaccc ctcccagcca ccttgacctc tcccagcctt 6421 ccctcccagt tcccaccagt cctcagtgtt ctctcttttt ttttttttcc tttggagaca 6481 gagtcttgct ctgtcaccca ggctggagtg cagtggtgtg atcttggctc actgcaacct 6541 ccactccctt ggttcaagca attctcatgc ctcagcctcc tgagtagctg ggattacagg 6601 tgtgtgcccc acacccagct aatttttgta tttttagcag agatggggtt tcaccctgtt 6661 ggccaggctg gtctcacact cctgacctca agagattcac ccgcctcacc ctcccaaagt 6721 gctgggattg caggcatgag ccactgtgcc caacccttat gattctcaat tcccacccag 6781 aggtattgaa tgtacccgcc cccatcccga cacacatgtc cacacaggct ccactgagcc 6841 cacaagccca cgccctgttt gctggggaca agcagctctg acctcacccc cacccctcca 6901 ggtcacccct tcatcatgac cgtgggctgc gtggctggtg atgaggagtc ctacgaagtt 6961 ttcaaggaac tctttgaccc catcatctcg gatcgccacg ggggctacaa acccactgac 7021 aagcacaaga ctgacctcaa ccatgaaaac ctcaaggtcg gtgtctgcgc aggaggggag 7081 ggccgagggg tgaggaggag agagatcaca ggagaaatgg ggggagacag agaaatacag 7141 agacagagag agacacagag gtgtggagaa gcagagagat ggaaagagag agggacattg 7201 ggaggctgag gcgagcgtat cacttgaggt caggagttca agaccagcct ggccaacatg 7261 gcaaaactct gtctttaaaa aaaaaaaaaa gggctgggca cggcggtggc tcacgcctgt 7321 aatcccagca ctttgggagg ccaaggcggg cagatcacct tagattgaga gtttgagacc 7381 agcctgacca acatggtgaa accccgtctc tactaaaaat acagaattag ctgggtgtgg 7441 tggcacatgc ctgtaatccc agctacgtgg gaggctgagg caggagaatc gcttgaacct 7501 ggaaggcaga ggttgtggtg agcagagatc gtgccattgc actccagcct gggcaacaag 7561 ggcgaaactc gtctcaaaaa ataaataaat aaataaataa aataaattag ctgggcatgg 7621 tggcgcgtgc ctgtaatccc agctactcag gaggtggagg caggaaaatc tcttgaaccc 7681 aggagatgga ggctgcagtg agctgagatc atgccactgc actccagcct gggtgacaga 7741 gcaagattct atctcagaaa ataaaaaaag gaaagagaga gggacagaga gacacagaga 7801 cagccaagga gacacagaca accaaggaga cagacagaca aaggagaggg agagggagaa 7861 gaaaggcaca aaagcatgta gaaaaggaag aggcatagcc gggcacagtg gctcacgctt 7921 gtaatcccaa cactttggga ggctgaggtg ggcggatcat aaggtcagga gttcgagacc 7981 agcctgacca acacggtgaa acccagtctc tattaaaaat acaaaaatta gctaggcatg 8041 ctagtgttca cctataatcc tagctattca gcctgggtga cagagcgaga ctctgcctaa 8101 aaaaaaaagg gtggggggag aggcagagac acagagggag acagaaggga gcatcagaga 8161 aggcaggaga gacagggaga gagagacaca cgcagttgca gtcagacaca gacaaggaga 8221 gtgggagaaa gggagacagg aagagaaaca gaaatgggca gaaaggctgg gtgcagtggc 8281 tatacctgta atcccagcac ttatggaggc tgaggtgtga ggatcacgtg aagccaggag 8341 agttcacgac cagcttgggc aacatagcaa gaacccgtct ctgcccaaaa aaaagaaaaa 8401 aaaaagccta aaaatttagc taggcatggt ggctcatgcc tgtaatccca tcacgttggg 8461 aggctgaggc aggaggactg tttgagccca ggagtttgag accagcctgg gcaacatagt 8521 gacaccctgt ctctattttt tttttttttt tgagacagaa tctcactctg tcacccaggt 8581 tggagtgcag tggctcgatc tcagctcacg gaaacccctg atccccaggt tcaagtgatt 8641 ctcgtgcctc agcctcctga gtagctggga ttacaggcgc gcaccaccac gcccagctaa 8701 tttttgtatt tttagtagaa atggggtttc accatgttgg ccaagctggt ttcgaactcc 8761 tgacctcagg tgattggctc acctcggctt cccaaagtgt tgggattaca ggtgtgagcc 8821 accgcgccca gcccctgtct ctatttataa aaaatttatt ttaagttagc cgaacatggt 8881 ggcatatacc tacctgttag tcccagctac ttgggaggct gaggcagggg aattgcttga 8941 gcccaggagt ttgaggttgc agtgagctat gatggcacca ctgcactcca gcctgggcga 9001 cagagagaga ccctgtctcg aagaaaaaaa aggaaaagaa atatacgaag atggggagag 9061 agaggtataa agaaaaacag agataggaga ggggagagag acagagaagg gagagacaga 9121 gcccaggtat gggtggcggg gagaggctcc acacacccaa tcagtgagga tgcagaaggc 9181 aaaggaagca acagggagac tgaggggagc atctggggga gacctgggct tgctggagag 9241 ggcggaggat ctgcctggtc ctgatctccc acccgctctc cagggtggag acgacctgga 9301 ccctaactac gtgctcagca gccgcgtccg cactggccgc agcatcaagg gctacacgtt 9361 gcccccacac tgctcccgtg gcgagcgccg ggcggtggag aagctctctg tggaaggtga 9421 gcgcccctac cccgtccact gctggggtca cccagccctg gctctgttcc tccatgggca 9481 ggtcctcggg tctctttggg cccccgcttt tcaaagtagg ggaagagctt ggtaaatcgt 9541 gggggcttgg ggaatggcgc gggctgtcag cattacctgc tgtgttggag attcagggat 9601 gctgtccaga cccgacggcc cctgagaaga cctacgcaga cacctggctg cccccagcgt 9661 cctgccatcc gttcatccag cacacatttc caggggttct tgccctgtgt ggggagatag 9721 gggtccctca ctgttctcac agagtgttca gctggtgggg agacaagagg aaatacagaa 9781 acccacagat gaacaagata attcaaaagt gccatgaagc caagacatgg gtgtggtgga 9841 gaatgaccga ggggagccac ctcagatagg aggagttgag gccgggcaca gtggctccca 9901 cagcagtgcg ggaggcctag gagggagggt cgcttgagcc caggagttca agaccagact 9961 gggcaataca gcaagaccct gtctctacaa aaaagacaaa aatgagccag gagtggtggc 10021 acacacctgt catcccagct actcaggaga ctgaggtggg aggatcactt gagcccggga 10081 ggttgaggct gcagtgaatc gtgattgtgc cactgcactc cagccagggt gacagagtga 10141 gaacctgcct caaaaacaaa taaaaagagg ccaggcacag tggctcacac cgtaatccca 10201 gcattttggg aagctgaggc aggtggatca tttgaggtca ggagtttgag accagcctgg 10261 ccaacatggt aaaaccccat ctctactaaa aatacaaaaa tcagctgggt ctggtggcac 10321 acacctgtaa tcccagcgac ttgggagact gaggcaggag aatcgcttga acctgggagg 10381 cagaggttgc agtgagctga gatcacgcca ctgcactcca gcctggggga cagagtgtga 10441 ctccatctca aaaaaaaaag ttatgtttat cctatactgt agtctgttaa gtgcacaata 10501 gcattatgtc tagaaaaaaa aaagtacata ccttaatttt aaaatcctgc taaaaatgtt 10561 gtgatcattt gaggactcag caagttggaa cctttctgtt gtgtagggcc ttgccttgat 10621 gttgatgggc tgctgactga tcagggcggt tgtcgttcaa ggttgagatg gctgcggcaa 10681 ttccttcctt ccttccttcc ttcctttcct ttcttttctt cctcccttcc ttcccttcct 10741 tccctccctc ccttccttcc cttcccttcc cttttcttct ccgtccttcc ttccttcctt 10801 ctttcctccc tcccttcctc ccttccttcc ttccttctct ttctctctct cttttcaaga 10861 cagggtcttg ttctgttgcc cagctggaat gcagtggtgc aatcatgact taccataacc 10921 tccaactcct gggcttaagt gatcctccca tgttggtctc ccaaagtgct ggcattacag 10981 gtgtgagcca cagtgcctgg ccagcagtaa tagtttgaaa agaatctctt ttttgagatg 11041 gagccacact cttgtcgccc aggctggagt gcagtggtgc aatcttggct tactgttacc 11101 tccacctcgt ggttcaagca attctcgtgt ctcagccacc caagtagctg agatcaccgg 11161 catgcgccac cacgcctggc taatttttgt atttttagta gaatcggggt ttcgccatct 11221 tggccaggct ggtctcaaac tcctgatctc aggtgatctg cctgcctcag cctcccaaac 11281 cactaggatt acaggcgtga gccaccgcac ctggcctatg aagcttttta tttaaagtga 11341 aaaatgttga ctcttccttt cacttgaaca cctcgaggcc attgtaaggt tatgaactga 11401 attggcctga tttcaaaatc atgtgtctca gggaatacgg aggctcaagg agatggggag 11461 agatgaggga atggctggtc agtggggcag tccgagcaca cacatttatc cattaagttc 11521 acccttttat atgggcaagg tcggtggcac cccccaaaat taaaacagta acatcagaga 11581 tcactgatca cggatcgcca tgacagatat agtaataatg agaaagtctg cagtactgtg 11641 agaattaccc acatgtgaca cagagacacg aagtggcaca tgctgtagga aaaatggctc 11701 caatagacct gctggacaaa gagttgccac aaacctccaa tttgtaaaaa acacagtatc 11761 tgcaaaatgc aataaaacga ggtatgtctg tatattatat gaatatgtat aagatatata 11821 aatattatag atttattgta catatgcaca aacacaaatt cattatacac atattttata 11881 catgaatata caaataaaca cacaattttt tttctttttt ttttttttag acagaatctc 11941 actctgtcac ccaggctgga gtgcagtggc aaaatctcag ctcactgcaa cctccacctc 12001 ttgggttcaa gtgtttctcg tgcctcagcc tcttgagtag ctgggattac aggcgtgtgc 12061 caccatggcc gactaatttt tgtattttta gtggagacgg ggtttcacca tgttggccag 12121 gctggtctca aaatcctgac ctcaagtgat ctgcctgcct tggcctccca aagtgctggg 12181 attataggca tgagccactg cgcccagcct acaatttttt tttttttaaa gattggggtc 12241 ttgggccagg cgcccaagtg gagaaacccc gtctctacta aaaatacaaa attagccggg 12301 catggtggcg catgcctgta atcccaggta cttgagaggc tgaggcaaga gattcgcttg 12361 aacccgggag acggaggtgg cagtgagcca agatcgcgcc attgcgctcc agcctgggca 12421 acaagagcaa aactccgtct cataaaaaaa aaaaaaaaag atgggggtct tgctatgtta 12481 cccagactgg actcgaactc ctgggcttaa gtgatcctcc tgcctcagcc tccccagtat 12541 ctggactaca ggctcgtgcc agtgcacctg gctaccattc tactttataa taatttttac 12601 taatggcctc tcaaagtcct gagacttcag ccatctgtgt tgccagccat taggagcagg 12661 caccagcaca ctgtggcctg caggtggatt ggatgtgagg gtccctcagg ggaagaggtg 12721 ggtctgtttt ccagattgag cacatggggt ggccattcct gggggcctgg acagatggca 12781 ggaacagatt ttggggagcc gtcacaagtg tgggtttaga cacagggttc aggtgccttt 12841 aggacatcca gggggccaag gcccaggccc gttaggagca gcagcagggg gaaccctggg 12901 cctccacacc ctggttgagg tgggacaggc tgctgaccac tccctcgtgt gtccccatag 12961 ctctcaacag cctgacgggc gagttcaaag ggaagtacta ccctctgaag agcatgacgg 13021 agaaggagca gcagcagctc atcgatgacc acttcctgtt cgacaagccc gtgtccccgc 13081 tgctgctggc ctcaggcatg gcccgcgact ggcccgacgc ccgtggcatc tggtgaggcc 13141 cctccccgcc ccctggcttc ctcttccccc agcctcctcc agtcctgcaa cggccctcct 13201 cactcctcca ccaaaaccaa ggccatatac ataattatga tcttctaaat gccacggaaa 13261 atgatcttgc cctccgcccc tgcccatcct gtggtctgtg tgtcagattt tgggatatct 13321 ggaccggaga agtggtagtt aaaaacttaa gacttggcgg ggcacggtgg ctcatgcctg 13381 taatccctgc actttgcgag gccaaggcgg ggggatcact tgaggtcagg agtttgagac 13441 cagcctggcc aacacggtgt ctactaaaaa tgacaaaaat ttagctgggc gtagtggcag 13501 gcgcctgtag tcccagctac ttgggaagat gatgcaggag aatcgcttga acccaggtgg 13561 cggaggttgc agtgagccga gatcgtgcca ctgcactcca gcctgggcga cagagccaga 13621 ctgtctcaaa aaaaaacaaa caaaaaagaa agaacttaga cttggccggg cacagtggct 13681 cacacctgta atcccagcac tttgggaggc tgcagcagga gggtcgcttg tgcccaggag 13741 ttctagacca gcctgggcaa catagggaga ccacgtcgct acaaaaatta aaaaaaaaaa 13801 aagccaggcg cggtggctca cgcctgtaat cccagcactt tgggaggcca aggtgggcgg 13861 atcacgaggt caggagattg acaccatcct ggctaacacg gtgaaacccc gtctctacta 13921 aaactacaaa aaaaaaaaaa aaattagccc ggcgtcgtgg caggcgcctg tagtcccagc 13981 tacttgggag gctgaggcag gagaatggcc tgaacccaag aggcggagct tgcagtgagc 14041 tgagatcgtg ccactgcact ccagcctggg cgacaggaga ctccgtctca aaaaaaaaaa 14101 aaaaaaaaaa aaaaaaaaaa agccaggcgt gatggcgtat acctgtggtc ccagctactc 14161 gagaggctga ggatcagctg ggcccagagg attgaggtta ctgtgaatca tgaccgaggt 14221 actgcactcc agctacctgt ctcaaaaata agaactcaga cttgaaccgt actccctagg 14281 ttcaaatccc agctctacca tttactagat ttactagctt tgtgaccttg ggcaacttat 14341 tttatttttc tctaccccag tttcctagct ataggatagg gatcacaata atttgtagtt 14401 tctggtgttc ttgtgaggat taaatgagtt aatttatgta aagtattaaa agcagtgcct 14461 gggccaggcg cggtggctca cgcctgtaat cccagcactt tgggaggcca aggcgggcgg 14521 atcacgaggt caggagatcg agaccatcct ggctaacatg gtgaaacccc gtctctacta 14581 aaaatacaaa aaattagctg ggcttggtgg caggcgcctg tagtcctact tactcgtgag 14641 gctgaggcag gagaatggcg tgaacccggg aggcggagct tgaagtgagc caagatcgca 14701 tcactgcact ccagcctggg cgacagacca agactctgtc tcaaaaaaaa aaaaaaaaaa 14761 aaaagcagtg cctggtatac actaagtgtt cagtacatct tggttattcg tcttatcttt 14821 attataaagt attattgcta gacttgtttt gactctttga atccctgatt cagatagtca 14881 aagatttaga gaacctaggt ttcaatcgat gaagggagcc tgggtgctaa gatatacaga 14941 tgggatgatt ctaagatttc aagattttaa atatttttag gttttaagat tccactcatt 15001 tatttattta tttattttga gatggactct cactctgagg cccaggctgg agtgcagtgg 15061 gttgatctcg actcactgaa acctccatct cccgggttca aacgatcctc tcaccctccg 15121 cctccttagt agctaggacg acaggcatgt gccactgtgc ccagctagtt ttcgtatttt 15181 tggtagagac agcgttctgc catgttgctc aggctggtct cgaactcttc accttaagtg 15241 atccgcccac ctcagcctcc caaagtgctg ggattacaag cgtgagccac catgcctgcc 15301 ctcaggtttt tttttttttt tttttgagac agggtcttgc tctgttgccc aggctggagt 15361 gcagtggtgg gatcatagct cgctgcagcc tggaccttcc aaggtcaagt gatcctcccg 15421 cctcagcctc cccagtggct tggactacag gcatgtgtcc caccatgcct gctaattttt 15481 taaattttgt agatatgtgg gtcttgccat gttgcccagg gtagtcttga actcctgggc 15541 tcaagcaatc ctccggcctt ggcctcccaa agtgctggga ttacaggcat gagccaccac 15601 acccggccat ttccggatct taatatttta tgttcttttt tttttttttt tttgagatgg 15661 agtctcgctc tgttgcccag gctggagtgc agtggcgcga tctcgactca ctgcaagctc 15721 cacctcccgg gttctcgcca ttctcttgcc tcagcctcct gagtagctgg gactacagat 15781 gcccgccacc atgcccagat ttttttttgt attttttagt agagacaggg tttcgacgtg 15841 ttagccagga tggtgtcgat ctcctgacct tgtgatccgc ccgcctcggc ctcccaaagt 15901 gctgggatta caggcgtgag ccaccgcacc cagccttaat attttatgtt ctaagatcct 15961 gcttctgaga tgctaggatt gggagctaac acactacgat gggaagattt tctggtcctg 16021 aaaccagatg taggatttcc aagtgttatc agttctgatc ccaagcttct gtttgtcaaa 16081 catcctgaga tcccaaggat ctataataat actgttcaaa gacttaagtc cctaaaagtc 16141 cttgatccca ggattcagcg ttttgcagat cctgtgacat tagagtctac aggtttaagc 16201 ttctgcgttt tgaggaggca gatgccaccc acctcccacc cctcaggccc tcttccccca 16261 tcggtgggca gatgttttgg gggagggctg ggaatggggt tcccacgggg ctgacacctt 16321 ggcctcttgc tgcggcacct tactctaggc acaatgacaa caagagcttc ctggtgtggg 16381 tgaacgagga ggatcacctc cgggtcatct ccatggagaa ggggggcaac atgaaggagg 16441 ttttccgccg cttctgcgta gggctgcaga aggtgggtgt ctgcccttag ctgctgactt 16501 ctgactccac cttgaacgcc ccacctgctt tccgaggccc cgccccttcc cctatactaa 16561 gccctgcccc acccattttc cagggccctg ccccccggac ctggctccac cccatgccaa 16621 accccgcccc ccaaaactag ccccacccgc ttttcagggc cccgcccctg gacccagctc 16681 caccctatgc ccaagccccg cccgtaagga tccgccttca ggccgggagc ggtggctcac 16741 gcctgtaatc ccagcacttt gggaggctga ggagggtcag gagttcaaga ccagcctggc 16801 caacatggtg aaaccccgtc tctatactaa aaaattaata aataaataaa ttatccaggc 16861 gtagtggcgc gcgcctgtag tcccagctac tcgggaggct gaggcaggag aatcgcttga 16921 acctgggagg cagaggttgc agtgagacga gatcacgcca ttgcactcca gcctgggtga 16981 cacagagaga ctctggaaaa aaaaaaaaaa aaaacccgcc ttcaaagcgt tcttagtccc 17041 cgcccctcaa aatcctgcct tggtccccat tgtctagcca gcaccctcgg aatctcctac 17101 ctccctgttc ccctcagaat cccacctcca ccacgttccc acgccctgtc cctccggacc 17161 ctgtccatgt tgcgggtgca tttgggggtg cctgccggcg ctgacccctg gtcctctctc 17221 tgaacctcag attgaggaga tctttaagaa agctggccac cccttcatgt ggaaccagca 17281 cctgggctac gtgctcacct gcccatccaa cctgggcact gggctgcgtg gaggcgtgca 17341 tgtgaagctg gcgcacctga gcaagcaccc caagttcgag gagatcctca cccgcctgcg 17401 tctgcagaag aggggtacag gtacggctcc cacatccttt gcaccacgac ggagggggag 17461 cgagggccct ttgcagggat gcaaggagag gtgcgacatc cctgcgagtt ctggggatcc 17521 ggcaagggct gaccctctgt gagcttgcat ttcttcctct gtaaaatggg tgtcaatatg 17581 cctatgtgat aggagtcaat gtgggatttt catgattata taatatgcat tgcacatgcc 17641 cttggacctc cctcggggcc tcagtttccc catttataaa gcgaggagtg gtcaggattc 17701 gaccctaggc cgcctggctc cagaacccac tctcttaccc actatactat gtttgataac 17761 tgagtggcgt ggtaccccat ctgaagtcag agactcgtga gctcacgaat gaacaggcat 17821 tacctgtgtg caggtaacct gttacacagt aggcactcac tacatgcggc tgttgcattt 17881 ggcacggggg ccacgtccca gcccctctgc accttcgctg cctcttcacg cccctgtccc 17941 ttgctcccac aggtggcgtg gacacagctg ccgtgggctc agtatttgac gtgtccaacg 18001 ctgatcggct gggctcgtcc gaagtagaac aggtgcagct ggtggtggat ggtgtgaagc 18061 tcatggtgga aatggagaag aagttggaga aaggccagtc catcgacgac atgatccccg 18121 cccagaagta ggcgcctgcc cacctgccac cgactgctgg aacccagcca gtgggagggc 18181 ctggcccacc agagtcctgc tccctcactc ctcgccccgc cccctgtccc agagtcccac 18241 ctgggggctc tctccaccct tctcagagtt ccagtttcaa ccagagttcc aaccaatggg 18301 ctccatcctc tggattctgg ccaatgaaat atctccctgg cagggtcctc ttcttttccc 18361 agagctccac cccaaccagg agctctagtt aatggagagc tcccagcaca ctcggagctt 18421 gtgctttgtc tccacgcaaa gcgataaata aaagcattgg tggccttagc tttgtgcgat 18481 agttattgag ggaggacgtg caattggcca ctgtgtggtc tcagagtggt ttgtcctgtc 18541 taggcatgta ctaaacatgt cttatcccgg gtctaaaatg aggcaaagtt aggtcacaga 18601 atctagtcca aaaattagaa ggctctatgg ggaatctgag acccagagag acactgagcc 18661 cagtgtcact cacccaaagc atgggccctt tccaactatg gctttgaatt agtcatgctc 18721 agatctcaaa cacgaggtcc acgctgggga ggaatgcagc caaacgaaat gtctgaaact 18781 tgaatttagc ccaacggtct ccagttttga gacctcccat gcagctcgtc acatctacct 18841 atattctgct tctcagtggc ctccttctgt cccgtctgac ttcatccctc tgtagctgct 18901 gccagtccct tactttctca agaacctgcc atggctcccc atttctccta gaaagctttt 18961 ctgttatttt gcaactcaag gccacactga aatgcatacc atttgctgga ggctcacctt 19021 tccagttctt tccccattac tcctctgatt ctttcacacc tgacaccctc caattcccac 19081 ctcaatgtct ttgaccaagc tgtttccctc tccaatctgt gagtctgagc atccccatga 19141 agtctttagg gataggcctt ttggagaact cagtcccagg aaggaacagg aaagaggtgt 19201 ggtagagcaa ttggtggagg gagaagagtt aatagaagtc aagcagtagc tgaacatgca 19261 ttgggtgttg ggcacgtcaa tcacctccac ccagtcaaac aggccaatgt ctacgttaac 19321 aaggacacag tcggtgggcc ccaaaagaca aacgttttag ggaaaaaaaa aagtgaggtg 19381 ggagtaaatg gaagaaccga caaagccctc aggaacctaa ggtgcttttt caaacctcaa 19441 gagtcacaga gattaagggc ccttgtagtt caatctgccc tctgttttac agaggggaaa 19501 ttgaggccta gggatgtccc caaaagttcc cagggagatt actacaagga aggttaggag 19561 agattctaaa cattaaggta tgcagaacct gtgagatgct gtgatgttct ttactgtact 19621 gtccccagtt gaagatccca gctccacacc cagaggctac atagaccaca cacgccagtg 19681 gggaccttct gagccagcca aagccacagt ccagacacct gttaccaggt cctgcccact 19741 ttgcctcaca ggactctctt aaatctatct gcgctctccc catctgtcca gccccgacct 19801 ctttcctgat cttctgacct gtcaacttcc ctcccttcca ccctgcacat agcacaaacc 19861 cgcccatctc taccctacct acaaccttgc catggctccc ccagtgccct tggaagaaag 19921 cccaggcccc tgtccataac cttcaaggcc ctactgacgc ccctagcccc atacctcaca 19981 gcaattctac acttaccaag tcacatgcca tttgttgagg acctgtcctc tctcttgctc 20041 cctggccctt gtatgtgcca tttgctgtgc ctaaaacgca ctcctatcca tgtctagctg 20101 gctccttctc ctccaggaag ccctccctgg ctgaggcagg catcacctct ggactcccct 20161 ataccagccc tgcccagtcg ctgcctgagg acacatctgc ctcctccatt ggactgtgag 20221 ctctatgagg gcagtgttgg ggctgtcttg attaccactg tgtccccagc acagaggatg 20281 ctctcaggaa ttgaccaagc ctcttccctg aagttccctg aacttccatg gttccccagt 20341 gccatgggga gaaagtccag cttattcatt ttggccccaa aggtgctgtg tgaataagct 20401 ccgcccttct gtactgcaca gacttcaacc actataatct gtccagctcc catg //