LOCUS AF545480 10073 bp DNA linear PRI 22-SEP-2002 DEFINITION Homo sapiens chemokine (C-C motif) receptor 2 isoform A (CCR2) gene, complete cds. ACCESSION AF545480 VERSION AF545480.1 GI:23267189 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 10073) AUTHORS Rieder,M.J., Armel,T.Z., Carrington,D.P., Ozuna,M., Kuldanek,S.A., Rajkumar,N., Toth,E.J., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (10-SEP-2002) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI HL66682 Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu). FEATURES Location/Qualifiers source 1..10073 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 225 /frequency="0.08" /replace="g" repeat_region 404..683 /rpt_family="Alu" /rpt_type=dispersed variation 589 /frequency="0.03" /replace="t" variation 696..698 /frequency="0.65" /replace="" variation 732 /frequency="0.18" /replace="a" variation 772 /frequency="0.01" /replace="g" variation 914 /frequency="0.10" /replace="g" variation 1181 /frequency="0.32" /replace="c" repeat_region 1218..1353 /rpt_family="L1" /rpt_type=dispersed repeat_region 1355..1511 /rpt_family="Alu" /rpt_type=dispersed variation 1435 /frequency="0.01" /replace="g" variation 1442 /frequency="0.13" /replace="a" variation 1502 /frequency="0.06" /replace="a" repeat_region 1512..1874 /rpt_family="L1" /rpt_type=dispersed variation 1518 /frequency="0.01" /replace="t" variation 1665 /frequency="0.02" /replace="a" variation 2075 /frequency="0.07" /replace="g" variation 2163 /frequency="0.01" /replace="g" variation 2263 /frequency="0.88" /replace="" variation 2348 /frequency="0.13" /replace="g" variation 2378 /frequency="0.01" /replace="c" gene 2403..9181 /gene="CCR2" mRNA join(2403..2431,5730..6721,7930..9181) /gene="CCR2" /product="chemokine (C-C motif) receptor 2 isoform A" variation 2549 /gene="CCR2" /frequency="0.13" /replace="a" variation 2693 /gene="CCR2" /frequency="0.08" /replace="t" repeat_region 2976..3051 /rpt_family="MIR" /rpt_type=dispersed variation 3080 /gene="CCR2" /frequency="0.01" /replace="t" repeat_region 3311..3710 /rpt_family="L2" /rpt_type=dispersed variation 3379 /gene="CCR2" /frequency="0.14" /replace="a" variation 3469 /gene="CCR2" /frequency="0.07" /replace="t" variation 3701 /gene="CCR2" /frequency="0.34" /replace="g" variation 3802 /gene="CCR2" /frequency="0.15" /replace="a" repeat_region 4079..4185 /rpt_family="MIR" /rpt_type=dispersed variation 4203 /gene="CCR2" /frequency="0.41" /replace="a" repeat_region 4322..4396 /rpt_family="L2" /rpt_type=dispersed repeat_region 4393..4836 /rpt_family="L2" /rpt_type=dispersed variation 4755 /gene="CCR2" /frequency="0.04" /replace="t" repeat_region 4845..4905 /rpt_family="MaLR" /rpt_type=dispersed repeat_region 4920..5190 /rpt_family="Alu" /rpt_type=dispersed variation 4922 /gene="CCR2" /frequency="0.21" /replace="t" variation 4944 /gene="CCR2" /frequency="0.01" /replace="t" variation 4970 /gene="CCR2" /frequency="0.02" /replace="a" variation 5022 /gene="CCR2" /frequency="0.01" /replace="c" variation 5054 /gene="CCR2" /frequency="0.21" /replace="t" variation 5127 /gene="CCR2" /frequency="0.08" /replace="g" variation 5222 /gene="CCR2" /frequency="0.08" /replace="c" variation 5252 /gene="CCR2" /frequency="0.04" /replace="t" repeat_region 5310..5434 /rpt_family="MaLR" /rpt_type=dispersed variation 5453 /gene="CCR2" /frequency="0.01" /replace="g" variation 5673 /gene="CCR2" /frequency="0.04" /replace="g" CDS join(5781..6721,7930..8113) /gene="CCR2" /note="encoded by transcript variant A; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor" /codon_start=1 /product="chemokine (C-C motif) receptor 2 isoform A" /protein_id="AAN16400.1" /db_xref="GI:23267190" /translation="MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQL LPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSA ANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVT SVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIM VICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSN CESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGG PGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA" variation 5936 /gene="CCR2" /frequency="0.02" /replace="t" variation 5970 /gene="CCR2" /frequency="0.16" /replace="a" variation 8005 /gene="CCR2" /frequency="0.04" /replace="g" variation 8052 /gene="CCR2" /frequency="0.01" /replace="a" variation 8503 /gene="CCR2" /frequency="0.01" /replace="a" repeat_region 8673..8789 /rpt_family="L1" /rpt_type=dispersed repeat_region 9338..9392 /rpt_family="MaLR" /rpt_type=dispersed repeat_region 9434..9551 /rpt_family="MaLR" /rpt_type=dispersed repeat_region 9942..10073 /rpt_family="Alu" /rpt_type=dispersed variation 10003 /frequency="0.08" /replace="a" ORIGIN 1 gtttatgaaa ttacagggct ggagacaaag atcacaatgt gaagacaaaa ttggagagcg 61 gtcctaatca gccagagcaa aatttctggc tcttgctctt ccccatcctg ggttgaatca 121 taggaacagg tggcaagatg ccagggtcag gagattccag aagtggcagc aagctcagtg 181 ttaccaggtc agggatgacc tgtcttatta ttgaaatctc agagatatgc tccaattccg 241 gcccagagac acattgagag acaactgggg aacttgctat gttcctgaac aggcaatgag 301 ctgtcttcca agaaaaaacc tgagaccctt caagtctcag gtcttactta gcacatatac 361 caggtcttac acaggacaca tggttacaac tgactgaaat ctgggctggg tgtaggagct 421 cacacctgta atcccagccc ttcaggaggc tgaggcaggc agattgcctg agcccaggag 481 ttcgagacca gcccgggcaa catgacaaaa ccccatctct acaaaaaata gtcaggcatg 541 gtggcatgca cctgtagtct cagctacttg ggaggctgag atgagaggat tgcttgaggt 601 tgagactgca gtgaagcatg atcatgccac cgcactccag cctaggcaac agagcaagat 661 cttgtcgcaa aagaaagcaa aaacacaaca taacacaaca acaacaacaa caacaacaac 721 agcaaaaaag ccaacttctt gaaatctgga aaggacacct ggactgccct gagcatttga 781 ttgttgttgg ctctagcagt ggatgcatcc ttcaacctct ggcactctgc agggctcaga 841 ctgttctgtt ctgtttgtta cctgtggagt gcctgccaga ccctgctcta gctgctttag 901 gtccatttac cctcatagac ccccagtctt gttattcata tttcatattt gggaaatgga 961 aacttagaaa cttgccaagt ccacagcatg agatcctgcc tccggtgtct gctggattcc 1021 agaaagtgcc aggggccaac ttagatgaca ccatgttctc tgcacaatct taggaatgct 1081 cctagtctga tgtccccatt gcaaaattta cattatcttt taacaaaacg tctttccaag 1141 gaggggcatt taaaataact gaggttcttc ttgctaagga agttcctgac acaagagata 1201 atttagcatt tccttttcat taaaaagttt gaaatcctgt aatttgtgat aatgtggatg 1261 aacctagagg atgttaagtg aaataagcca cacacagata gacaaatacc acgtgatctc 1321 actcttatgt ggaatttttt tttaaataag ttgcttagcc gggcatgatg gcacacacct 1381 gtaatcctag ctactcagga ggctgaggtg ggaggatggc ttgaactcag aaggtggagg 1441 ttgcagtgag ctgagactgt gccagtgcac tccggtctgg gtgacagaat gaaacccaat 1501 ttaaaaaaaa aaaaaaagtt gctatcttag aaaaagacag tagagcagtg gttaccagag 1561 actggggagg aaagagagga ggtgagaatg ggcagcagtt gatcaacggg tacaaagtta 1621 ccatgagata ggagaaacaa gtgctggtgc tctgctccaa gtagggtgac ggtagttaat 1681 aatgaattct gtatatataa atagctagaa gagagggttt tcaatatcat tattatttca 1741 aaagaaatga taaatgtttc agaggatgga tatgtaatta ccctgatttg atcattgcac 1801 aatgtataca tgtagcaaaa catcacattg tgtcccataa atatatacaa ttattatgtg 1861 aattaaataa aaaaaaattt taaagtctta tctaaatgaa atttctaacc agattctgaa 1921 tccatgatac cactgaaacc agcacacatg atcgcagtaa aacctcatta tacttcctcc 1981 actatcacca atacccttta ttctctggaa catgaaacat tctgttgtgc tcatatcatg 2041 caaattatca ctagtaggag agcagagagt ggaaatgttc caggtataaa gacccacaag 2101 ataaagaagc tcagagtcgt tagaaacagg agcagatgta cagggtttgc ctgactcaca 2161 ctcaaggttg cataagcaag atttcaaaat taatcctatt ctggagacct caacccaatg 2221 tacaatgttc ctgactggaa aagaagaact atatttttct gatttttttt tttcaaatct 2281 ttaccattag ttgccctgta tctccgcctt cactttctgc aggaaacttt atttcctact 2341 tctgcatacc aagtttctac ctctagatct gtttggttca gttgctgaga agcctgacat 2401 accaggactg cctgagacaa gccacaagct ggtgagttgt aggcattttt tccattactt 2461 tctgattcat aggctcaacg cacctcaaag ctggaaatgc cgggtctggg tacaccctgg 2521 ggaactgcaa agcctgcaca cttgggggga atgatcaaga tgagaggcag gggtggggat 2581 ggcatgtgca ccaggagatg ttagagaaac cctgaggaag agcagcgtgc agcaggtgat 2641 gggggagagt gggcagcaag cgaggccagg acagccactc tgctcagtca ccagtccaca 2701 cacccagggg ctcactctgc ccctctgagc acccaaggac gttaaagagc tggaactgtt 2761 agtctaaata taggaccatc caagctctga accaaaatgt gtcccttgcc tcaactcagg 2821 agatccacag aggcagaagt aaggaattta ttttctgaaa gatagatttc tatcagttct 2881 gggtgacatg ttctgacact tgaaatgaca cctaggacag cacatttcag gcatcttgct 2941 cattgttcac tgtagtagaa gctacatgct agccagttgt aaaaatgaaa ttaagtaatg 3001 tgtgcacagc atttaacata gcatctgagc ttcaggagca ctcaattaat gaccacagtt 3061 gtgattcttt aggcagatgc atttttttcc aactttgatc agaggtctta tttagcttct 3121 ccagatttca agaatctggc tcagtgatat gaaatacaag acttgtgaaa agtgtcaatt 3181 gcaagagaaa tggaaggata aagtatacag gtgggtggaa aagaaattca cagtcactgc 3241 cagaaaaaaa attcttgaga atcaagtcct gatgatgtta gggcttatag ttcttattat 3301 aaagagtttt atgtactcat tcagtgaaca tttattggtg cctcctttag ccaggtacta 3361 tcataagagc tgaaaataga agcataatcc agtccttgat cttgaggaac atgctgtgtg 3421 tagcagataa cataataagt gcttatctag atgcatgcag tgttatgtga taagagtaat 3481 atgacagagg atacagatta ggcttcacag agaaggggga tttgagcagg aggtattgaa 3541 gggtgaatag aagctcacca atcattttgg gcagaggggc aaggacctgc aaaaccactg 3601 aagcatgaag gaaatggtga gtttagggaa aatgaagaga agatggctgt gactgaagca 3661 caggatttgg gattggagaa gggactggag gtgaggctga aaagaggcaa actcagaaaa 3721 gatgttgtgc tgggcagtct ggacattatc tttgaagccc accacatata agtcataggg 3781 ctactggagg ttttaagcta agagtgacta ttcaatttca acttaagaga agataggttg 3841 agagggaaca tggcttgaga tgagccatga gcaaaggaaa gactacaaca aagccaggag 3901 tgaggagtgt gtgaagcaag aaagtgacag ttgaaagcag tgcagagggg atgaatctga 3961 gaggcatcta tgaggtggaa ctcaaatgac atgataataa tacagggcat ttctctgtgt 4021 cagatgctgt cctaagtcct tactccattg atcttcacag caactcagca tagttaatat 4081 tttatgcata aagaaatcgg cacttgaagg agtaattggc cccagattac actgcctata 4141 aggattcaaa tccaggtttg tttggctcca aaaactggct cctaattttc agaaggagaa 4201 gcgacccagg gcaatgccca attttgcttc ttaggcaatg gaggaatcca caatcggaag 4261 gagttttcag cagtgcccca tttggggtgg gttgaatttg aggtccctgc atgataccca 4321 ctttgctcac ttcagtgcct aaaactgagt atggttcata gtaggtgttc aataagtgtt 4381 gatgcagtga atacatgcat ggggagatat gcatcaggca atgggaaatt caactctaag 4441 gcttagggga aagctggagc ttgaagacag agctttagaa aacagtagca tagaagggag 4501 taggaaccat gagtttagac aatacaattc aggaagaact ttgtagcaag gataaagagg 4561 caaaaaatta aagaggtgag agctaagtgt ggtgcctggg gaatcttaag gtgtgggcac 4621 ggggaggaga tgccagcaaa gaacatgaat aaaaagcggt agcacagccc ctcccatctg 4681 gaagccaaaa agaattgtaa atggaggaag ttagcagaag gatcaaatac ttgaagaggg 4741 tggaattgga ataaaaccag ggcatttgaa aaattgggtt gtcactgcaa tcttaacaag 4801 agaagttttg gcaggatgat ggaggcagaa agctgagaga atcatcagtt agaacgtttt 4861 tgacttcaga gaacagaaaa tgcagttcat aatggcttta aaacaggggc ttgtttttct 4921 cccagcaatt tgagaggcca aggcgggtgc atcaggaggt caagagaccg agaccatcct 4981 ggccaacatg gtgaatcccc atctctacta aaaatacaaa aattagcggg gcatggtggt 5041 gcacgcctat agtcccatct actcaggagg ctgaggcagg agaatcactt gaacccagga 5101 ggtggaggtt gcagtgagct gagatcatgg ccactgcact atagcctgga gacacagcga 5161 gactccgtct ccaaaaaaaa aaaaaaagaa ggcagaaggt gaatagttca agggtgggtt 5221 taggactcag tgataatagg attctgcctg gcttctcatg gttctctagg tcttccattc 5281 atggcaccat gccctcacta ggcatgctgc cagagcagga ggggcaggtg gagggttctc 5341 ttgtgtctgt cttatcaggg aagaagagct ttctcagaag cccccagcag actccctttt 5401 catattatgg tccagcaatg agtcacagac ctatgcacca cctgcaaagg agccagagaa 5461 aacaaacgcc cagcgctttt agcctgaaaa tgagaatctg gtttgctggg gaagataaag 5521 ggtgtcggaa aatggctgtt gggtaaatca ttgatgtctg ccactaggaa tgaaaggcaa 5581 atcaggaact ggcacacatg ctttcaggga gatggctgca agggagaggg caaagactgg 5641 gaagttgctt atgtggtgcc agactatttg gaagatcatg gattgcggtg tttgtgttgt 5701 gtggtcatca ttttgttctt tgtttacaga acagagaaag tggattgaac aaggacgcat 5761 ttccccagta catccacaac atgctgtcca catctcgttc tcggtttatc agaaatacca 5821 acgagagcgg tgaagaagtc accacctttt ttgattatga ttacggtgct ccctgtcata 5881 aatttgacgt gaagcaaatt ggggcccaac tcctgcctcc gctctactcg ctggtgttca 5941 tctttggttt tgtgggcaac atgctggtcg tcctcatctt aataaactgc aaaaagctga 6001 agtgcttgac tgacatttac ctgctcaacc tggccatctc tgatctgctt tttcttatta 6061 ctctcccatt gtgggctcac tctgctgcaa atgagtgggt ctttgggaat gcaatgtgca 6121 aattattcac agggctgtat cacatcggtt attttggcgg aatcttcttc atcatcctcc 6181 tgacaatcga tagatacctg gctattgtcc atgctgtgtt tgctttaaaa gccaggacgg 6241 tcacctttgg ggtggtgaca agtgtgatca cctggttggt ggctgtgttt gcttctgtcc 6301 caggaatcat ctttactaaa tgccagaaag aagattctgt ttatgtctgt ggcccttatt 6361 ttccacgagg atggaataat ttccacacaa taatgaggaa cattttgggg ctggtcctgc 6421 cgctgctcat catggtcatc tgctactcgg gaatcctgaa aaccctgctt cggtgtcgaa 6481 acgagaagaa gaggcatagg gcagtgagag tcatcttcac catcatgatt gtttactttc 6541 tcttctggac tccctataat attgtcattc tcctgaacac cttccaggaa ttcttcggcc 6601 tgagtaactg tgaaagcacc agtcaactgg accaagccac gcaggtgaca gagactcttg 6661 ggatgactca ctgctgcatc aatcccatca tctatgcctt cgttggggag aagttcagaa 6721 ggtatctctc ggtgttcttc cgaaagcaca tcaccaagcg cttctgcaaa caatgtccag 6781 ttttctacag ggagacagtg gatggagtga cttcaacaaa cacgccttcc actggggagc 6841 aggaagtctc ggctggttta taaaacgagg agcagtttga ttgttgttta taaagggaga 6901 taacaatctg tatataacaa caaacttcaa gggtttgttg aacaatagaa acctgtaaag 6961 caggtgccca ggaacctcag ggctgtgtgt actaatacag actatgtcac ccaatgcata 7021 tccaacatgt gctcagggaa taatccagaa aaactgtggg tagagacttt gactctccag 7081 aaagctcatc tcagctcctg aaaaatgcct cattaccttg tgctaatcct ctttttctag 7141 tcttcataat ttcttcactc aatctctgat tctgtcaatg tcttgaaatc aagggccagc 7201 tggaggtgaa gaagagaatg tgacaggcac agatgaatgg gagtgaggga tagtggggtc 7261 agggctgaga ggagaaggag ggagacatga gcatggctga gcctggacaa agacaaaggt 7321 gagcaaaggg ctcacgcatt cagccaggag atgatactgg tccttagccc catctgccac 7381 gtgtatttaa ccttgaaggg ttcaccaggt cagggagagt ttgggaactg caataacctg 7441 ggagttttgg tggagtccga tgattctctt ttgcataagt gcatgacata tttttgcttt 7501 attacagttt atctatggca cccatgcacc ttacatttga aatctatgaa atatcatgct 7561 ccattgttca gatgcttctt aggccacatc cccctgtcta aaaattcaga aaatttttgt 7621 ttataaaaga tgcattatct atgatatgct aatatatgta tatgcaatat atataggctc 7681 ttgcttgatc tctccaggag gtagtgatta tgagaagggg gtggagaatg atgagttcct 7741 tcaccaggag caaaggacgg ggatcgtgtg gaaccactgc agaactattt ccgaaatcaa 7801 ctaagtggag agagccagga aggctgcatc agaacccagt aaagcttctt gtctggatct 7861 gagctggttt gttttgtgct tgcttttccc tgccttgcca ctcccctcac tcttctcttt 7921 tccccacagc ctttttcaca tagctcttgg ctgtaggatt gccccactcc aaaaaccagt 7981 gtgtggaggt ccaggagtga gaccaggaaa gaatgtgaaa gtgactacac aaggactcct 8041 cgatggtcgt ggaaaaggaa agtcaattgg cagagcccct gaagccagtc ttcaggacaa 8101 agaaggagcc tagagacaga aatgacagat ctctgctttg gaaatcacac gtctggcttc 8161 acagatgtgt gattcacagt gtgaatcttg gtgtctacgt taccaggcag gaaggctgag 8221 aggagagaga ctccagctgg gttggaaaac agtattttcc aaactacctt ccagttcctc 8281 atttttgaat acaggcatag agttcagact ttttttaaat agtaaaaata aaattaaagc 8341 tgaaaactgc aacttgtaaa tgtggtaaag agttagtttg agttactatc atgtcaaacg 8401 tgaaaatgct gtattagtca cagagataat tctagctttg agcttaagaa ttttgagcag 8461 gtggtatgtt tgggagactg ctgagtcaac ccaatagttg ttgattggca ggagttggaa 8521 gtgtgtgatc tgtgggcaca ttagcctatg tgcatgcagc atctaagtaa tgatgtcgtt 8581 tgaatcacag tatacgctcc atcgctgtca tctcagctgg atctccattc tctcaggctt 8641 gctgccaaaa gccttttgtg ttttgttttg tatcattatg aagtcatgcg tttaatcaca 8701 ttcgagtgtt tcagtgcttc gcagatgtcc ttgatgctca tattgttccc tattttgcca 8761 gtgggaactc ctaaatcaag ttggcttcta atcaaagctt ttaaacccta ttggtaaaga 8821 atggaaggtg gagaagctcc ctgaagtaag caaagacttt cctcttagtc gagccaagtt 8881 aagaatgttc ttatgttgcc cagtgtgttt ctgatctgat gcaagcaaga aacactgggc 8941 ttctagaacc aggcaacttg ggaactagac tcccaagctg gactatggct ctactttcag 9001 gccacatggc taaagaaggt ttcagaaaga agtggggaca gagcagaact ttcaccttca 9061 tatatttgta tgatcctaat gaatgcataa aatgttaagt tgatggtgat gaaatgtaaa 9121 tactgttttt aacaactatg atttggaaaa taaatcaatg ctataactat gttgataaaa 9181 gatttaaaaa caactggctg tttttttaca ctgtggtgtg gaagattgtg ttgtgttcac 9241 aacttttcac ttcttcccct gtgtgattac acacacctgc ccttgtggtg tgacttgcag 9301 tgcgccctac aggccacaca accccatgcc ctccaccact ggctctgctg ctggaatgtg 9361 agcagaagtg acatctgcct catccaagca gagcctcttg ctcagccaca ggaaggccca 9421 ttccagatca cacccgtcag cccgtgcgcc ctggtgaatg agaagacaca gggagctgca 9481 gccacatata acatgagcaa gaagtctgtg tttgctgtga taagccactg agttttaggg 9541 gttgtttgtt aagaagcaca aaaaccgatt aagacatgtg gtatatagtg acttcatata 9601 tagaatctgg aaaactatcc atttattttc aatcatggaa ttcaatatga caagcatccc 9661 ggagggtcta cctatgccag actgggttgg aaacagaaag acagatgtta atgccagtgt 9721 cctttacacc tccaagtcca gggccagctg tggagtggga ggggtagaga aggtcctgtg 9781 cacagtcaca gtgcgctgtg cagagcagga acagaggcat ctgtgaaaag tgctgagagc 9841 ctggaggaca gagtgactaa tgcaatgaca gtcttgcatc ataggaataa cagccacagc 9901 aggattttat tgctgccaaa gaaactgcca tttaaaaatt gccagccatc cgggaggctg 9961 aggcaggaga atggcatgaa tccaggaggc ggagcttgca gtgagccgag atcgggccac 10021 tgcactccag cctgggcaac agagccagac tccatctcaa aaaaaaaaaa aaa //