LOCUS AY953319 17649 bp DNA linear PRI 12-MAR-2005 DEFINITION Homo sapiens aquaporin 1 (channel-forming integral protein, 28kDa) (AQP1) gene, complete cds. ACCESSION AY953319 VERSION AY953319.1 GI:60549905 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 17649) AUTHORS Rieder,M.J., Johanson,E.J., da Ponte,S.H., Hastings,N.C., Ahearn,M.O., Bertucci,C.B., Wong,M.W., Yi,Q. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (03-MAR-2005) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: SeattleSNPs. NHLBI HL66682 Program for Genomic Applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu). FEATURES Location/Qualifiers source 1..17649 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 118 /frequency="0.04" /replace="a" variation 444 /frequency="0.17" /replace="t" repeat_region 445..497 /rpt_family="MIR" /rpt_type=dispersed variation 695 /frequency="0.01" /replace="t" variation 1041 /frequency="0.03" /replace="" variation 1059 /frequency="0.04" /replace="a" variation 1174 /frequency="0.01" /replace="c" variation 1237 /frequency="0.24" /replace="g" variation 1239 /frequency="0.34" /replace="t" variation 1615 /frequency="0.01" /replace="c" gene 1963..15631 /gene="AQP1" mRNA join(1963..2403,12176..12340,12674..12754,13560..15631) /gene="AQP1" /product="aquaporin 1 (channel-forming integral protein, 28kDa)" CDS join(2020..2403,12176..12340,12674..12754,13560..13739) /gene="AQP1" /codon_start=1 /product="aquaporin 1 (channel-forming integral protein, 28kDa)" /protein_id="AAX24129.1" /db_xref="GI:60549906" /translation="MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQT AVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQC VGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRR RRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFI GGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK" variation 2153 /gene="AQP1" /frequency="0.02" /replace="t" repeat_region 2436..2611 /rpt_family="MIR" /rpt_type=dispersed misc_feature 2496..3148 /gene="AQP1" /note="Region not scanned for variation" variation 3280 /gene="AQP1" /frequency="0.20" /replace="g" variation 3544 /gene="AQP1" /frequency="0.48" /replace="c" variation 3545 /gene="AQP1" /frequency="0.11" /replace="t" variation 3587 /gene="AQP1" /frequency="0.02" /replace="a" variation 3863 /gene="AQP1" /frequency="0.01" /replace="c" variation 3909 /gene="AQP1" /frequency="0.03" /replace="a" variation 3940 /gene="AQP1" /frequency="0.03" /replace="t" variation 3961 /gene="AQP1" /frequency="0.43" /replace="" variation 4180 /gene="AQP1" /frequency="0.03" /replace="t" variation 4309 /gene="AQP1" /frequency="0.03" /replace="t" variation 4612 /gene="AQP1" /frequency="0.06" /replace="c" variation 4873 /gene="AQP1" /frequency="0.02" /replace="c" variation 5082 /gene="AQP1" /frequency="0.01" /replace="" variation 5094 /gene="AQP1" /frequency="0.04" /replace="a" repeat_region 5108..5199 /rpt_family="MIR" /rpt_type=dispersed variation 5294 /gene="AQP1" /frequency="0.05" /replace="c" variation 5366 /gene="AQP1" /frequency="0.01" /replace="t" variation 5460 /gene="AQP1" /frequency="0.05" /replace="a" variation 5475 /gene="AQP1" /frequency="0.19" /replace="" variation 5485 /gene="AQP1" /frequency="0.01" /replace="c" variation 5612 /gene="AQP1" /frequency="0.27" /replace="g" variation 5618 /gene="AQP1" /frequency="0.26" /replace="a" variation 5623 /gene="AQP1" /frequency="0.37" /replace="a" variation 5633 /gene="AQP1" /frequency="0.01" /replace="c" variation 5812 /gene="AQP1" /frequency="0.35" /replace="a" variation 5862 /gene="AQP1" /frequency="0.31" /replace="g" repeat_region 5883..5930 /rpt_family="MIR" /rpt_type=dispersed variation 6034 /gene="AQP1" /frequency="0.01" /replace="a" variation 6034 /gene="AQP1" /frequency="0.14" /replace="t" variation 6166 /gene="AQP1" /frequency="0.01" /replace="g" variation 6343 /gene="AQP1" /frequency="0.01" /replace="t" variation 6502 /gene="AQP1" /frequency="0.01" /replace="t" variation 6561 /gene="AQP1" /frequency="0.01" /replace="a" variation 6640 /gene="AQP1" /frequency="0.01" /replace="t" variation 6671 /gene="AQP1" /frequency="0.03" /replace="t" variation 6702 /gene="AQP1" /frequency="0.01" /replace="a" variation 6718 /gene="AQP1" /frequency="0.38" /replace="g" repeat_region 6857..6975 /rpt_family="CR1" /rpt_type=dispersed variation 6924 /gene="AQP1" /frequency="0.01" /replace="t" variation 6946 /gene="AQP1" /frequency="0.17" /replace="t" variation 6984 /gene="AQP1" /frequency="0.36" /replace="g" misc_feature 7087..7803 /gene="AQP1" /note="Region not scanned for variation" repeat_region 7188..7266 /rpt_family="MIR" /rpt_type=dispersed repeat_region 7824..8075 /rpt_family="L1" /rpt_type=dispersed variation 7994 /gene="AQP1" /frequency="0.01" /replace="a" repeat_region 8106..8401 /rpt_family="Alu" /rpt_type=dispersed variation 8145 /gene="AQP1" /frequency="0.01" /replace="t" variation 8178 /gene="AQP1" /frequency="0.01" /replace="t" variation 8197 /gene="AQP1" /frequency="0.10" /replace="t" variation 8270 /gene="AQP1" /frequency="0.02" /replace="a" variation 8359 /gene="AQP1" /frequency="0.18" /replace="t" variation 8903 /gene="AQP1" /frequency="0.35" /replace="t" variation 9206 /gene="AQP1" /frequency="0.03" /replace="g" variation 9281 /gene="AQP1" /frequency="0.33" /replace="t" repeat_region 9311..9492 /rpt_family="L2" /rpt_type=dispersed variation 9497 /gene="AQP1" /frequency="0.48" /replace="t" variation 9622 /gene="AQP1" /frequency="0.01" /replace="" variation 9647..9653 /gene="AQP1" /frequency="0.01" /replace="" variation 9665 /gene="AQP1" /frequency="0.44" /replace="c" variation 9979 /gene="AQP1" /frequency="0.31" /replace="a" variation 10059 /gene="AQP1" /frequency="0.01" /replace="t" variation 10059 /gene="AQP1" /frequency="0.32" /replace="g" variation 10389 /gene="AQP1" /frequency="0.01" /replace="a" repeat_region 10687..10832 /rpt_family="MIR" /rpt_type=dispersed variation 11490 /gene="AQP1" /frequency="0.13" /replace="a" variation 11818 /gene="AQP1" /frequency="0.01" /replace="t" variation 12247 /gene="AQP1" /frequency="0.01" /replace="t" variation 12285 /gene="AQP1" /frequency="0.02" /replace="a" variation 12384 /gene="AQP1" /frequency="0.01" /replace="t" variation 12489 /gene="AQP1" /frequency="0.03" /replace="c" variation 12621 /gene="AQP1" /frequency="0.01" /replace="g" variation 12632 /gene="AQP1" /frequency="0.01" /replace="g" variation 12773 /gene="AQP1" /frequency="0.01" /replace="" variation 12913 /gene="AQP1" /frequency="0.18" /replace="" repeat_region 13016..13212 /rpt_family="MIR" /rpt_type=dispersed variation 13030 /gene="AQP1" /frequency="0.02" /replace="a" variation 13252 /gene="AQP1" /frequency="0.01" /replace="g" variation 13805..13809 /gene="AQP1" /frequency="0.76" /replace="" variation 14106 /gene="AQP1" /frequency="0.01" /replace="a" variation 14145 /gene="AQP1" /frequency="0.01" /replace="t" variation 14256 /gene="AQP1" /frequency="0.01" /replace="c" repeat_region 14263..14379 /rpt_family="MIR" /rpt_type=dispersed variation 14269 /gene="AQP1" /frequency="0.39" /replace="c" variation 14322 /gene="AQP1" /frequency="0.35" /replace="g" variation 14389 /gene="AQP1" /frequency="0.24" /replace="g" variation 14645 /gene="AQP1" /frequency="0.20" /replace="t" variation 14805 /gene="AQP1" /frequency="0.03" /replace="g" variation 15078 /gene="AQP1" /frequency="0.01" /replace="a" repeat_region 15301..15331 /rpt_family="MIR" /rpt_type=dispersed variation 16173 /frequency="0.03" /replace="g" variation 16352 /frequency="0.01" /replace="a" variation 16555..16558 /frequency="0.01" /replace="" variation 16693 /frequency="0.15" /replace="t" repeat_region 16909..17134 /rpt_family="MIR" /rpt_type=dispersed variation 17287 /frequency="0.35" /replace="t" variation 17316..17343 /frequency="0.94" /replace="" variation 17453 /frequency="0.37" /replace="g" ORIGIN 1 ctcctcatgt gggtcagtgt ccctgccagg gcatggggcc aggggccagg ggccaggggc 61 atgagggagc ctcccagaga ctggaatgct gagccagggc tcctcagagg aaaggatgta 121 gaggagggcc caggaagtag cccagtgggg ccagtttcct ctcctggaca gctaagaaag 181 tacttatgac cttcggccac ctgggctgtc tgagcaggca gggcctgctg gccaccaccg 241 tcctgtacag gcacttaggg gaatgaatct tccccacctg cagccccagc aaacacacac 301 caggctggtc cctggcaatt caccccaaga gccaggccac agctgggcag aggggtggcc 361 agtaacagct ggtgtcattc tctgcaggat agcccctgga caagaggcat aagacccact 421 catccttgcc ctgccccagg cacacttaga aaagtcctct caccgggcct cagtttccca 481 cctataaatg ggaagatgcc aacacgcccg agtgggactg tggtggggca ggcaggaggt 541 gggaggagag cccagatcat cccaggcctt ccctagggga cgcaggggga ccctcccttc 601 tgggcctggt tcttccagca cgttccatgc agcaggcaag agggccaggc ccaggggttc 661 ctgacagctt gctggccctg gagtccagat tcttgtttgt tggctggcgc taggcctctg 721 gattggagat gcccggggca caggcggccc acggggatct gcagcagggc ctcggcccct 781 ccctctgcag gggctcgtct ggtccctccc gctctctgcc tctcctcatt tatctctccc 841 tttctgcttc ttggctctgg gtccagtcct atctcccctg tttcagtttg tcttttccta 901 gccctttgcg ctctctctgt ctctctcagc cctgcttgtc tcactgtctc tggctggggg 961 atctgtctct ttcacttcca cttttgctct atttccctgc tactgtcttt cctttctcct 1021 tgtctgtctc ttctcctccc ctcagccagc atctgtctgt ctctgccttt ctctcctgct 1081 ccctccctcc ctcctctcca gcaccttcca atgccaggtg gggctgccat tccttccacc 1141 ttcccagtga cccgccagtg tgactgcctt gagaggaaag tcctaaactg tccctatctt 1201 caccagcctg ccctcaaatc attggttcaa atcgctctcg agaagtttgg gagctcccag 1261 ggcgggggct ttctaacagc tctgcctagc tcgggcctgc cctcaaccgc agcatgcagg 1321 gcagccacag acaacctctc tgcaacttct gatgcctccg tgcccccatc cacagagccc 1381 tggctctggg ggactgggga ctctgggaca tccctaacat ggcatgcagt ggcggtgcgg 1441 gaggacttga ctgcccctct ggagccctgg gcccggggac tccaggccag tgcctctctg 1501 ggtcgggatg gggatgtcag gccagcagga tcatggtacc tgcctccagg gagggcaacg 1561 tccacccact gagtccagcc cgcccacccc acccactccg gagcacctgg ctctgccctc 1621 aggaactccc tgagctttgc acacagggcc gagacacctg gatttctctg gttccctgag 1681 tggggccagc ttggaagaat ttcccaaagc ctattagagc aacggctgcc tcctgcctgc 1741 ctccttgggc tgggcagggc tgagggcgga gggagagaga gagagaggga gggggagagg 1801 aggaaggaaa aagttggcag gccgacagca cagccgtgtc tgcatccatc cagaggaggt 1861 ctgtgtggtg tggggcgggc caggagcgaa gagaggcctt cctccctttg tgctcccccc 1921 gccccccggc cctataaata ggcccagccc aggctgtggc tcagctctca gagggaattg 1981 agcacccggc agcggtctca ggccaagccc cctgccagca tggccagcga gttcaagaag 2041 aagctcttct ggagggcagt ggtggccgag ttcctggcca cgaccctctt tgtcttcatc 2101 agcatcggtt ctgccctggg cttcaaatac ccggtgggga acaaccagac ggcggtccag 2161 gacaacgtga aggtgtcgct ggccttcggg ctgagcatcg ccacgctggc gcagagtgtg 2221 ggccacatca gcggcgccca cctcaacccg gctgtcacac tggggctgct gctcagctgc 2281 cagatcagca tcttccgtgc cctcatgtac atcatcgccc agtgcgtggg ggccatcgtc 2341 gccaccgcca tcctctcagg catcacctcc tccctgactg ggaactcgct tggccgcaat 2401 gacgtgagtg gggtgtccct gggcttgggg gggttctaga atgatgctga aaggcactgg 2461 ttccatcctc tgcccattgt gcagatgggg acactgagga acggagagga caagaggttg 2521 ctggaggtca cgtagagagc tggggggaag agctggggct ggaactcagc tatgcatgcc 2581 tcccaaagcc tgttttctgc caggcactgt gggaagctga gatccagaga ataatggtct 2641 tgccaatgtc ccctgcaggg catctattat ggggaataag cttggccagc agttcctcgc 2701 cccttggctg tagctttttg gcccttctca gtcctgcctg tgccgccagc tccctcctcc 2761 tgcagccctg caccctgggg aaactttgcc cgctgtcccc agccaccctg aaccaaatgc 2821 ccagcctgtc tgcagctggc tctgcaagtg tgtgagcagg actccctcag ggagcccccc 2881 atattcacac tagtttccaa ataaaccacc tctaggaatc aagagaaagg ccctcttcca 2941 ctcttttgcc cctgagatta gacaaagata agggagtgaa aacactctct ggggctgttt 3001 gaaggcagtt ttcctggatt acagtatggg ctggggggca agcgctgggc tccatggtct 3061 ctaggcactg agaggtgtgg cgtgtgtgtg catgtgcgtg tgcgtgtgtg tgtgtgaagg 3121 tgtgtatgtg tgcatgtgtt tgccagcatg agtctctgtg cttgtgtcaa ctgtgtgcat 3181 gtttgtgctg ctgtgtaagg gtgtgtgggg gtgagtttgc aacacgtgcc catggctcct 3241 ggcttgaatg gggtctggac tggggtcact aatgacaagc agatgctggt gactgggtgg 3301 cagctgtgga aaagaatgtc tcctgggctg cttagcatgg caaattggcc ctggtggcag 3361 ctgcctgctg tcccagacac ggcctttccc agctcctcag acaagtgcaa actcaggccg 3421 ggcttgggcc acagcagggg aggatttggc ctgagagact ggggaaggct tggaggatgt 3481 ctctgagggc ccaagggaca ggtgagcagg cctgggggtg cccttacagg gagggagaga 3541 agctaaggag cagagaggag gactcgtcta gagagatgag gctggcgggg ctgtgggcag 3601 ggcatgtggg tgtggggacg gtgtgggcca tctctgaggg cgcctcagag atggcagata 3661 gtgattacag cagctgtcct ctcgcttccc agccaaagtt cagatcctgc ggctggcagc 3721 ccaggagagg ctaggtgaag gtctggtgca gagggcagct ggctcagcct ggccatgggg 3781 ggcttagcac ttctgtgtca cggtgacacc tcacccaacc tcctctgcag ccaacctctg 3841 ctaggcccaa gattgaagat tagctccgtg ggctggagtt tagactttag ccagtttaga 3901 cgtggccgcg ggggatgtac gggacagagc tcaggcaggc cacatcaagc tctgcccccc 3961 caggcctcag ttgccagtgg gtgcagagct tgtggcctca gggagttctg ctgggtaggg 4021 tcaagctcac actgaagctt ggctgggtat gatgggctgg gggagcgtcc ctgtagggga 4081 gtggatgtga tttccaggct ttctggcccc gtctcttccc tcccatctca cagggcggag 4141 cctctgcacc tgctggcgaa ggcttcaccc tctagtatgc gcatccgagg cagaggcggg 4201 agggtgggcc ccttctgtgc catctggaac agaggccaca ccagcctccc gtgccccatt 4261 ccctccctgg ccttcatttt ttatagtcac cccaatactt gggctgggcg tgttgcaaat 4321 gggagagaaa gaggagcagc ctagtgtggg gtccggccct gggctgagag gcagacacct 4381 gggttcaaga cgtgtccact gctaacttgt tgagcttctt tggagctgcg gaccctgacc 4441 ctcgagaggg aactcaggtc ttgtgacctc acagccacac ccagacagcc agctcacttc 4501 attgctttga gcttatcacc catcccacga aagctggcta agagcagccc agcaggggca 4561 gtgctgaaca taagggcgct tagcatgatg gtgggggctc aggcgctgtc ctgtcccaac 4621 agtggaaggg tggggttcag gacctcaact ctgggcctag aaatagagaa ggtacccctc 4681 taagggctcc cgtcagacac tggccctgga actggagggg cctcaggggt ggcctggatg 4741 cctcaagagg agcagggaac agtctgggca gcaggtgaca cactctcttt catgacctgg 4801 ggtaggctcc tgcagcctct ctggccctga gccccagccc agtcaaaacc tgggtggggc 4861 aagtggttgg catggagatt tccaaggaaa acagagaaag atgtggcagg aagtggttgg 4921 ggtgagtcag ggggtgtccc ttcgggacat gctggggaca actttctcct gactgactca 4981 gggctcagga tatgccctag agagaccgtg ggcctccgtc cagcctgcaa ggtcccggct 5041 agttctaaga gccaaatacc aattttggct aagggtgaga ggctctgagg ctggggtgga 5101 cactctcacc tgtccctgtc ctagctcagc cactaacacc atgtggcatc acacaacaga 5161 ctggcctgtg tggccctagt tcctgtctat gagataggga catagcaggg tgtggctggg 5221 ctctgagaag taggagatgc tggtggactc aggattcctg gcatttgctg gcttttttca 5281 ttcttctgct gtctggtctg ctcagccggc tccctgcaag catgaccagg gactgctggg 5341 tgctcaatgc agggctgggt tagcccggct ccctcccgag agaagcccac agccctaggt 5401 caagataagc cagtgcccag ctgcctgtga tatgaagcag gaggcagatg cgataagagg 5461 tgtcagggcg ggcccgggaa cttttgaact taaggggtgg gagggccagg aaggcatcag 5521 ggaggaggtt tcgtaggagc ctgaatgtgg agacactgca gagggaaggg gcagagggac 5581 tgtgtgagca agcacaggct aggaggaggt gagggccgtg gtgcgggagt tgttgggtat 5641 ggtcaggctg ggggtgcatg ggaggagggt ggtgagggct caggattcgg gccaggggct 5701 gcatccgggg gaaggggtct ggattcccag agcctgtgat ttcagcccgc tgggctcagg 5761 cagagggcaa agctaccctc ttcggggtct tctcccagcc ctgctaattc cgggcctgac 5821 tgctcaagaa gtgtttctac ctgcagcatc aggggcctga ctgaagccct aagttctccc 5881 ctttatcccg tttttctggg cttcagtttc cccagtcata gagtgagagg cctcttcatg 5941 ccaccagttc tcccgggggt gctgctgcct cctccagagc tcaggggagg gatggggaaa 6001 ggaaggcaga gtttccatgt ccctgcccag cccgtcctgc ccagggaggg gctgggggct 6061 gggtggtgat gccacatctg ggacatataa ttactgtttc cgccagcccc agatgagggg 6121 gagggcacag agatggggag ctttgtggtg gagacttccc tcaccatgga aaatcctgac 6181 gctgcttccc ctttagggac ctcagaacag cccagccggt cccagtgttg cccaccctga 6241 tgcttggccc tgactgggat ttgccctggg aactctgaag gggccatgct ttgagagggg 6301 acacggcctc ctgggatacc tgtctgaggg gctcaccccc tgctcaccac tcccaggcca 6361 cagcctcctg tcacaccttg ccttcccttc tccaccccag gcaaccttct agcagcatga 6421 agtggccatt agctcactgc aagccaattc cagatggtac ccccacttag tctagggccc 6481 ccacccagca ggggccatgg cccttacctt ctggaagcac caatgagtct ggagtctcct 6541 gagtggctgg gatctgagcc ctcacaccgg gaggtgaagg caggaaaatg ctgtccgcga 6601 ggccctgcaa gtggccagga tcccctcagt cagggcttcc ccatggggat gagaggggct 6661 ccttgcccac atggagtggt gcccaggggg atcatgaggg gctgtcttca ctcagccagg 6721 agctacagtt ctgtggggtg ggcagactct gaggctgaaa tctccaactt aaaagatatc 6781 cggaaaggcc ggaaaatgcc cccggccctt ccagcagctc ctttcagtgc ctgcaatctc 6841 gctgtcaggg ccccttgaaa ggcagatttc tactcagtgt aaagaaggtt gttgttgata 6901 ttgttgttga cacgaagaag gggctgtctc taagtcaata agctccctgc cattaggggt 6961 gtgcaagtag atgctttctg gtgaggaggc tgctttgggg gtgctagtct atgcgggggt 7021 ccagtggggt gggtgacagg ttctgcagca taggctttgt gtcatgctga gatcagcaat 7081 tctgatggcc tgcgggggat cctgtgctta ggtttctgga tctggggctg gagagtgacc 7141 accccgatgt gaggcaggag gcacttttgg agactgcggg ggctcgaatc tgggccaagg 7201 cctccatttt actgatgggg aaactgaagc ccacagaggc gtggagactt gtcaaggtgg 7261 cactgcctcc tagcccttga ttattcctgc tgctccaaag tgtacacaca tggcacaaac 7321 acaaacatgc acacacatgt gctcttacgt ggaggacaca cacacatggt acacaaagca 7381 cattctcaag actgggtggt cccactcaga ctctgggacc caaggagggt tgggcgggga 7441 ttcctcaatg gagccttttc ctctccctgc cctggagtta ggaaaagaag gagggaggga 7501 gggaggaagc cattgctttg tgtattgttt cttgtcagga agatgaaatg gcttctggga 7561 gcaaataaag gccttgttga gacctgctgc tttctcacat ggggggctca tttttttctc 7621 ttctcttccc tctctagctg gtagtggcag ctatgtgggt gtgtgacaca gggagacagt 7681 gaggcaccca gaagtgccat cagacatacc agtgcaaaca cacagcacag cctccaggac 7741 ctcatgtcct gcagggatgc ctgtatgata tagctgttcc cagggaggcc gaggcacttg 7801 gtcagtacct catcagttga tgaaaaagag tgtgcattct ctaattcagg ggtacagggt 7861 tttcatattt ttctgaagtc aagcttgtta attatggggt tcaaaccctc cctgatcatg 7921 ttattggtag ttttcggctg cttcatttat tctgtacatt tctaatagaa gattgttaac 7981 atttttcact ctggtggtag ggtgatccag tcctccttgt aattttgtca attttcccct 8041 catttatttt taggctatgt tgtttggtgc atacaagtgg gggatttttg cagttccttt 8101 atagattttt attttttttt ttgagacgga gtctcactct gtcgcccagg ctggagtgca 8161 gtggcaccat ctcggctcac tgcaagttct gcctcccggg tttatgccat tctcccacct 8221 cagcctcccg agtagctggg accacaggcc accacacccg gctaattttg tttttgtatt 8281 tttagtagag acggggttta accgtgttag ccaggatggt ctcgatctcc tgaccttgtg 8341 atccacccgc cttggcttct cagagtgctg ggattacagg cgtgagccac cgcgcctggc 8401 cagttctttt atagattttt aaaatgtaat tattgtgtaa taaaccactt acaatctaac 8461 aaaaaagaga aagagggagt cagccctgga cacatgtggt catcacagac acagcagaca 8521 cttatctaca aagacacaca gaggcacaca aaaccaggaa tccccccatg tccacgtgtg 8581 aacacccatg gaggagtgac actctggagc ccacataggt cccctcactg cccagtgctg 8641 agtcttggag gcactggggt gggcagggca ggcctcgatg tctcctatcc cttgagaacg 8701 aaagctcaga gcctcagtca ggcctggctc tggagcctgc tcttccccaa ggccagggca 8761 ccagggtgcc caggccaagt caggggcccc atgccttgga agccaccctg gttggcctgt 8821 ctatgggtag cagggagtgc ttagagcaca ttgcctggag agatcatccc tgggctgccc 8881 tagagccagg acacactggc agccacagaa ccaccttctg ccagctccca agtccaagct 8941 gggaatagcc aggtcccttg actgggccta ggagtggcca gcccattgac ctgtgagtgt 9001 agggtggcac agactatggg gcaaggatcc tggctttgct gcatcctccc tgggcctcag 9061 cctctgcgtc atcatctcac tgagccatcg cacaggctgc cctctagggc tcccagaggc 9121 taatgattgg cccattgttt cccagctaga aagtgaagaa gaccgccctg ggtccggaga 9181 gcatctctgg agccaggctg cccctagcaa gggtgggagt tctagaaaat tagcattctc 9241 tgccacttct atcagcacac agtaagcctc ccctcagagg cgtgggcaga gaaatggcag 9301 aggtccccca ctctgtcttc accgagctcc caggccagga ggagatgcac ccacataggc 9361 cgcaggaaga ttgatttcct acaagatgca cagagaattc agtgagggca tggtgggtgg 9421 gagcagaagt taattccagc cagggatctg ggaaggcttc taggagctgg tggggtctga 9481 actgggcctt gagtagcggg cttacaaggg cttagcacaa aatggagagc ttgtatcttt 9541 ctgacacttc agaagaaatg tgtggattat tctttcggta atacttgcat tcacaaaacc 9601 cagggctgca gacaaaagcg ggaagacaat tgagaattga gaattgagaa ttgttctgat 9661 tcttactttt tttttttttt ttttgcctta ataagacctg ggccaggcaa aactacctgg 9721 ggatgtgcaa atatatatgt acatatatat aaaacaagtg actacaatgg gaactgtcct 9781 tgtttaagca agttttcaaa tttaatgggt tgtaaacagt aacgtacatt tgaagtattt 9841 tacctgctct ttcctggaca ttgagtttca acaggccttt gagtgcccct tccaattctg 9901 aattatcaag tgtttccaga tgtaaataat gcaagtgtat tagatagttg aaggaaggtt 9961 gtcagtagat gttgaagcta tcaggggagg cttcctggtg gtagtggtag tgggtattgg 10021 agaggaaggc tgtcagccca tgtggttctc agcagtcacg aaggcacatt ccagaattcc 10081 cagggcaggt ggctgacccc tccccttccc aaggactcag agtacagggc ctggaactat 10141 caccctctgc tctgcccact ttgcatgaaa agcatgttgt ctttgggtag gggctggggc 10201 tctcgcacct ggttaagaac cagaggagat gagctctttc tggtcacatc tgtgagggat 10261 ggggctggga gggttctcca aggcgggagc cacttacagc gatgactcca ttaatcatcg 10321 gggaagggct ggtttcagga cttctgccag ctagcaatta ggccaaccct ggagagcaga 10381 agagagagga atagaaggag ccacgagctt cctgagggct cagatacaga gggacagggg 10441 cctcacaggt gcaagtgtgg gtgggcatca ggactagccg ggctggcctc accagcctca 10501 accccattca gcctgtccta actctgggca ggcttctgcc agcagctcca cccgccgtca 10561 ctccttctgc ctgtccccag atcctgcaca cacaatgaga agaaccaaaa caagagtcac 10621 taccactgcc ccatccctcc tgcgtcgaca actctttcca aaagccctga gacggcccct 10681 ttggcctttg aacctcccag ctgctctgga gagcaggcac ggacaatgag atccattttg 10741 cagatgggaa gactgaagac cagagggaat aggccatgct catggtgcca gaaagtagaa 10801 gagtcagaac ctgaacacag ggcttctgcc tctttggccc aaccttggga cagaaaggga 10861 actgggcatt ggccagaggg ctggcggacc taagggatgt agccctgggg tccgccagga 10921 aaggcccaaa gctggggctg caaggcaggg gaggggatgt gagtcattcc ctgtaaccca 10981 gggctgcaga caaaggcggg aagagaattg ttcttgtagg atggcctcag ggtggggctg 11041 ggaaaacctc caaggtgtgc ccccctacct tggattttgc aaaattctct atggccttgg 11101 agacactccc atatcctgag gatgggagct gggtagtttg tctcccagct gggaagtgtt 11161 tgggtgcacc agccctgcct gggagaaggc agcctaagtg gcctcaagtg ggcatctttg 11221 caagtgagcc tttgctgatg tggtccatct cccctgtgtg agtgcactta gcccctggga 11281 cggccacaaa gcatagtgga aggtgctggg gcttcctggg gaggggtcct ccgggggcag 11341 ctgcatgggg agggccttca tgacctcaca gcagcttcca ttcccttctc tttccatgag 11401 tcatgtttct aaaagtggcc caggagtaag tggcagccag acggtggtgg cggggcctat 11461 ctggccaggc agagggaggg tgaggctgag gccagcagtg gggaggaaga agagagaagg 11521 agagacaggg agggcagggc cagaagcaat gggagacagg ccttggacca aggaaagaga 11581 cggggtggag aaggagagag agagggtgga gacaataggg aggcaggcac agaggagaaa 11641 gaggggtgga gggagccagg acctcaccga aggcctcctc agccctggaa tttagatgca 11701 gtcgggcatg gggtggaatg ttctggactt ttgggtatga agccgtgtcc cctgctgggc 11761 cttcccacct ttttgcatct cttctcctag gagtgctcct gaccatcacc ttcatgcctg 11821 gggctcgccc cttgcctctg gtcttggtac cccagaatac cctggcctgg atgcagctgg 11881 atgcaaaggc cccagctcac cccaggcctc tccagcttct aggcagagtg gggcctgggt 11941 ctaggcaggt attaggggct gggctggagt ttcattaaca cagggggtgg gttcaaggcc 12001 tgatttccac tacctgccgt gtaggcttgc ctgggaccct gtgatgggct ctgaaggccc 12061 atctgagggt ccgcccttca tgcctgggcc tgggaggcct gggtatcctt ggggtcctgg 12121 gacacagtcc ctgcctaccc tcctcaccag tcctcaccac ctctctcccc tgcagctggc 12181 tgatggtgtg aactcgggcc agggcctggg catcgagatc atcgggaccc tccagctggt 12241 gctatgcgtg ctggctacta ccgaccggag gcgccgtgac cttggtggct cagcccccct 12301 tgccatcggc ctctctgtag cccttggaca cctcctggct gtgagtcagg ggccctccca 12361 gatggaggtg ggggaaggga gggcgggggc tggtggggtg ccctgccatg ggcagccagt 12421 gggactcccg acagggctct tgccattggg tggaggatgg cgggtcagcg ctgggggctg 12481 ggggcagggt cctgccctgg agaggagcac agggacctcc tgcccagctt ggggtcagca 12541 ctcctctttc cctgggtctc attgtccccc accctgattg ttctctttct ccctccaacc 12601 tctccctcct ctcactctct cttcacctat gactctctgc cttcgcccct ccctctgttt 12661 ctttccctca cagattgact acactggctg tgggattaac cctgctcggt cctttggctc 12721 cgcggtgatc acacacaact tcagcaacca ctgggtagga gacccacggg gggtggggtg 12781 ggaagctttg gtgtcccatg gtaagcctga ccccaccctc acagtgtccc ttcctgttct 12841 ggaggctctg ggagacagcc agaggacagg aaatcaggaa actgaggcct gccatgtaga 12901 ggcaggctgg gggtcacact gccagcactt tcaggcctag tctctgccct cccagctcgg 12961 ccctgcccca tgctgcctgg cctccaggtc ttcccagctg cgtggttaaa agtggggctc 13021 caaatcctgg ctcagccact ttcgggttta gcatgacctt gcgcagtgtg cttgagcttt 13081 ggtttcctga gctgcggagg gggatatggt ggtgcccacc tctcagggtg gccgagaaga 13141 ggaaagggct cactccccat ctgtaaactg agctcaacac agaggaggcg ctcagtggat 13201 tttagctctt atggttgtgg atgtggatgt gctaggccag ctttgcatta gacaatggtc 13261 tctggggccc ttccaaagct gggagtgtgg gggcagtggc cttcctcaag aaggggctgc 13321 tactgcccat gcctgagctg ggccccacag aggcaaggag ttgaccctac cacgtactct 13381 ggcctgggcc ggttctgagg ggcaccggaa tcatgatgtt aggatttggc tctcctacct 13441 gcctccatcc caggtgggaa aaacctgtcc aacggggtgg tgggctgtgg ggtaacctag 13501 ggaacgcttc ccaggggctt ttgagtggag ccctctgaac acacctgctc tgttcctaga 13561 ttttctgggt ggggccattc atcgggggag ccctggctgt actcatctac gacttcatcc 13621 tggccccacg cagcagtgac ctcacagacc gcgtgaaggt gtggaccagc ggccaggtgg 13681 aggagtatga cctggatgcc gacgacatca actccagggt ggagatgaag cccaaataga 13741 aggggtctgg cccgggcatc cacgtagggg gcaggggcag gggcgggcgg agggagggga 13801 ggggaggggt gaaatccata ctgtagacac tctgacaagc tggccaaagt cacttcccca 13861 agatctgcca gacctgcatg gtcaagcctc ttatgggggt gtttctatct ctttctttct 13921 ctttctgttt cctggcctca gagcttcctg gggaccaaga tttaccaatt cacccactcc 13981 cttgaagttg tggaggaggt gaaagaaagg gacccacctg ctagtcgccc ctcagagcat 14041 gatgggaggt gtgccagaaa gtcccccctc gccccaaagt tgctcaccga ctcacctgcg 14101 caagtgcctg ggattctacc gtaattgctt tgtgcctttg ggcacggccc tccttctttt 14161 cctaacatgc accttgctcc caatggtgct tggaggggga agagatccca ggaggtgcag 14221 tggagggggc aagctttgct ccttcagttc tgcttgctcc caagcccctg acccgctcgg 14281 acttactgcc tgaccttgga atcgtcccta tatcagggcc tcagtgacct ccttctgcaa 14341 agtggcaggg accggcagag ctctacaggc ctgcagcccc taagtgcaaa cacagcatgg 14401 gtccagaaga cgtggtctag accagggctg ctctttccac ttgccctgtg ttctttcccc 14461 aggggcatga ctgtcgccac acgcctctgt gtacatgtgt gcagagcaga caggctacaa 14521 agcagagatc gacagacagc caggtagttg gaactttctg ttccctatgg agaggcttcc 14581 ctacacaggg cctgctattg cagaatgaag ccatttagag ggtgaaggag aaatacccat 14641 gttacttctc tgagttttag ttggtctttc catctatcac tgcattatct tgctcattct 14701 tcagttctct actccctctt gtcagtgtag acacaggtca ccattatgct ggtgtatgtt 14761 tatcaaagag cacttgagct gtctgaagcc caaagcctga ggacagaaag accctgatgc 14821 aggtcagccc atggaggcag atgcccttgc tgggcctggg ggttttccaa gccctcagct 14881 ggtcctgacc aggatggagc aagctcttcc cttgctcatg agctcctgat cagaggcatt 14941 tgagcagctg aataacctgc acaggcttgc tgtatgaccc ctggccacag ccttccctct 15001 gcattgacct ggaggggaga ggtcagcctt gacctaatga ggtagctata gttgcagccc 15061 aaggacagtt cagagatcag gatcagcttt gaaggctgga ttctatctac ataagtcctt 15121 tcaattccac cagggccaga gcagctccac cactgtgcac ttagccatga tggcaacaga 15181 aaccaagaga cacaattacg caggtattta gaagcagagg gacaaccaga aggcccttaa 15241 ctatcaccag tgcatcacat ctgcacactc tcttctccat tccctagcag gaacttctag 15301 ctcatttaac agataaagaa actgaggccc acggtttcag ctagacaatg atttggccag 15361 gcctagtaac caaggccctg tctctggcta ctccctggac cacgaggctg attcctctca 15421 tttccagctt ctcagtttct gcctgggcaa tggccagggg ccaggagtgg ggagagttgt 15481 gatggagggg agaggggtca cacccacccc ctgcctggtt ctaggctgct gcacaccaag 15541 gccctgcatc tgtctgctct gcatatatgt ctctttggag ttggaatttc attatatgtt 15601 aagaaaataa aggaaaatga cttgtaaggt ccttcaggct tcctgtagtt tttcttcttt 15661 tgatgctgtg tccccacaaa tgtttctgga ttactccaca aggaaatcag gccactgcta 15721 gagacccagt ctgaggagga gccactgcct ccccttctgc cttcaagacc cctgatctca 15781 ggcaatggat acagccacac cacagaaccc catctgaggg acacagggtc ctgcccctag 15841 taggagactt ccagagccca gtgggatgac tttggagacc tgggggcagg gaaaaggggc 15901 aggcttctga tcagtttaaa tggaccgatg ggagccattt ctgattccgg agtatggaag 15961 ggatggggga aagcagggct gaagtctaac agccccctca tcccctctac cctccacaga 16021 gcagggccca gggaacacta gggattgctc caccttcctc cctccctcca ctcacatttg 16081 caacccatct gacctgggct gggcgtctca tgggagacag actcactcat cagagcccag 16141 tgcagttagg gctacttcag gctgagactg ggaccctggc tcctgaccct cccgacgtgc 16201 acacacactt agtagtgcct gataataggg aacaggtatc accacggcag tgggctgagg 16261 caggaaatag tgtatggaca ggtcctgggg ccccagcact gctcctggga gacacatggt 16321 tcctgtcccc tctgtggaat gcctggctga tggtgatata aggggggctg ggtctcaggg 16381 agccaggggc taggcatccg caatgaagac tgaggccatg ttgatggaac agggtttcta 16441 atttaagtgt gccctgggtc actaggctgt ctaagtccct gcaaatcagt gcatcacatc 16501 tgcacactct tttccgttcc cttgcaagaa cttctagccc atttaataga taaggaagct 16561 tatctcccag cttaagaggg gcatataaat ggcagagtgc cagccaagct atgggaattg 16621 ggtatgggcc agcccgctgc atcccaggcc tgcctgtgag ggtgtgccga ggctatctct 16681 cacagccctt ctcagcttgt ctccttaatt tgtcccattc ttcttggcct gaagccctcc 16741 caatcaccac tatgggccca gccacgccac ctcaactcct actcattcac ttctaccccc 16801 acccccattt cacccccgct ccatggcaca gccttcttta gtgtattgct tagatatgac 16861 ttttagaatc ctagagccac gaggcagggc ctgaataagc cattagggaa ctggtatttc 16921 ttgagcactt accatgtgtg aagaatctct ctgagatttt gcatacattc gctctaatct 16981 ttacaacatc cttagaaggt agagatacgt gtccccattt gtagaagacg ccagggcccc 17041 tgaagatgaa atgatttgcc gtaggccaca cagcaggttg gtggcagaat tgggatttga 17101 acctattctg cttggcttca aagatcaggc tctttgcacg atgtggtctg ggccggtttt 17161 gtcatgattc ctgctaagtt aagctctggg ctagccagga agccggactg catgaagaag 17221 gcagccactc ctgcagagtg ggcatgggga gggggaaggg aggagaaggg ccagccacag 17281 agccatctgg catctggaga agcctgttca ttccatggca tctggagaag cctgttcatt 17341 ccagggctaa ctggacgtgg tgtcacccaa acctccctgc tgccttccac ggcctgactc 17401 tccccctcct tgggaggaaa gtgtctgagg accatgttca cccagcagaa tacctgagaa 17461 ggggaagggc aatgctgcac catgagggat aataatgcac taagacaggc cctcagctac 17521 ccatcaggcc agggggcaac agctttgggc taaagggatc ctagactcct cctcaccttc 17581 cagcctgtgg gtttagtgct ccaggcaccc catctctttg gggctacccc tgactctgat 17641 cttctcatc //